全文获取类型
收费全文 | 28534篇 |
免费 | 1697篇 |
国内免费 | 134篇 |
专业分类
耳鼻咽喉 | 336篇 |
儿科学 | 588篇 |
妇产科学 | 618篇 |
基础医学 | 3822篇 |
口腔科学 | 1604篇 |
临床医学 | 2120篇 |
内科学 | 6965篇 |
皮肤病学 | 711篇 |
神经病学 | 2345篇 |
特种医学 | 698篇 |
外科学 | 4062篇 |
综合类 | 147篇 |
现状与发展 | 1篇 |
一般理论 | 7篇 |
预防医学 | 2329篇 |
眼科学 | 663篇 |
药学 | 1630篇 |
中国医学 | 149篇 |
肿瘤学 | 1570篇 |
出版年
2023年 | 223篇 |
2022年 | 189篇 |
2021年 | 1011篇 |
2020年 | 561篇 |
2019年 | 995篇 |
2018年 | 1162篇 |
2017年 | 682篇 |
2016年 | 740篇 |
2015年 | 880篇 |
2014年 | 1170篇 |
2013年 | 1530篇 |
2012年 | 2477篇 |
2011年 | 2382篇 |
2010年 | 1319篇 |
2009年 | 1194篇 |
2008年 | 1898篇 |
2007年 | 1918篇 |
2006年 | 1740篇 |
2005年 | 1649篇 |
2004年 | 1442篇 |
2003年 | 1265篇 |
2002年 | 1151篇 |
2001年 | 263篇 |
2000年 | 188篇 |
1999年 | 236篇 |
1998年 | 158篇 |
1997年 | 134篇 |
1996年 | 105篇 |
1995年 | 139篇 |
1994年 | 110篇 |
1993年 | 94篇 |
1992年 | 103篇 |
1991年 | 104篇 |
1990年 | 83篇 |
1989年 | 78篇 |
1988年 | 82篇 |
1987年 | 84篇 |
1986年 | 75篇 |
1985年 | 74篇 |
1984年 | 55篇 |
1983年 | 45篇 |
1982年 | 35篇 |
1981年 | 46篇 |
1980年 | 38篇 |
1979年 | 39篇 |
1978年 | 42篇 |
1976年 | 39篇 |
1975年 | 30篇 |
1974年 | 35篇 |
1969年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Antonio Montalvo Afonso Fernando Ruiz Juretschke Rosario González Rodrigálvarez Olga Mateo Sierra Begoña Iza Vallejo Roberto García Leal Marc Valera Melé Vicente Casitas Hernando Jose Manuel Hernández Poveda Carlos Fernández Carballal 《Neurocirugía (Asturias, Spain)》2021,32(1):1-9
Background and objectivesThe treatment of deafferentation pain by spinal DREZotomy is a proven therapeutic option in the literature. In recent years, use of DREZotomy has been relegated to second place due to the emergence of neuromodulation therapies. The objectives of this study are to demonstrate that DREZotomy continues to be an effective and safe treatment and to analyse predictive factors for success.Patients and methodsA retrospective study was conducted of all patients treated in our department with spinal DREZotomy from 1998 to 2018. Bulbar DREZotomy procedures were excluded. A visual analogue scale (VAS) and the reduction of routine medication were used as outcome variables. Demographic, clinical and operative variables were analysed as predictive factors for success.ResultsA total of 27 patients (51.9% female) with a mean age of 53.7 years underwent DREZotomy. The main cause of pain was brachial plexus injury (BPI) (55.6%) followed by neoplasms (18.5%). The mean time of pain evolution was 8.4 years with a mean intensity of 8.7 according to the VAS, even though 63% of the patients had previously received neurostimulation therapy. Favourable outcome (≥ 50% pain reduction in the VAS) was observed in 77.8% of patients during the postoperative period and remained in 59.3% of patients after 22 months average follow-up (mean reduction of 4.9 points). This allowed for a reduction in routine analgesic treatment in 70.4% of them. DREZotomy in BPI-related pain presented a significantly higher success rate (93%) than the other pathologies (41.7%) (p = .001). No association was observed between outcome and age, gender, DREZ technique, duration of pain or previous neurostimulation therapies. There were six neurological complications, four post-operative transient neurological deficits and two permanent deficits.ConclusionDorsal root entry zone surgery is effective and safe for treating patients with deafferentation pain, especially after brachial plexus injury. It can be considered an alternative treatment after failed neurostimulation techniques for pain control. However, its indication should be considered as the first therapeutic option after medical therapy failure due to its good long-term results. 相似文献
3.
Ana Paula Valverde erson Camargo Ana L cia S Rodrigues 《World Journal of Psychiatry》2021,11(11):981-996
Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have all been shown to play crucial roles in the patho physiology of MDD. Although conventional antidepressants are widely used in the clinic, they can take weeks to months to produce therapeutic effects. The discovery that ketamine promotes fast and sustaining antidepressant responses is one of the most important breakthroughs in the pharmacotherapy of MDD. However, the adverse psychomimetic/dissociative and neurotoxic effects of ketamine discourage its chronic use. Therefore, agmatine, an endogenous glutamatergic modulator, has been postulated to elicit fast behavioral and synaptogenic effects by stimulating the mechanistic target of rapamycin complex 1 signaling pathway, similar to ketamine. However, recent evidence has demonstrated that the modulation of the NLR family pyrin domain containing 3 inflammasome and gut microbiota, which have been shown to play a crucial role in the pathophysiology of MDD, may also participate in the antidepressant-like effects of both ketamine and agmatine. This review seeks to provide evidence about the mechanisms that may underlie the fast antidepressant-like responses of agmatine in preclinical studies. Considering the anti-inflammatory properties of agmatine, it may also be further investigated as a useful compound for the management of MDD associated with a pro-inflammatory state. Moreover, the fast antidepressant-like response of agmatine noted in animal models should be investigated in clinical studies. 相似文献
4.
5.
Soraia Azevedo Francisca Guimarães Joana Ramos Rodrigues Ricardo Branco Elisa Rodrigues Filipa Teixeira 《Reumatología clinica》2021,17(7):422-424
IntroductionNerve compression by anomalous masses located at the wrist and distal forearm is an infrequent condition. They may compress underlying structures in the carpal tunnel region, causing pain and paresthesias, which leads to the wrong diagnosis of carpal tunnel syndrome.Clinical casesWe present three cases of patients with symptomatology and clinical tests compatible with compression of the median nerve in the carpal tunnel but whose physical examination showed a soft mass in the distal region of the forearm which was compressing the median nerve, as demonstrated by ultrasound evaluation.DiscussionThe reported cases of accessory muscles or lipomas described in the literature as causes of median nerve compression clinic are mainly described only after the surgical decompression of the carpal tunnel, due to the maintenance of residual symptoms.ConclusionCareful examination with an ultrasound evaluation prior to surgery may help to identify these cases and help planning surgical treatment. 相似文献
6.
7.
8.
Dambach Micha Fieber Jakob Wanzenried Manuel Fehr Tobias Konrad Christoph Goertz Roland Fieber David 《Der Anaesthesist》2022,71(11):846-851
Die Anaesthesiologie - Die Anwendung von hohen Sauerstoffkonzentration birgt Gefahren für Patienten und Anwender. Hohe Umgebungskonzentrationen an Sauerstoff bergen die Gefahr von... 相似文献
9.
Sibylle M. Winter Katja Dittrich Peggy Dörr Judith Overfeld Imke Moebus Elena Murray Gergana Karaboycheva Christian Zimmermann Andrea Knop Manuel Voelkle Sonja Entringer Claudia Buss John-Dylan Haynes Elisabeth B. Binder Christine Heim 《Journal of child psychology and psychiatry, and allied disciplines》2022,63(9):1027-1045
10.
Caio Henrique de Carvalho Assuno Júlio Csar Trabanco Raquel Fornaziero Gomes Renata Rodrigues Moreira Alessandra Giannella Samelli 《La Medicina del lavoro》2019,110(4):304
Objective:The present study evaluates a training program for fitting different hearing protection devices (HPDs) based on personal attenuation rating (PAR) before, immediately after, and six months after training.Methods:A total of 67 workers from a public university in the city of São Paulo, Brazil, were invited to participate in the measurement of PARs for foam and silicone protectors through the 3M™ E-A-Rfit Validation System. Two evaluations were performed for each protector at each sampling date: one after reading printed material (the package instructions) and another after being trained by an audiologist. The same procedures were repeated after six months. The final sample consisted of 30 individuals. ANOVA was used for statistical analysis.Results:Larger PAR values were observed after training by the audiologist, and smaller values were observed after six months. Then, after re-training, the values increased again. There were no statistically significant differences in PAR among the HPDs tested. Even after the two training sessions, 23 to 27% of the subjects did not obtain adequate PAR values.Conclusion:These findings emphasize the need for continual worker training in the correct fit of earplug HPDs and the importance of longitudinal PAR monitoring. In addition, some workers, despite the training provided, did not adapt to the HPDs used. Therefore, it is essential that other protection methods and/or other HPD types are made available to these individuals.Key words: Hearing, noise-induced hearing loss, occupational health, personal protective equipment, hearing protection devices 相似文献