全文获取类型
收费全文 | 7130篇 |
免费 | 440篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 314篇 |
儿科学 | 101篇 |
妇产科学 | 85篇 |
基础医学 | 1089篇 |
口腔科学 | 143篇 |
临床医学 | 429篇 |
内科学 | 1572篇 |
皮肤病学 | 111篇 |
神经病学 | 654篇 |
特种医学 | 230篇 |
外科学 | 898篇 |
综合类 | 58篇 |
预防医学 | 261篇 |
眼科学 | 125篇 |
药学 | 700篇 |
中国医学 | 25篇 |
肿瘤学 | 823篇 |
出版年
2023年 | 39篇 |
2022年 | 37篇 |
2021年 | 145篇 |
2020年 | 95篇 |
2019年 | 113篇 |
2018年 | 128篇 |
2017年 | 116篇 |
2016年 | 144篇 |
2015年 | 138篇 |
2014年 | 200篇 |
2013年 | 218篇 |
2012年 | 364篇 |
2011年 | 441篇 |
2010年 | 224篇 |
2009年 | 200篇 |
2008年 | 341篇 |
2007年 | 378篇 |
2006年 | 330篇 |
2005年 | 374篇 |
2004年 | 381篇 |
2003年 | 315篇 |
2002年 | 291篇 |
2001年 | 245篇 |
2000年 | 247篇 |
1999年 | 218篇 |
1998年 | 74篇 |
1997年 | 71篇 |
1996年 | 74篇 |
1995年 | 59篇 |
1994年 | 67篇 |
1993年 | 60篇 |
1992年 | 158篇 |
1991年 | 149篇 |
1990年 | 140篇 |
1989年 | 128篇 |
1988年 | 123篇 |
1987年 | 116篇 |
1986年 | 113篇 |
1985年 | 97篇 |
1984年 | 70篇 |
1983年 | 54篇 |
1982年 | 34篇 |
1981年 | 24篇 |
1980年 | 23篇 |
1979年 | 39篇 |
1978年 | 27篇 |
1977年 | 29篇 |
1974年 | 23篇 |
1973年 | 18篇 |
1971年 | 20篇 |
排序方式: 共有7618条查询结果,搜索用时 15 毫秒
1.
2.
Eriko Yanagida Hiroaki Miyoshi Mai Takeuchi Noriaki Yoshida Kazutaka Nakashima Kyohei Yamada Takeshi Umeno Yasumasa Shimasaki Takuya Furuta Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):680-688
The interaction of CD47 and signal-regulatory protein alpha (SIRPα) induces “don't eat me signal”, leading suppression of phagocytosis. This signal can affect the clinical course of malignant disease. Although CD47 and SIRPα expression are associated with clinicopathological features in several neoplasms, the investigation for adult T-cell leukemia/lymphoma (ATLL) has not been well-documented. This study aimed to declare the association between CD47 and SIRPα expression and clinicopathological features in ATLL. We performed immunostaining on 73 biopsy samples and found that CD47 is primarily expressed in tumor cells, while SIRPα is expressed in non-neoplastic stromal cells. CD47 positive cases showed significantly higher FoxP3 (P = .0232) and lower CCR4 (P = .0214). SIRPα positive cases presented significantly better overall survival than SIRPα negative cases (P = .0132). SIRPα positive cases showed significantly HLA class I (P = .0062), HLA class II (P = .0133), microenvironment PD-L1 (miPD-L1) (P = .0032), and FoxP3 (P = .0229) positivity. In univariate analysis, SIRPα expression was significantly related to prognosis (Hazard ratio [HR] 0.470; 95% confidence interval [CI] 0.253-0.870; P = .0167], although multivariate analysis did not show SIPRα as an independent prognostic factor. The expression of SIRPα on stromal cells reflects activated immune surveillance mechanism in tumor microenvironment and induce good prognosis in ATLL. More detailed studies for gene expression or genomic abnormalities will disclose clinical and biological significance of the CD47 and SIRPα in ATLL. 相似文献
3.
Shota Nukaga Takuya Mori Yoshihiro Miyagawa Rina FujiwaraTani Takamitsu Sasaki Kiyomu Fujii Shiori Mori Kei Goto Shingo Kishi Chie Nakashima Hitoshi Ohmori Isao Kawahara Yi Luo Hiroki Kuniyasu 《Cancer science》2020,111(12):4605
Cancer‐derived myocardial damage is an important cause of death in cancer patients. However, the development of dietary interventions for treating such damage has not been advanced. Here, we investigated the effect of dietary intervention with lauric acid (LAA) and glucose, which was effective against skeletal muscle sarcopenia in a mouse cachexia model, on myocardial damage. Treatment of H9c2 rat cardiomyoblasts with lauric acid promoted mitochondrial respiration and increased ATP production by Seahorse flux analysis, but did not increase oxidative stress. Glycolysis was also promoted by LAA. In contrast, mitochondrial respiration and ATP production were suppressed, and oxidative stress was increased in an in vitro cachexia model in which cardiomyoblasts were treated with mouse cachexia ascites. Ascites‐treated H9c2 cells with concurrent treatment with LAA and high glucose showed that mitochondrial respiration and glycolysis were promoted more than that of the control, and ATP was restored to the level of the control. Oxidative stress was also reduced by the combined treatment. In the mouse cachexia model, myocardiac atrophy and decreased levels of a marker of muscle maturity, SDS‐soluble MYL1, were observed. When LAA in CE‐2 diet was orally administered alone, no significant rescue was observed in the cancer‐derived myocardial disorder. In contrast, combined oral administration of LAA and glucose recovered myocardial atrophy and MYL1 to levels observed in the control without increase in the cancer weight. Therefore, it is suggested that dietary intervention using a combination of LAA and glucose for cancer cachexia might improve cancer‐derived myocardial damage. 相似文献
4.
5.
Chie Teramoto PHN RN MS Satoko Nagata PhD PHN RN Reiko Okamoto PhD PHN RN Ruriko Suzuki PHN RN MS Emiko Kishi PhD PHN RN Michie Nomura DSN PHN RN Noriko Jojima PHN RN MS Masumi Nishida PhD PHN RN Keiko Koide PhD PHN RN Emiko Kusano PhD PHN RN Saori Iwamoto PhD PHN RN Sachiyo Murashima PhD PHN RN 《Public health nursing (Boston, Mass.)》2015,32(6):654-661
6.
Yamaoka Mai Yoshida Mahoko Nakashima Ayumu Doi Shigehiro Naito Takayuki Masaki Takao 《Clinical and experimental nephrology》2022,26(11):1111-1118
Clinical and Experimental Nephrology - The association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and stroke in Japanese hemodialysis (HD) outpatients is unclear. Therefore, in... 相似文献
7.
8.
9.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763