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1.
Alazne Belar Maria Arantzamendi Alfredo Rodríguez-Núñez Yolanda Santesteban Marina Martinez Mario López-Saca Sara Consigli Jesús López-Fidalgo Carlos Centeno 《Journal of pain and symptom management》2019,57(3):627-634
Context
Demoralization is a state of existential distress in patients with advanced illness, typically with coping difficulties, feelings of loss of sense, and purpose in life and despair, among other things. The New Demoralization Scale (DS-II) is an evaluation tool for this syndrome, which has recently been reformulated on a shorter scale.Objectives
The objective of this study was to obtain a Spanish version of the DS-II and to assess its psychometric properties in advanced cancer patients in Spain and a number of Latin American countries.Methods
Following a translation–back translation process, a validation study and a confirmatory analysis using structural equation models with their corresponding latent constructs were undertaken. Patients completed the DS-II in Spanish (DS-II (es)), the Hospital Anxiety and Depression Scale, and the Edmonton Symptom Assessment System–revised. Reliability was studied according to internal consistency; construct validity and concurrent validity with the Hospital Anxiety and Depression Scale and the Edmonton Symptom Assessment System–revised; discriminant validity using the Karnofsky Performance Status scale; and feasibility, with response ratio and required time. Cutoff points were established, and sensitivity and specificity were studied.Results
The DS-II (es) was obtained. One hundred fifty patients completed the validation study. The confirmatory analysis showed coherence, and all items correlated positively with their subscales and with the overall scale. Cronbach's alpha for the DS-II (es) was 0.88, for the sense and purpose subscale 0.83, and for the coping ability 0.79. Demoralization correlated significantly with emotional distress (rho = 0.73, P < 0.001). The tool distinguished between patients with diverse functional levels (rho = ?0.319, P = 0.001). Cutoff points at 10 and 20 out of 32 were established. The scale showed high sensitivity (81.97%) and specificity (80.90%). The prevalence of demoralization was 33% in our sample.Conclusion
The Spanish version of the new Kissane DS-II demoralization scale has shown to be valid, reliable, and feasible with adequate psychometric properties. 相似文献2.
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Diamantis I. Tsilimigras MD Rittal Mehta MPH Alfredo Guglielmi MD Francesca Ratti MD Hugo P. Marques MD Olivier Soubrane MD Vincent Lam MD George A. Poultsides MD Irinel Popescu MD Sorin Alexandrescu MD Guillaume Martel MD Tom Hugh MD Luca Aldrighetti MD Itaru Endo MD PhD Timothy M. Pawlik MD MPH PhD FACS FRACS 《Journal of surgical oncology》2020,122(5):955-963
4.
Ramos-Fresnedo Andres Domingo Ricardo A. Vivas-Buitrago Tito Lundy Larry Trifiletti Daniel M. Jentoft Mark E. Desai Amit B. Quiñones-Hinojosa Alfredo 《Journal of neuro-oncology》2020,149(3):413-420
Journal of Neuro-Oncology - Intracranial meningiomas rarely present with multiple lesions. To the best of our knowledge, current literature regarding meningiomatosis (MM) is mostly comprised of... 相似文献
5.
Carmen Alba-Linero Barbara Romero Victor Llorenç Alfredo Adan Javier Zarranz-Ventura 《Ocular immunology and inflammation》2020,28(2):228-237
ABSTRACTPurpose: To describe the long-term clinical outcomes in a cohort of uveitic eyes treated with the intravitreal dexamethasone implant (Ozurdex; Allergan, Inc).Methods: Seventy-nine (63 patients) receiving 134 implant injections over 82 months were included. Indication, visual acuity (VA), intraocular pressure (IOP), vitreous haze score (VHS), central retinal thickness (CRT), time to reinjection, systemic treatments, and complications data were recorded.Results: The cumulative probability of VA improvement was 80% at 1 month and 90% at 12 months, and it was maintained until 60 months. Eyes with baseline vitritis (VHS >0.5; 68%) had a probability of VHS improvement of 33% at 1 month, 75% at 12 months, and 85% at 60 months. The probability of CRT improvement was 33% at 1 month, 75% at 12 months, and 85% at 60 months. The most frequent adverse event was moderate IOP elevation (≥25 mmHg) in 30.3%, no cases of retinal detachment or endophthalmitis were observed.Conclusions: The dexamethasone implant provides favorable VA, CRT, and VHS long-term outcomes in uveitis with a reduced rate of severe adverse events. 相似文献
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Long noncoding RNAs have been recently demonstrated to have an important role in fundamental biological processes, and their deregulated expression has been found in several human neoplasias. Our group has
recently reported a drastic overexpression of the long noncoding RNA (lncRNA) RPSAP52 (ribosomal protein SA pseudogene 52) in pituitary adenomas. We have shown that this lncRNA increased cell proliferation
by upregulating the expression of the chromatinic proteins HMGA1 and HMGA2, functioning as a competing endogenous RNA (ceRNA) through competitively binding to microRNA-15a (miR-15a), miR-15b, and
miR-16. The aim of this work was to identify further mechanisms by which RPSAP52 overexpression could
contribute to the development of pituitary adenomas. We investigated the involvement of RPSAP52 in the
modulation of the expression of cell cycle-related genes, such as p21Waf1/CIP, whose deregulation plays a
critical role in pituitary cell transformation. We report that RPSAP52, interacting with the RNA binding protein
HuR (human antigen R), favors the delocalization of miR-15a, miR-15b, and miR-16 on the cyclin-dependent
kinase inhibitor p21Waf1/CIP1 that, accordingly, results in downregulation in pituitary adenomas. A RNA
immunoprecipitation sequencing (RIPseq) analysis performed on cells overexpressing RPSAP52 identified 40
messenger RNAs (mRNAs) enriched in Argonaute 2 (AGO2) immunoprecipitated samples. Among them, we
focused on GAS8 (growth arrest-specific protein 8) gene. Consistently, GAS8 expression was downregulated
in all the analyzed pituitary adenomas with respect to normal pituitary and in RPSAP52-overepressing cells,
supporting the role of RPSAP52 in addressing genes involved in growth inhibition and cell cycle arrest to
miRNA-induced degradation. This study unveils another RPSAP52-mediated molecular mechanism in pituitary tumorigenesis. 相似文献
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