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1.
Iori Sato Akiko Higuchi Takaaki Yanagisawa Akitake Mukasa Kohmei Ida Yutaka Sawamura Kazuhiko Sugiyama Nobuhito Saito Toshihiro Kumabe Mizuhiko Terasaki Ryo Nishikawa Yasushi Ishida Kiyoko Kamibeppu 《Quality of life research》2014,23(4):1059-1068
Purpose
To understand the influence of disease and treatment on the health-related quality of life (HRQOL) of children with brain tumors, compared to the HRQOL of children with other cancers, from the viewpoints of children and parents.Methods
A total of 133 children aged 5–18 years and 165 parents of children aged 2–18 completed questionnaires of the Pediatric Quality of Life Inventory Cancer Module (Pain and Hurt, Nausea, Procedural Anxiety, Treatment Anxiety, Worry, Cognitive Problems, Perceived Physical Appearance, and Communication scales); higher scores indicate a better HRQOL. The Cancer Module scores, weighted by age and treatment status, were compared to those obtained in a previous study of children with other cancers (mostly leukemia).Results
The weighted mean scores for Pain and Hurt (effect size d = 0.26) and Nausea (d = 0.23) from child reports and the scores for Nausea (d = 0.28) from parent reports were higher for children with brain tumors than scores for children with other cancers. The scores for Procedural Anxiety (d = ?0.22) and Treatment Anxiety (d = ?0.32) from parent reports were lower for parents of children with brain tumors than the scores for parents of children with other cancers. The child-reported Pain and Hurt score of the Cancer Module was higher (d = 0.29) and in less agreement (intraclass correlation coefficient = 0.43) with scores from the Brain Tumor Module, indicating that assessments completed with the Cancer Module misesteem pain and hurt problems in children with brain tumors.Conclusions
The profiles of cancer-specific HRQOL in children with brain tumors differ from those of children with other cancers; we therefore suggest that these children receive specific psychological support. 相似文献2.
3.
Otani Ryohei Mukasa Akitake Uzuka Takeo Higuchi Fumi Matsuda Hadzki Nomura Masashi Tanaka Shota Kim Phyo Ueki Keisuke 《Journal of neuro-oncology》2021,151(2):221-230
Journal of Neuro-Oncology - Awake surgery is the standard treatment to preserve motor and language functions. This longitudinal study aimed to evaluate the resection rate and preservation of... 相似文献
4.
Mabumi Matsushita Nobukazu Nakasato Haruo Nakagawa Akitake Kanno Yasuhiro Kaiho Naoki Kawamorita Yoichi Arai 《Journal of clinical neuroscience》2009,16(10):1330-1333
Magnetoencephalography (MEG) was used to measure the somatosensory evoked fields in six healthy males undergoing sacral surface therapeutic electrical stimulation, a recently introduced treatment for chronic urinary dysfunction. This study was performed to investigate the utility of MEG to optimize the stimulation parameters. Strong or weak electrical stimuli were applied to small or large surface electrodes placed over the bilateral sacral surfaces. The peak latency and strength of the equivalent current dipole were evaluated at the first peak originating from the primary somatosensory cortex (M30). There was no difference in M30 latency in response to stimulation intensity or electrode size. However, a larger equivalent current dipole strength was obtained in response to higher stimulus intensities, which indicated a more effective stimulus on the sacral surface. The present MEG study shows that stronger stimuli given through large electrodes evoke larger responses than small stimuli through small electrodes. The study also suggests that MEG can be used as an objective tool to monitor whether therapeutic stimulation parameters are appropriate. 相似文献
5.
Naoto Kunoki Ryu Nishiyama Hitomi Ryuzaki Masahiko Oonishi Toshiki Yamamoto Akitake Uno Masahiro Ogawa Akifumi Ogihara Naohide Tanaka Mitsuhiko Moriyama Keio Sou Noriko Kinukawa 《Nihon Shokakibyo Gakkai zasshi》2008,105(10):1489-1495
The patient was a 79-year-old woman. We became introduction consultation than a nearby doctor in alpha-fetoprotein(AFP)high level. Abdominal ultrasonography showed 30mm great tumor in liver lateral segment area and gastric fiber showed type2 tumor which is AFP producing gastric cancer. On admission AFP level is high(403ng/ml). Multiple liver metastases were noted it by abdominal angiography. We started FLAP(5-fluorouracil, leucovorin, etoposide, cisplatin)combination chemotherapy by a diagnosis of AFP producing gastric cancer StageIV. It is reduction of a liver tumor after one course, and the stomach lesion almost disappeared after three courses end points. 相似文献
6.
Hide Takuichiro Shibahara Ichiyo Inukai Madoka Shigeeda Ryota Shirakawa Yuki Jono Hirofumi Shinojima Naoki Mukasa Akitake Kumabe Toshihiro 《Brain tumor pathology》2022,39(2):51-56
Brain Tumor Pathology - The characteristic features of plasticity and heterogeneity in glioblastoma (GB) cells cause therapeutic difficulties. GB cells are exposed to various stimuli from the tumor... 相似文献
7.
Ken Uekawa Yasuyuki Kaku Toshihiro Amadatsu Hiroaki Matsuzaki Yuki Ohmori Takayuki Kawano Shinya Hirata Tomomi Yamaguchi Tomoki Kosho Akitake Mukasa 《Interventional neuroradiology》2021,27(2):212
ObjectiveWe describe a case of intracranial and extracranial multiple arterial dissecting aneurysms in rheumatoid arthritis (RA).Case PresentationA 29-year-old man with a medical history of RA since 18 years of age was admitted to our hospital for vomiting, dysarthria, and conscious disturbance. At 23, he underwent ligation of the left internal carotid artery (ICA) with superficial temporal artery to middle cerebral artery anastomosis because of acute infarct of the left hemisphere caused by arterial dissection of the left ICA. During the current admission, computed tomography (CT) revealed subarachnoid hemorrhage, and digital subtraction angiography (DSA) demonstrated dissecting aneurysms of the left intracranial vertebral artery (VA) and right extracranial VA. We diagnosed him with a ruptured dissecting aneurysm of the left intracranial VA and performed endovascular parent artery occlusion on the left VA. For the right unruptured VA aneurysm, we performed coil embolization simultaneously. At 2 weeks after the endovascular treatment, follow-up DSA revealed that multiple de novo dissecting aneurysms developed on the origin of the left VA and left and right internal thoracic arteries. Those aneurysms were treated with coil embolization. Other remaining aneurysms on the left thyrocervical trunk, right transverse cervical artery, and both common iliac arteries were treated by conservative therapy. While continuing medical treatment for RA, the patient recovered and was discharged to a rehabilitation hospital.ConclusionConsidering that RA-induced vasculitis can be a potential risk of vascular complications including multiple arterial dissections, physicians should carefully perform endovascular interventional procedures for patients with long-term RA. 相似文献
8.
Koki Aihara Akitake Mukasa Kengo Gotoh Kuniaki Saito Genta Nagae Shingo Tsuji Kenji Tatsuno Shogo Yamamoto Shunsaku Takayanagi Yoshitaka Narita Soichiro Shibui Hiroyuki Aburatani Nobuhito Saito 《Neuro-oncology》2014,16(1):140-146
Introduction
Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma. Additionally, H3F3A K27M substitutions occur in gliomas that arise at midline locations (eg, pons, thalamus, spine); moreover, this substitution occurs mainly in tumors in children and adolescents. Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma.Methods
Genomic H3F3A was sequenced from 20 separate thalamic gliomas. Additionally, for 14 of the 20 gliomas, 639 genes—including cancer-related genes and chromatin-modifier genes—were sequenced, and the Infinium HumanMethylation450K BeadChip was used to examine DNA methylation across the genome.Results
Of the 20 tumors, 18 were high-grade thalamic gliomas, and of these 18, 11 were from patients under 50 years of age (median age, 38 y; range, 17–46), and 7 were from patients over 50 years of age. The H3F3A K27M mutation was present in 10 of the 11 (91%) younger patients and absent from all 7 older patients. Additionally, H3F3A K27M was not detected in the 2 diffuse astrocytomas. Further sequencing revealed recurrent mutations in TP53, ATRX, NF1, and EGFR. Gliomas with H3F3A K27M from pediatric or young adult patients had similar, characteristic DNA methylation profiles. In contrast, thalamic gliomas with wild-type H3F3A had DNA methylation profiles similar to those of hemispheric glioblastomas.Conclusion
We found that high-grade thalamic gliomas from young adults, like those from children and adolescents, frequently had H3F3A K27M. 相似文献9.
Zenichi Morise M.D. Ph.D. Atsushi Sugioka M.D. Ph.D. Junko Fujita M.D. Ph.D. Sojun Hoshimoto M.D. Takazumi Kato M.D. Akitake Hasumi M.D. Ph.D. Takashi Suda M.D. Ph.D. Hiromichi Negi M.D. Ph.D. Yoshinobu Hattori M.D. Ph.D. Harunobu Sato M.D. Ph.D. Kotaro Maeda M.D. Ph.D. 《Journal of gastrointestinal surgery》2006,10(1):6-11
Hepatic resection for colorectal metastases was performed for 188 patients. Overall survival rates after the first hepatectomy
are 41.4% and 32.7% for 5 and 10 years, respectively. The survival rate of 116 cases with unilobar hepatic metastases (H1)
is significantly higher than those of 48 cases with two to four bilobar metastases (H2) and 24 cases with more than four (H3),
respectively. However, the differences between the survival rates from H1 with multiple metastases, H2, and H3 are not significant,
even though the H3 group has no 10-year survivors. The 5-year survival rates after the second hepatectomy (30 patients) and
the resection of the lung (26 patients) are 30.3% and 35.2%, respectively, in this series. In those patients, the 5-year survival
rates from the first metastasectomy are 43.4% and 50.3%, respectively. There are 14 5-year survivors with multiple metastases
and 8 of those patients underwent multiple surgeries. There are 13 patients with three or more repeat resections of the liver
and/or lung. The 5-year survival rates of the patients from the first and third metastasectomy are 53.9% and 22.5%, respectively.
Repeat operations for the liver and the lung contribute to the improving prognosis.
Presented at the Forty-Sixth Annual Meeting of The Society for Surgery of the Alimentary Tract, Chicago, Illinois, May 14–18,
2005 (poster presentation). 相似文献
10.
Iori Sato Akiko Higuchi Takaaki Yanagisawa Shiho Murayama Toshihiro Kumabe Kazuhiko Sugiyama Akitake Mukasa Nobuhito Saito Yutaka Sawamura Mizuhiko Terasaki Soichiro Shibui Jun Takahashi Ryo Nishikawa Yasushi Ishida Kiyoko Kamibeppu 《International journal of clinical oncology / Japan Society of Clinical Oncology》2018,23(5):801-811