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Objective: The goal of this study is to systematically assess the effectiveness of acupuncture compared with medication for migraine.Methods: The Cochrane Library, PubMed, MEDLINE, Embase, China National Knowledge Infrastructure(CNKI), Sinomed, the Chongqing VIP full-text periodical database(VIP) and Wanfang were searched by computer to identify the randomized controlled trails comparing acupuncture with medication for migraine from the beginning of these databases to August 2018, supplementing with literature retrospective and manual searches. Review Manager 5.2 was used for statistical analysis.Results: A total of 13 trails including 1218 participants met the selection criteria.(1) The meta-analysis of 3 articles showed that acupuncture was more effective in reducing the frequency of migraine attacks(MD =-2.03; 95% CI:-2.77 to-1.30; P 0.00001) than medication.(2) The meta-analysis of three articles showed that acupuncture was more effective in reducing the number of migraine days(MD =-1.65;95% CI:-2.78 to-0.52; P= 0.004) than medication after treatment.(3) The meta-analysis of six articles showed that acupuncture was more effective in reducing VAS(MD =-1.26; 95% CI:-1.48 to-1.04;P 0.00001) after treatment.(4) The meta-analysis of two articles showed that acupuncture was more effective in reducing VAS(MD =-1.07; 95% Cl:-1.63 to-0.51; P= 0.0002) during follow-up.(5) The meta-analysis of seven articles showed that the total effective rate of acupuncture was higher than that of medication(MD=1.27; 95% Cl: 1.16 to 1.37; P 0.00001). In addition, fewer adverse effects in acupuncture groups were reported than in medication groups. Overall the quality of the evidence was low.Conclusion: The results of this meta-analysis showed that acupuncture is more effective and safer than medication for migraine. Acupuncture can be considered a treatment option for patients willing to undergo this treatment. But more high-quality studies, based on standardized, comprehensive and objective evaluation, are required to enhance the reliability of the conclusion. 相似文献
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目的基于丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路探究桃仁治疗2型糖尿病大血管纤维化大鼠的作用机制。方法雄性SD大鼠200只,随机选取30只为空白对照组,余170只制备2型糖尿病大血管纤维化大鼠模型,分为早期干预组、低剂量组、高剂量组、模型对照组;早期干预组与低剂量组予桃仁颗粒剂水溶液10 m L/(kg·d)灌胃,高剂量组予桃仁颗粒剂水溶液20 m L/(kg·d)灌胃,模型对照组予0. 9%氯化钠10 m L/(kg·d)灌胃,空白对照组不干预,其中早期干预组从2型糖尿病模型成模后随即开始干预,余各组从2型糖尿病大血管纤维化大鼠模型成模后开始干预。药物干预1周、3周及7周后处死并取材。观察大鼠股动脉病理改变,采用Western blotting方法检测股动脉的ERK1/2及p-ERK1/2的表达情况,采用RT-PCR检测MAPK mRNA表达水平。结果 (1) Western blotting方法检测ERK1/2及p-ERK1/2表达比较:空白对照组与其他四组相比,差异有统计学意义(P 0. 05),空白对照组大鼠股动脉ERK1/2、p-ERK1/2表达值最低;第1、3周,早期干预组与其他四组相比,差异有统计学意义(P 0. 05),早期干预组大鼠股动脉ERK1/2、p-ERK1/2表达值低于低剂量组、高剂量组、模型对照组;第7周,早期干预组与高剂量组相比,差异无统计学意义(P 0. 05);第3、7周,低剂量组与高剂量组、模型对照组,高剂量组与模型对照组相比,差异有统计学意义(P 0. 05),高剂量组大鼠股动脉ERK1/2、p-ERK1/2表达值低于低剂量组,低剂量组大鼠股动脉ERK1/2、p-ERK1/2表达值低于模型对照组。(2)大鼠股动脉MAPK mRNA表达组间比较:空白对照组与其他四组相比,差异有统计学意义(P 0. 05),空白对照组大鼠股动脉MAPK mRNA表达量最低;第1、3周,早期干预组与其他四组相比,差异有统计学意义(P 0. 05),早期干预组大鼠股动脉MAPK mRNA表达量低于低剂量组、高剂量组、模型对照组;第7周,早期干预组与高剂量组相比,差异无统计学意义(P 0. 05);第3、7周,低剂量组与高剂量组、模型对照组,高剂量组与模型对照组相比,差异有统计学意义(P 0. 05),高剂量组大鼠股动脉MAPK mRNA表达量低于低剂量组,低剂量组大鼠股动脉MAPK mRNA表达量低于模型对照组。结论桃仁能降低ERK1/2、p-ERK1/2及MAPK mRNA的表达,对糖尿病大血管纤维化病变有改善作用,其作用与剂量和干预时间有相关性。 相似文献
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目的：比较电针四关穴与口服盐酸氟桂利嗪胶囊治疗肝阳上亢型偏头痛的临床疗效。方法：将110例肝阳上亢型偏头痛患者随机分为电针组（55例,脱落2例）和西药组（55例,脱落2例）。电针组予电针四关穴（合谷、太冲）治疗,疏密波,频率2 Hz/100 Hz,电流强度0.1～1 mA,每次30 min,每天1次,每周5次,连续治疗4周。西药组口服盐酸氟桂利嗪胶囊,每次10mg,每天1次,连续服用4周。观察两组治疗前、治疗后及随访1、3、6个月的疼痛视觉模拟量表（VAS）评分、头痛发作天数以及治疗前后偏头痛症状评分。结果：治疗后及随访1、3、6个月时,两组VAS评分和头痛发作天数均较治疗前降低（P<0.05）,且电针组均低于西药组（P<0.05）。治疗后,两组偏头痛症状评分均较治疗前降低（P<0.05）,且电针组降低幅度大于西药组（P<0.05）。结论：电针四关穴治疗肝阳上亢型偏头痛疗效优于口服盐酸氟桂利嗪胶囊,在降低头痛强度、减少头痛发作天数及改善偏头痛症状方面疗效更佳。 相似文献
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