越鞠丸在妇科月经病中的临床应用

越鞠丸治疗妇科月经病，取得了较好的疗效，本方是在正确地辨病辩证情况下使用的，体现了中医辨证论治、异病同治的原则，从而更好地应用于妇科及各科临床。     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

东菱迪芙对大鼠局灶性脑缺血再灌注后JNK和ERK活性的影响

目的探讨东菱迪芙对局灶性脑缺血再灌注大鼠脑内c-Jun氨基末端激酶(JNK)和胞外信号调节酶(ERK)活性的影响。方法采用大脑中动脉线栓法(MCAO)建立大鼠局灶性脑缺血再灌注模型,用免疫组织化学法和免疫印迹法检测ERK和JNK的活性,同时观察缺血侧脑组织形态学变化、脑梗死体积比、凋亡细胞数。结果东菱迪芙可下调脑缺血再灌注大鼠脑组织JNK蛋白的活性,上调ERK蛋白的活性,并降低梗死体积、坏死和凋亡细胞数。结论东菱迪芙对大鼠局灶性脑缺血再灌注损伤有保护作用,抑制JNK凋亡通路、促进ERK生存通路, 从而减轻细胞凋亡是其脑保护机制之一。     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

初诊2型糖尿病短期胰岛素强化治疗方法的临床比较

目的:探讨初诊2型糖尿病短期胰岛素强化治疗的有效方法.方法:60例初诊2型糖尿病患者随机分为胰岛素泵组(A组)、甘精胰岛素组(B组)与诺和灵N组(C组),每组20例.观察各组患者治疗前后各项临床指标变化情况.结果:A和B组空腹及餐后2 h血糖、胰岛素剂量、不良事件、体重增加、血糖达标时间、平均住院日低于C组(P<0.05),A组与B组未见明显差异(P>0.05).B组与C组基础医疗费用明显低于A组(P<0.05),B组与C组未见明显差异(P>0.05).结论:甘精胰岛素组可作为初诊2型糖尿病短期胰岛素强化治疗的首选方法之一.     

浅议导赤散配伍的增效减毒

导赤散通过合理的配伍体现其配伍的增效减毒原理,证实了方剂组方理论的可靠性与真实性,对今后复方的研究有一定实质性指导价值。     

毒性弥漫性甲状腺肿的糖皮质激素治疗现状

毒性弥漫性甲状腺肿（GD）是常见的自身免疫性甲状腺疾病,近年来免疫抑制剂——糖皮质激素（GC）在GD中的应用研究被广泛关注。本文依据文献,对GC治疗GD的适应证、作用机制进行综述,以期为GD时GC的治疗提供参考。     

超声评价通心络对2型糖尿病早期左室功能的影响

目的用超声评价通心络对2型糖尿病早期左心室功能的保护作用。方法将80例早期2型糖尿病患者随机分为常规治疗组40例和通心络治疗组40例,比较两组治疗前及治疗24周后左心室收缩功能指标（Sa、SRs）、舒张功能指标（Ea/Aa、SRe/SRa）及Tei指数。结果 （1）治疗前两组左室功能指标差异无统计学意义（P〉0.05）;（2）常规治疗后Ea/Aa、SRe/SRa、SRs、Sa轻度升高,Tei指数轻度下降,但与治疗前比较差异无统计学意义（P〉0.05）;（3）通心络治疗后Ea/Aa、SRe/SRa、SRs、Sa显著升高,Tei指数显著下降,与治疗前比较差异有统计学意义（P〈0.05）。结论通心络能有效改善2型糖尿病早期左心室功能;超声可用于早期2型糖尿病患者左心室功能的检测及药物疗效的评估。