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1.
Sibylle M. Winter Katja Dittrich Peggy Dörr Judith Overfeld Imke Moebus Elena Murray Gergana Karaboycheva Christian Zimmermann Andrea Knop Manuel Voelkle Sonja Entringer Claudia Buss John-Dylan Haynes Elisabeth B. Binder Christine Heim 《Journal of child psychology and psychiatry, and allied disciplines》2022,63(9):1027-1045
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Cornelius Anna Pilger Daniel Riechardt Aline Reitemeyer Emanuel Rübsam Anne Winterhalter Sibylle Maier Anna-Karina B. 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(3):957-965
Graefe's Archive for Clinical and Experimental Ophthalmology - To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical... 相似文献
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Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking 下载免费PDF全文
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Abu Sin Muna Nahrgang Saskia Ziegelmann Antina Clarici Alexandra Matz Sibylle Tenhagen Bernd-Alois Eckmanns Tim 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(5):507-514
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Die Ausbreitung von Antibiotikaresistenzen wurde in den letzten Jahren zunehmend als Problem im Bereich globale Gesundheit... 相似文献
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Kuangyu Shi Christine Bayer Sabrina T. Astner Florian C. Gaertner Peter Vaupel Markus Schwaiger Sung-Cheng Huang Sibylle I. Ziegler 《Molecular imaging and biology》2017,19(1):120-129
Purpose
Quantitative evaluation of tumor hypoxia based on H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole ([18F]FMISO) positron emission tomography (PET) can deliver important information for treatment planning in radiotherapy. However, the merits and limitations of different analysis methods in revealing the underlying physiological feature are not clear. This study aimed to assess these quantitative analysis methods with the support of immunohistological data.Procedures
Sixteen nude mice bearing xenografted human squamous cell carcinomas (FaDu or CAL-33) were scanned using 2-h dynamic [18F]FMISO PET. Tumors were resected and sliced, and the hypoxia marker pimonidazole was immunostained followed by H&E staining. The pimonidazole signal was segmented using a k-means clustering algorithm, and the hypoxic fraction (HF) was calculated as the hypoxic area/viable tumor-tissue-area ratio pooled over three tissue slices from the apical, center, and basal layers. PET images were analyzed using various methods including static analysis [standard uptake value (SUV), tumor-to-blood ratio (T/B), tumor-to-muscle ratio (T/M)] and kinetic modeling (Casciari αk A , irreversible and reversible two-tissue compartment k 3, Thorwarth w A k 3, Patlak K i , Logan V d , Cho K), and correlated with HF.Results
No significant correlation was found for static analysis. A significant correlation between k 3 of the irreversible two-tissue compartment model and HF was observed (r?=?0.61, p?=?0.01). The correlation between HF and αk A of the Casciari model could be improved through reducing local minima by testing more sets of initial values (r?=?0.59, p?=?0.02) or by reducing the model complexity by fixing three parameters (r?=?0.63, p?=?0.0008).Conclusions
With support of immunohistochemistry data, this study shows that various analysis methods for [18F]FMISO PET perform differently for assessment of tumor hypoxia. A better fitting quality does not necessarily mean a higher physiological correlation. Hypoxia PET analysis needs to consider both the mathematical stability and physiological fidelity. Based on the results of this study, preference should be given to the irreversible two-tissue compartment model as well as the Casciari model with reduced parameters.8.
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Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting 下载免费PDF全文