全文获取类型
收费全文 | 299篇 |
免费 | 11篇 |
专业分类
儿科学 | 19篇 |
妇产科学 | 6篇 |
基础医学 | 48篇 |
口腔科学 | 3篇 |
临床医学 | 22篇 |
内科学 | 85篇 |
皮肤病学 | 11篇 |
神经病学 | 22篇 |
特种医学 | 1篇 |
外科学 | 18篇 |
综合类 | 12篇 |
预防医学 | 16篇 |
眼科学 | 17篇 |
药学 | 14篇 |
中国医学 | 2篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 5篇 |
2022年 | 2篇 |
2021年 | 25篇 |
2020年 | 10篇 |
2019年 | 12篇 |
2018年 | 16篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 14篇 |
2012年 | 30篇 |
2011年 | 36篇 |
2010年 | 10篇 |
2009年 | 6篇 |
2008年 | 11篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 3篇 |
2004年 | 5篇 |
2003年 | 8篇 |
2002年 | 4篇 |
2001年 | 4篇 |
2000年 | 8篇 |
1999年 | 3篇 |
1997年 | 1篇 |
1995年 | 4篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有310条查询结果,搜索用时 46 毫秒
1.
Lung - Epoprostenol, a synthetic prostaglandin I2 (PGI2) analog, has been the mainstay of treatment for severe pulmonary arterial hypertension (PAH) for the last two decades. Treprostinil, another... 相似文献
2.
3.
Evaluation of high‐fat high‐fructose diet treatment in factor VIII (coagulation factor)‐deficient mouse model 下载免费PDF全文
Alaknanda Mishra Shailendra Arindkar Preeti Sahay Jerald Mahesh Kumar Pramod K. Upadhyay Subeer S. Majumdar Perumal Nagarajan 《International journal of experimental pathology》2018,99(1):46-53
Non‐alcoholic fatty liver disease (NAFLD)‐like conditions enhance the production and action of clotting factors in humans. However, studies examining the effect of NAFLD due to high‐fat high‐fructose (HFHF) diet in factor VIII‐deficient (haemophilia A) animals or patients have not been reported previously. In this study, we investigated the individual role of factor VIII in the progression of diet‐induced NAFLD in the factor 8?/? (F8?/?) mouse model system and its consequences on the haemophilic status of the mice. The F8?/? mice were fed with HFHF diet for 14 weeks. Physiological, biochemical, haematological, molecular, pathological, and immune histochemical analyses were performed to evaluate the effect of this diet. The F8?/? mice developed hepatic steatosis after 14 weeks HFHF diet and displayed lower energy metabolism, higher myeloid cell infiltration in the liver, decreased platelet count, upregulated de novo fatty acid synthesis, lipid accumulation, and collagen deposition. This study helps to understand the role of factor VIII in NAFLD pathogenesis and to analyse the severity and consequences of steatosis in haemophilic patients as compared to normal population. This study suggests that haemophilic animals (F8?/? mice) are highly prone to hepatic steatosis and thrombocytopenia. 相似文献
4.
MacQueen KM Namey E Chilongozi DA Mtweve SP Mlingo M Morar N Reid C Ristow A Sahay S;HPTN Standard of Care Assessment Team 《AIDS care》2007,19(4):554-560
There is on-going global debate and policy-setting concerning researchers' obligations to meet the health needs of people participating in HIV prevention trials in resource-poor settings. The perspectives of local community stakeholders on this issue are poorly understood as most of what is presented on behalf of communities where research takes place is anecdotal commentary. Using qualitative methods (130 in-depth interviews and 20 focus groups) we assessed perceived fairness of different strategies to meet the health needs of women who become HIV-infected during a hypothetical vaginal microbicide trial. Respondents included HIV prevention research participants, community stakeholders and health-care service providers in ten sites in seven countries (South Africa, Malawi, Tanzania, Zimbabwe, Zambia, India, US). Many respondents perceived referrals to be a potentially fair way to address care and treatment needs but concerns were also voiced about the adequacy of local health-care options and the ability of trial participants to access options. Most respondents viewed the provision of antiretroviral treatment by researchers to HIV-infected trial participants as unfair if treatment was not sustained beyond the end of the trial. The results underscore the importance of effectively linking trial participants to sustainable, community-based treatment and care. 相似文献
5.
Gupta Tejpal Maitre Madan Gupta Priyamvada Krishnatry Rahul Chatterjee Abhishek Moiyadi Aliasgar Shetty Prakash Singh Vikas Chinnaswamy Girish Epari Sridhar Sahay Ayushi Patil Vijay GodaSastri Jayant 《Journal of neuro-oncology》2020,147(2):405-415
Journal of Neuro-Oncology - To report clinical outcomes of salvage re-irradiation (re-RT) in recurrent/progressive ependymoma. Medical records of patients treated with curative-intent re-RT as... 相似文献
6.
Anju Sinha Nomita Chandhiok Seema Sahay Sibnath Deb Shalini Bharat Abhilasha Gupta 《AIDS care》2015,27(9):1196-1198
A compelling case for promoting male circumcision (MC) as an intervention for reducing the risk of heterosexually acquired HIV infection was made by dissemination of the results of three studies in Africa. The WHO/UNAIDS recommendation for MC for countries like India, where the epidemic in concentrated in high-risk groups, advocates MC for specific population groups such as men at higher risk for HIV acquisition. A multicentre qualitative study was conducted in four geographically distinct districts (Belgaum, Kolkata, Meerut and Mumbai) in India during June 2009 to June 2011. Two categories of health care providers: Registered Healthcare Providers (RHCPs) and traditional circumcisers were interviewed by trained research staff who had received master's level education using interview guides with probes and open-ended questions. Respondents were selected using purposive sampling. A comparative analysis of the perspectives of the RHCP vs. traditional circumcisers is presented. Representatives of both categories of providers expressed the need for Indian data on MC. Providers feared that promoting circumcision might jeopardize/undermine the progress already made in the field of condom promotion. Reservation was expressed regarding its adoption by Hindus. Behavioural disinhibition was perceived as an important limitation. A contrast in the practice of circumcision was apparent between the traditional and the trained providers. MC should be mentioned as a part of comprehensive HIV prevention services in India that includes HIV counselling and testing, condom distribution and diagnosis and treatment of sexually transmitted infections. It should become an issue of informed personal choice rather than ethnic identity. 相似文献
7.
8.
Dustin A. Heldman PhD Joseph P. Giuffrida PhD Robert Chen MBBChir MSc FRCPC Megan Payne MS MBA Filomena Mazzella BScN RN Andrew P. Duker MD Alok Sahay MD Sang Jin Kim MD Fredy J. Revilla MD Alberto J. Espay MD MSc 《Movement disorders》2011,26(10):1859-1863
Bradykinesia encompasses slowness, decreased movement amplitude, and dysrhythmia. Unified Parkinson's Disease Rating Scale–based bradykinesia‐related items require that clinicians condense abnormalities in speed, amplitude, fatiguing, hesitations, and arrests into a single score. The objective of this study was to evaluate the reliability of a modified bradykinesia rating scale, which separately assesses speed, amplitude, and rhythm and its correlation with kinematic measures from motion sensors. Fifty patients with Parkinson's disease performed Unified Parkinson's Disease Rating Scale–directed finger tapping, hand grasping, and pronation–supination while wearing motion sensors. Videos were rated blindly and independently by 4 clinicians. The modified bradykinesia rating scale and Unified Parkinson's Disease Rating Scale demonstrated similar inter‐ and intrarater reliability. Raters placed greater weight on amplitude than on speed or rhythm when assigning a Unified Parkinson's Disease Rating Scale score. Modified bradykinesia rating scale scores for speed, amplitude, and rhythm correlated highly with quantitative kinematic variables. The modified bradykinesia rating scale separately captures bradykinesia components with interrater and intrarater reliability similar to that of the Unified Parkinson's Disease Rating Scale. Kinematic sensors can accurately quantify speed, amplitude, and rhythm to aid in the development and evaluation of novel therapies in Parkinson's disease. © 2011 Movement Disorder Society 相似文献
9.
10.