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排序方式： 共有3995条查询结果，搜索用时 15 毫秒
1.
Kaustubh Supekar Weidong Cai Rajeev Krishnadas Lena Palaniyappan Vinod Menon 《Neuropsychopharmacology》2019,85(1):60-69
Background
Schizophrenia is a highly disabling psychiatric disorder characterized by a range of positive “psychosis” symptoms. However, the neurobiology of psychosis and associated systems-level disruptions in the brain remain poorly understood. Here, we test an aberrant saliency model of psychosis, which posits that dysregulated dynamic cross-network interactions among the salience network (SN), central executive network, and default mode network contribute to positive symptoms in patients with schizophrenia.Methods
Using task-free functional magnetic resonance imaging data from two independent cohorts, we examined 1) dynamic time-varying cross-network interactions among the SN, central executive network, and default mode network in 130 patients with schizophrenia versus well-matched control subjects; 2) accuracy of a saliency model–based classifier for distinguishing dynamic brain network interactions in patients versus control subjects; and 3) the relation between SN-centered network dynamics and clinical symptoms.Results
In both cohorts, we found that dynamic SN-centered cross-network interactions were significantly reduced, less persistent, and more variable in patients with schizophrenia compared with control subjects. Multivariate classification analysis identified dynamic SN-centered cross-network interaction patterns as factors that distinguish patients from control subjects, with accuracies of 78% and 80% in the two cohorts, respectively. Crucially, in both cohorts, dynamic time-varying measures of SN-centered cross-network interactions were correlated with positive, but not negative, symptoms.Conclusions
Aberrations in time-varying engagement of the SN with the central executive network and default mode network is a clinically relevant neurobiological signature of psychosis in schizophrenia. Our findings provide strong evidence for dysregulated brain dynamics in a triple-network saliency model of schizophrenia and inform theoretically motivated systems neuroscience approaches for characterizing aberrant brain dynamics associated with psychosis. 相似文献2.
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Hon Mei Yee Chua Xin Yun Premakumar Chandini Menon Mohamed Shah Noraida 《International journal of clinical pharmacy》2020,42(3):948-955
International Journal of Clinical Pharmacy - Background Drug-related problems are relatively common among hospitalised patients and may be detrimental to patients and even increase healthcare... 相似文献
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Vivek Ashoka Menon Elissa Tong Dana Rose-Marie Louise Slape Tai Anh Phan Renee CF Chan 《The Australasian journal of dermatology》2020,61(1):e97-e99
Dermatitis artefacta is a self-inflicted cutaneous disease presenting as sharply delineated ulcers, usually in accessible sites such as the head and neck. IgG4-related disease (IgG4-RD) is a recently recognised immune-mediated condition causing a fibroinflammatory process, resulting in the formation of tumefactive lesions in various organs, rarely presenting primarily in the skin. We report a case of cutaneous IgG4-RD clinically presenting as dermatitis artefacta. 相似文献
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Frontera Jennifer Mainali Shraddha Fink Ericka L. Robertson Courtney L. Schober Michelle Ziai Wendy Menon David Kochanek Patrick M. Suarez Jose I. Helbok Raimund McNett Molly Chou Sherry H.-Y. 《Neurocritical care》2020,33(1):25-34
Neurocritical Care - As the COVID-19 pandemic developed, reports of neurological dysfunctions spanning the central and peripheral nervous systems have emerged. The spectrum of acute neurological... 相似文献
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