全文获取类型
收费全文 | 36266篇 |
免费 | 2687篇 |
国内免费 | 115篇 |
专业分类
耳鼻咽喉 | 571篇 |
儿科学 | 1144篇 |
妇产科学 | 814篇 |
基础医学 | 5238篇 |
口腔科学 | 2766篇 |
临床医学 | 2880篇 |
内科学 | 7596篇 |
皮肤病学 | 882篇 |
神经病学 | 2753篇 |
特种医学 | 860篇 |
外国民族医学 | 1篇 |
外科学 | 4565篇 |
综合类 | 379篇 |
一般理论 | 10篇 |
预防医学 | 3852篇 |
眼科学 | 618篇 |
药学 | 2431篇 |
中国医学 | 309篇 |
肿瘤学 | 1399篇 |
出版年
2023年 | 293篇 |
2022年 | 315篇 |
2021年 | 1163篇 |
2020年 | 871篇 |
2019年 | 1231篇 |
2018年 | 1364篇 |
2017年 | 1006篇 |
2016年 | 1032篇 |
2015年 | 1181篇 |
2014年 | 1540篇 |
2013年 | 1857篇 |
2012年 | 2696篇 |
2011年 | 3005篇 |
2010年 | 1664篇 |
2009年 | 1227篇 |
2008年 | 2033篇 |
2007年 | 1991篇 |
2006年 | 1864篇 |
2005年 | 1583篇 |
2004年 | 1407篇 |
2003年 | 1293篇 |
2002年 | 1177篇 |
2001年 | 870篇 |
2000年 | 994篇 |
1999年 | 744篇 |
1998年 | 233篇 |
1997年 | 157篇 |
1996年 | 170篇 |
1995年 | 158篇 |
1994年 | 129篇 |
1993年 | 108篇 |
1992年 | 362篇 |
1991年 | 341篇 |
1990年 | 319篇 |
1989年 | 303篇 |
1988年 | 242篇 |
1987年 | 200篇 |
1986年 | 176篇 |
1985年 | 185篇 |
1984年 | 142篇 |
1983年 | 115篇 |
1982年 | 69篇 |
1979年 | 123篇 |
1978年 | 96篇 |
1975年 | 74篇 |
1974年 | 86篇 |
1973年 | 88篇 |
1970年 | 79篇 |
1969年 | 74篇 |
1967年 | 67篇 |
排序方式: 共有10000条查询结果,搜索用时 171 毫秒
1.
Crozeta Bruno Monguilhott Lopes Fabiane Carneiro Menezes Silva Renato Silva-Sousa Yara Teresinha Correa Moretti Letícia Freiria Sousa-Neto Manoel Damião 《Clinical oral investigations》2021,25(3):891-899
Clinical Oral Investigations - The aim of this study was to evaluate the efficacy of supplementary techniques (ultrasonic tip/XP-endo Finisher R) in removing remaining filling materials... 相似文献
2.
Antonio Montalvo Afonso Fernando Ruiz Juretschke Rosario González Rodrigálvarez Olga Mateo Sierra Begoña Iza Vallejo Roberto García Leal Marc Valera Melé Vicente Casitas Hernando Jose Manuel Hernández Poveda Carlos Fernández Carballal 《Neurocirugía (Asturias, Spain)》2021,32(1):1-9
Background and objectivesThe treatment of deafferentation pain by spinal DREZotomy is a proven therapeutic option in the literature. In recent years, use of DREZotomy has been relegated to second place due to the emergence of neuromodulation therapies. The objectives of this study are to demonstrate that DREZotomy continues to be an effective and safe treatment and to analyse predictive factors for success.Patients and methodsA retrospective study was conducted of all patients treated in our department with spinal DREZotomy from 1998 to 2018. Bulbar DREZotomy procedures were excluded. A visual analogue scale (VAS) and the reduction of routine medication were used as outcome variables. Demographic, clinical and operative variables were analysed as predictive factors for success.ResultsA total of 27 patients (51.9% female) with a mean age of 53.7 years underwent DREZotomy. The main cause of pain was brachial plexus injury (BPI) (55.6%) followed by neoplasms (18.5%). The mean time of pain evolution was 8.4 years with a mean intensity of 8.7 according to the VAS, even though 63% of the patients had previously received neurostimulation therapy. Favourable outcome (≥ 50% pain reduction in the VAS) was observed in 77.8% of patients during the postoperative period and remained in 59.3% of patients after 22 months average follow-up (mean reduction of 4.9 points). This allowed for a reduction in routine analgesic treatment in 70.4% of them. DREZotomy in BPI-related pain presented a significantly higher success rate (93%) than the other pathologies (41.7%) (p = .001). No association was observed between outcome and age, gender, DREZ technique, duration of pain or previous neurostimulation therapies. There were six neurological complications, four post-operative transient neurological deficits and two permanent deficits.ConclusionDorsal root entry zone surgery is effective and safe for treating patients with deafferentation pain, especially after brachial plexus injury. It can be considered an alternative treatment after failed neurostimulation techniques for pain control. However, its indication should be considered as the first therapeutic option after medical therapy failure due to its good long-term results. 相似文献
3.
4.
Rizzo Manglio Miguel Bluthgen Mara Virginia Recondo Gonzalo Naveira Martin Perfetti Aldo Rizzi Florencia Kuzminin Alejandro Faura Victoria Cerini Matas Videla Alejandro Silva Carlos Lupinacci Lorena Minatta Nicols 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(6):1057-1064
International Journal of Clinical Oncology - Immune-checkpoint inhibitors (ICIs) are standard treatments for metastatic non-small cell lung cancer (NSCLC). Patients with poor performance status... 相似文献
5.
Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva Thayn Weiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio 《中国神经再生研究》2021,16(5):805
A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke. Thus, strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients. Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations. However, little is reported on this in post-stroke patients. The purpose of this study was to investigate the effect of a single exercise session with Walk Aide functional electrical stimulation(FES) on cognitive performance, clinical functional parameters, oxidative stress and epigenetic modulation in post-stroke individuals. In this crossover design study, 12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes) without Walk Aide functional electrical stimulation(EXE alone group), followed by another single session of exercise(45 minutes) with Walk Aide functional electrical stimulation(EXE + FES group). The clinical functional outcome measures, cognitive performance and blood collections for biomarker measurements were assessed pre-and post-intervention. After intervention, higher Berg Balance Scale scores were obtained in the EXE + FES group than in the EXE alone group. There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE + FES groups. After intervention, a better cognitive performance was found in both groups compared with before the intervention. After intervention, the Timed Up and Go test scores were higher in the EXE + FES group than in the EXE alone group. In addition, the intervention induced lower levels of lipid peroxidation. After intervention, carbonyl level was lower, superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE + FES group, compared with the EXE group alone. In each group, both histone deacetylase(HDAC2) and histone acetyltransferase activities were increased after intervention compared with before the intervention. These findings suggest that a single exercise session with Walk Aide FES is more effective on balance ability and cognitive performance compared with conventional exercise alone in post-stroke patients. This is likely to be related to the regulation of oxidative stress markers. The present study was approved by the Research Ethics Committee of the Methodist University Center-IPA(approval No. 2.423.376) on December 7, 2017 and registered in the Brazilian Registry of Clinical Trials—Re BEC(RBR-9 phj2 q) on February 11, 2019. 相似文献
6.
T.F. Faro E.D. de Oliveira e Silva G.J. Campos N.M. Duarte A.M.M. Caetano J.R. Laureano Filho 《International journal of oral and maxillofacial surgery》2021,50(3):349-355
Throat packs are commonly used in maxillofacial surgeries. However, the evidence to support the benefits of their use is controversial. The aim of this study was to evaluate the effectiveness of throat packs in preventing postoperative nausea and vomiting, and their influence on the incidence of sore throat and dysphagia in patients undergoing orthognathic surgery. This was a prospective double-blind randomized study with 54 patients, who were randomized to two groups: with throat pack (n = 27) and without throat pack (n = 27). Fifty patients (25 in each group) were included in the analysis; 66% female and 34% male, mean age 29.44 ± 8.53 years. Postoperative nausea and vomiting (Kortilla scale), sore throat (visual analogue scale), and dysphagia were evaluated. Statistically significant differences in favour of the without-pack group were found for the variables throat pain at 24 hours (P = 0.002) and dysphagia at 2 hours (P = 0.007) and 24 hours (P < 0.001). There was no difference between the groups regarding postoperative nausea and vomiting (P = 1.00). The results of this study indicate that throat packs as utilized here do not prevent postoperative nausea and vomiting and are associated with worse sore throats and postoperative dysphagia. 相似文献
7.
8.
Del Lama Rafael Silva Candido Raquel Mariana Chiari-Correia Natália Santana Nogueira-Barbosa Marcello Henrique de Azevedo-Marques Paulo Mazzoncini Tinós Renato 《Journal of digital imaging》2022,35(3):446-458
Journal of Digital Imaging - Vertebral Compression Fracture (VCF) occurs when the vertebral body partially collapses under the action of compressive forces. Non-traumatic VCFs can be secondary to... 相似文献
9.
10.
R. López Ruiz S. Quintas P. Largo M. de Toledo M.T. Carreras A. Gago-Veiga R. Manzanares J. Vivancos 《Neurología (Barcelona, Spain)》2019,34(2):73-79