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排序方式: 共有1520条查询结果,搜索用时 15 毫秒
1.
Huang Kangmo Zha Mingming Gao Jie Du Juan Liu Rui Liu Xinfeng 《Journal of thrombosis and thrombolysis》2021,51(2):536-544
Journal of Thrombosis and Thrombolysis - The impact of atrial fibrillation (AF) on outcomes of mechanical thrombectomy (MT) for acute ischemic stroke (AIS) is controversial, and with a paucity of... 相似文献
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Ye Tao Qi Zhu Liqiang Wang Xiaobing Zha Dengke Teng Lei Xu 《Fundamental & clinical pharmacology》2020,34(1):131-147
Retinal degeneration (RD) results in photoreceptor loss and irreversible visual impairments. This study sought to alleviate the photoreceptor degeneration via the adeno-associated virus (AAV)-mediated erythropoietin (EPO) therapy. AAV-2/2-mCMV-EPO vectors were constructed and delivered into the subretinal space of a RD model. The retinal morphology, optokinetic behaviour and electrophysiological function of the treated animals were analysed. The subretinal delivery of AAV-2/2 vectors induced robust EPO gene expressions in the retinas. AAV2/2-mediated EPO therapy ameliorated the photoreceptor degeneration and visual impairments of the RD animal model. Furthermore, the multi-electrodes array (MEA) was used to detect the firing activities of retinal ganglion cells. MEA recording showed that the EPO therapy could restrain the spontaneous firing response, enhance the light-induced firing response and preserve the basic configurations of visual signal pathway in RD model. Our MEA assay provided an example to evaluate the potency of pharmacological compounds on retinal plasticity. In conclusion, AAV2/2-mediated EPO therapy can ameliorate the photoreceptor degeneration and rectify the abnormities in visual signal transmission. These beneficial results suggest the AAV vector is a viable therapeutic option for retinopathies with rapidly degenerating kinetics and lay the groundwork for future development of EPO gene therapy. 相似文献
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He Li BCh Hongmei Zeng PhD Rongshou Zheng MPH Xiaonong Zou MD Maomao Cao BCh Dianqin Sun BCh Jinyi Zhou MPH Pengfei Luo MPH Shangchun Jia BCh Zhenqiu Zha PhD Jialin Wang BCh Hengmin Ma MPH Xibin Sun BCh Xiaoqin Cao PhD Shixian Feng BCh Lei Fan MPH Jufang Shi PhD Wanqing Chen PhD 《Cancer》2020,126(20):4563-4571
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Gluteal muscle contracture (GMC), presented with hip abduction and external rotation when crouching, is common in several ethnicities, particularly in Chinese. It remains unclear that the reasons why these children are weak and have no choice to accept repeated intramuscular injection. Here, we found some unique cases which may be useful to explain this question.We describe a series of special GMC patients, who are accompanied with congenital heart disease (CHD). These cases were first observed in preoperative examinations of a patient with atrial septal defect (ASD), which was proved by chest X-ray and cardiac ultrasound. From then on, we gradually identified additional 3 GMC patients with CHD. The original patient with ASD was sent to cardiosurgery department to repair atrial septal first and received arthroscopic surgery later. While the other 3 were cured postoperative of ventricular septal defect (VSD), tetralogy of fallot (TOF), patent ductus arteriosus (PDA), respectively, and had surgery directly.The study gives us 3 proposals: (1) as to CHD children, it is essential to decrease the use of intramuscular injection, (2) paying more attention to cardiac examination especially cardiac ultrasound in perioperative period, and (3) taking 3D-CT to reconstruct gluteal muscles for observing contracture bands clearly in preoperation. However, more larger series of patients are called for to confirm these findings. 相似文献
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Ju-Fang Shi PhD Le Wang PhD Jian-Chao Ran MPH Hong Wang MB Cheng-Cheng Liu MB Hai-Zeng Zhang MD Lin Yang MD Su-Sheng Shi MD Li-Ming Jiang MD Jin-Hu Fan BS Yue-Ming Zhang MD Wei-Hu Wang MD Jian-Song Ren PhD Lin Zhu MPH Zhao-Xu Zheng MD Yong-Kun Sun MD Shuang-Mei Zou MD Jun Jiang MD Bo Chen MD Hong-Da Chen PhD Guo-Xiang Liu PhD Li Yang PhD Yun-Chao Huang MD Lan-Wei Guo PhD De-Bin Wang PhD Yong-Zhen Zhang MPH A-Yan Mao MPH Jia-Lin Wang MD Ji-Yong Gong MD Dong-Hua Wei MD Wu-Qi Qiu PhD Bing-Bing Song MPH Kai Zhang MD Ni Li PhD Eleonora Feletto PhD Jie-Bin Lew PhD You-Lin Qiao PhD Wan-Qing Chen PhD Min Dai PhD Jie He MD 《Cancer》2021,127(11):1880-1893
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PurposeA meta-analysis aimed to systematically evaluate the safety and efficiency of I125 irradiation stent placement for patients with hepatocellular carcinoma (HCC) combined with portal vein tumor thrombosis (PVTT).Materials and methodsThe Cochrane library, PubMed/Medline, EMBASE, CNKI, Wanfang Data and CQVIP were systematically screened out from the earliest to December 2019. The qualities of all included studies were assessed. The primary endpoints were the 6-month, 12-month stent cumulative patency rate and 6-month, 12-month, 24-month overall survival rate while the secondary endpoints were the objective response rate of PVTT, main portal venous pressure changes and treatment-related adverse events. Our meta-analysis was conducted using Stata 12.0 software.ResultsTotally seven studies with 1018 patients were included in the final analysis, in which 602 patients received TACE and I125 irradiation stent placement, and 416 patients in control group underwent TACE and stent placement without endovascular brachytherapy (EVBT). Meta-analysis showed that the I125 irradiation stent improved the cumulative stent patency rates in 6 months [OR = 1.65, 95% CI (1.32–2.05), P < 0.001] and 12 months [OR = 2.55, 95% CI (1.90–3.42), P < 0.001] and the survival rates in 6 months [OR = 1.77, 95% CI (1.41–2.22), P < 0.001], 12 months [OR = 3.14, 95% CI (2.24–4.40), P < 0.001] and 24 months [OR = 7.39, 95% CI (3.55–15.41), P < 0.001]. However, there was no difference in the objective response rate of PVTT [OR = 1.13, 95% CI (0.87–1.48), P = 0.365], main portal venous pressure and the occurrence adverse event [OR = 0.88, CI = 0.72–1.08, P = 0.212] between two groups.ConclusionI125 irradiation stent seems to be more effective in treating hepatocellular carcinoma with portal vein tumor thrombosis. The usage of portal vein stent combined endovascular brachytherapy has the potential to act as an alternative therapy for HCC with PVTT. On account of the limitation of studies included, more studies with high-level evidence, such as RCTs, are requisite to support the above promising results. 相似文献
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创伤后肘关节僵硬553例回顾性分析 总被引:4,自引:0,他引:4
目的 研究创伤后肘关节僵硬的发病情况.方法 收集1997年1月至2013年12月北京积水潭医院收治的553例创伤后肘关节僵硬患者的病历资料进行回顾性研究.记录患者的临床资料和影像学资料.结果 553例中男性366例,女性187例;平均年龄为35岁(12 ~ 76岁),以>30 ~40岁年龄组的患者最多(166例,占30.8%).中低能量损伤301例(54.4%),高能量损伤227例(41.1%);关节外骨折、损伤60例(10.8%),平均固定时间6.1周,关节内骨折、脱位493例(89.2%),平均固定时间4.9周;肘关节活动范围平均30°(0°~110°);肘部有异位骨化者457例(82.6%),无异位骨化96例(17.4%).结论 创伤后肘关节僵硬通常累及年轻、活跃人群,在临床工作中应重视低能量损伤、关节外骨折和简单关节内骨折的治疗,避免超过3周的制动,采取适当的手术固定方式,早期进行以主动功能锻炼为主,辅以轻柔的被动练习,另外需积极应对异位骨化的发生. 相似文献