自体骨髓移植治疗股骨头无菌性坏死

目的 探讨自体骨髓移植治疗股骨头坏死的疗效及其作用机制.方法 选用成年新西兰雄兔60只,造模后随机分为A、B、C三组.左侧股骨头作为对照组,不予处理,右侧为实验组.A组用米托蒽蓖按0.1 mg/kg量在数字减影型x射线机(DSA)导视下注入右侧股骨头内;B组在DSA下直接注入自体骨髓1 ml;C组先予以化疗(方法同A组),72h后注入自体骨髓1 ml.4个月后处死所有动物,取股骨头进行组织病理学及电镜观察.结果 A、B组内左右股骨头对比破骨细胞坏死数差异无统计学意义(P>0.05),而c组左右股骨头坏死数分别为40.60±4.11、21.23± 2.16,差异有统计学意义(P<0.05).C实验组镜下见大部分骨细胞结构清晰、完整,偶见坏死.结论 局部化疗+自体骨髓移植在细胞水平上对股骨头无菌性坏死具有一定的治疗作用.     

乙状结肠直肠吻合后乙状结肠代膀胱术51例分析

目的 观察Roux-en-Y乙状结肠直肠吻合后乙状结肠代膀胱术可控性尿流改道的临床疗效.方法 对51例膀胱癌患者行Roux-en-Y乙状结肠直肠吻合后乙状结肠代膀胱术.距直肠前壁腹膜返折部15～18 cm处切断乙状结肠,将近端拉入盆腔与直肠上段做端侧吻合,输尿管做成乳头分别与远端乙状结肠吻合.结果 术后患者尿控率100%,无尿失禁,未发生明显酸碱平衡紊乱.1例63岁女性患者发生盆腔引流管处脓肿,1例80岁患者切口液化、裂开,后并发脑出血,脑疝死亡.其余无明显并发症出院术后随访3～60个月,死亡5例,3例死于盆腔复发,1例死于肺转移,2例高龄患者死因不祥.6例患者术后出现轻度高氯性酸中毒,口服碱性药物后恢复.1例患者术后发现尿囊内鸽蛋大结石并双肾积水,切开尿囊取石后,积水减轻,肾功能改善.结论 Roux-en-Y乙状结肠直肠吻合后乙状结肠代膀胱术并发症低、尿控效果好,是一种生理干扰小、安全并简单易行的尿流改道方法.     

TVT术治疗女性压力性尿失禁临床分析

目的评价无张力阴道吊带术T(VT)治疗女性压力性尿失禁疗效。方法经临床检查确诊为女性压力性尿失禁患者28例,采用聚丙烯网状吊带,手术自阴道前壁切口经耻骨后向下腹部穿刺,将无张力吊带置于尿道中段下方,利用吊带的倒刺结构提起、固定于穿刺经过的耻骨后和各层腹壁组织上,术中膀胱镜监视。结果手术时间平均(30±15)min;术中出血量平均(20±10)ml;术后平均留置导尿管2d;术后平均住院3d。随访1～39个月,平均21个月,尿失禁症状完全消失25例,明显改善3例,无手术失败病例。结论TVT手术治愈率高,操作简便,损伤小,恢复快,并发症发生率低,是一种治疗女性压力性尿失禁的有效方法。     

自体骨髓移植治疗股骨头无菌性坏死

Objective To investigate the effectiveness and mechanism of transplantation of autol-ogous bone marrow in treating femoral head necrosis. Methods Sixty New Zealand rabbits were randomly divided into groups A,B,and C after establishment of the models of femoral head necrosis. The left femoral head served as the control one,and the right as the experimental group. The mitoxantrone (0.1 mg/kg) with the help of DSA was injected into the femoral head of group A. One ml autologous bone marrow was injected into the femoral head of group B. In group C,mitoxantrone (0. 1 mg/kg) was injected,and 72 h later,1 ml autologous bone marrow was injected. Four months later,all rabbits were killed,and the femoral heads were removed and observed histologically and electron microscopically. Results The number of necrotic osteoclasts in groups A and B showed no significant difference ( P > 0.05 ), ande in group C, the number of necrotic femoral heads at the left and fight sides was 40. 60±4.11 and 21.33±2.16 respec-tively ( P < 0.05 ). At the experimental side of group C, the structure of majority bone cells was clear and intact,and necrosis was occasionally seen. Conclusion At the cellular level, local chemotherapy and au-tologous hematopoietic stem cell transplantation had certain effectiveness for aseptic necrosis of the femoral head.     

自体骨髓移植治疗股骨头无菌性坏死

Objective To investigate the effectiveness and mechanism of transplantation of autol-ogous bone marrow in treating femoral head necrosis. Methods Sixty New Zealand rabbits were randomly divided into groups A,B,and C after establishment of the models of femoral head necrosis. The left femoral head served as the control one,and the right as the experimental group. The mitoxantrone (0.1 mg/kg) with the help of DSA was injected into the femoral head of group A. One ml autologous bone marrow was injected into the femoral head of group B. In group C,mitoxantrone (0. 1 mg/kg) was injected,and 72 h later,1 ml autologous bone marrow was injected. Four months later,all rabbits were killed,and the femoral heads were removed and observed histologically and electron microscopically. Results The number of necrotic osteoclasts in groups A and B showed no significant difference ( P > 0.05 ), ande in group C, the number of necrotic femoral heads at the left and fight sides was 40. 60±4.11 and 21.33±2.16 respec-tively ( P < 0.05 ). At the experimental side of group C, the structure of majority bone cells was clear and intact,and necrosis was occasionally seen. Conclusion At the cellular level, local chemotherapy and au-tologous hematopoietic stem cell transplantation had certain effectiveness for aseptic necrosis of the femoral head.     

急性痛风性膝关节炎的临床特点

痛风是常见疾病，但急性痛风性膝关节炎常伴大量关节积液，急性发作期血浆尿酸水平基本正常，在临床上极易与急性化脓性膝关节炎混淆。我院自1990年至2001年共收治22例，其中门诊初步诊断急性化脓性关节炎13例，滑膜炎4例，股骨下段骨髓炎1例。总结如下。     

腰椎间盘突出症的手术治疗（附93例临床分析）

腰椎间盘突出症的手术治疗（附９３例临床分析）高林山，陆建猛，郑建波我院自１９９１年８月至１９９５年８月共收治腰椎间盘突出症９３例，术后效果良好，报告如下。临床资料１．一般资料：本组男性６８例，女性２５例，年龄１９～６８岁。经手术证实椎间盘突出于Ｌ４、...     

颈部阻滞治疗颈椎旁交感节后纤维卡压所致头痛

作者在1996～1999年间用颈部阻滞治疗周围神经卡压症所致颈肩痛、上肢麻木病人时,有24例同时有较重头痛,经阻滞治疗,头痛消失,效果较好。初步考虑系颈椎椎旁肌痉挛卡压交感神经节后纤维所致头痛。总结如下。     

自体骨髓移植治疗股骨头无菌性坏死

Objective To investigate the effectiveness and mechanism of transplantation of autol-ogous bone marrow in treating femoral head necrosis. Methods Sixty New Zealand rabbits were randomly divided into groups A,B,and C after establishment of the models of femoral head necrosis. The left femoral head served as the control one,and the right as the experimental group. The mitoxantrone (0.1 mg/kg) with the help of DSA was injected into the femoral head of group A. One ml autologous bone marrow was injected into the femoral head of group B. In group C,mitoxantrone (0. 1 mg/kg) was injected,and 72 h later,1 ml autologous bone marrow was injected. Four months later,all rabbits were killed,and the femoral heads were removed and observed histologically and electron microscopically. Results The number of necrotic osteoclasts in groups A and B showed no significant difference ( P > 0.05 ), ande in group C, the number of necrotic femoral heads at the left and fight sides was 40. 60±4.11 and 21.33±2.16 respec-tively ( P < 0.05 ). At the experimental side of group C, the structure of majority bone cells was clear and intact,and necrosis was occasionally seen. Conclusion At the cellular level, local chemotherapy and au-tologous hematopoietic stem cell transplantation had certain effectiveness for aseptic necrosis of the femoral head.     

扶正化瘀胶囊联合富马酸丙酚替诺福韦治疗慢性乙肝肝纤维化疗效观察

目的 探讨观察扶正化瘀胶囊联合富马酸丙酚替诺福韦治疗慢性乙肝肝纤维化的疗效及对患者免疫功能和炎症状态的影响.方法 选取2020年3月至2021年3月衢州市人民医院收治的慢性乙肝肝纤维化患者150例,采用随机数字表法分为观察组75例与对照组75例.对照组患者给予富马酸丙酚替诺福韦治疗,观察组在对照组基础上联合扶正化瘀胶囊...