ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION

This study explores a novel noninvasivc method for monitoring blood alfentanil concentrations using a dog model. Alfentanil which “back“ permeated across the oral muccssa from the systemic circulation was collvcted from the oral mugosal surface and quantitated. The levels of the “back“ permeated affentanil were found to closely reflect real time serum affentanfl concentrati~. With Rurther work, this finding may lead to a novel noninvasive method for mollitoring real time serum alfentanil concentrations in its clinical applications.     

海轮碱Ⅱ和汉肌松分别施行控制性降压时的血流动力学效应

在麻醉犬体内分别应用海轮碱Ⅱ和汉肌松施行控制性降压,同时采用Swan-Ganz漂浮导管温度稀释法观察降压期间的血流动力学效应。结果表明海轮减Ⅱ和汉肌松均有显著的降压效应,起效较快,作用时间较短,可控性较好,对心血管系统抑制轻微,有希望成为较理想的控制性降压药。