运用彩色多普勒流速剖面图测定血流量的实验研究

运用实验血流模型，检测新近开发的彩色多普勒血流速度部面图（velocityprofile，VP）对血流量测定的准确性，并与脉冲型多普勒（PulsedwaveDoppler，PWD）测定法比较。结果显示在不同流速下两种方法的流量测值与实际流量间均有高度相关性，相关系数r分别为0．999（P＜0．001）和0．988（P<0．02）。但测得流量与实际流量之间的误差程度，VP法为-7.64～2．79％，PWD法为17.82～27.97％。表明VP法较PWD法更接近实际情况。     

超声造影评价肝脏转移瘤血供的价值:增强CT的对比研究

目的 CEUS和CECT评价肝脏转移瘤血供情况了解CEUS在评价肝脏转移瘤血供方面有无优势.方法 61例患者入组研究,同时行CEUS和CECT检查.结果 CEUS动脉期61个病灶最高增强水平表现为高、等、低、无增强的例数分别为54(88.5%)、6(9.8%)、1(1.7%)和0,而CECT的例数分别为47(77.0%)、6(9.8%)、7(1 1.5%)和1(1.7%).CEUS动脉期表现为全瘤均匀、不均匀及环状增强的例数分别为26(42.6%)、13(21.3%)、22(36.1%).而CECT的例数分别为8(13.1%)、8(13.1%)、45(73.8%).CEUS检}{|供瘤血管29例(47.5%),CECT有21例(34.4%)可观察到瘤周血管.CEUS检出富血供肿瘤68.9%,乏血供肿瘤31.1%;CECT检出富血供肿瘤16.4%,乏血供肿瘤83.6%,两者之间的差异有统计学意义(P相似文献   

肝细胞癌的分子靶向治疗进展

肝细胞癌(Hepatocellular carcinoma,HCC)是世界范围内最常见的恶性肿瘤之一,其死亡率高居恶性肿瘤的第三位。由于大多数HCC患者就诊时疾病已处于中晚期,单纯依靠手术切除、经肝动脉栓塞化疗、射频/微波消融等传统治疗手段往往难以取得满意的疗效。近年来,针对恶性肿瘤发生发展过程     

肝切除在肝胆管结石治疗中的作用及地位

肝胆管结石是指发生于左右肝管汇合之上的肝内胆管结石,可累及肝脏某一个或多个相邻肝段、肝叶、甚至全肝,通常合并存在胆管狭窄、汇合异常或胆管囊状扩张,是一种治疗困难的良性疾病,尤其是对一些复杂的肝胆管结石者。虽然高位胆管切开取石已被广泛应用于肝胆管结石的治疗,但往往难以取净结石,且术后结石复发率高。规则性肝段、肝叶切除有助于取净结石、同时一并去除病变的胆管及肝组织,具有结石残留率低、复发率低的突出优势,提高手术治疗效果。因此,肝切除是肝胆管结石最为彻底的治疗方式,对有适应证的病人应积极采用规则性肝段、肝叶切除术。     

达芬奇机器人在胆总管囊肿手术切除中的应用

目的评估达芬奇机器人手术系统辅助胆总管囊肿切除术的安全性及疗效,总结手术经验。 方法回顾性分析2016年3月至2018年12月于中山大学附属第一医院胆胰外科接受达芬奇机器人辅助胆总管囊肿切除术的12例患者临床资料,分析其相关的临床数据,评估手术的安全性及近期疗效。 结果12例均顺利完成机器人辅助下胆总管囊肿及胆囊切除、肝管空肠改良襻式吻合术;手术中位时间为385 min（280~420 min）,术中出血量中位数为30 ml（30~100 ml）。3例有腹腔手术史患者术后进食时间、住院时间与无手术史的患者比较,差异无统计学意义。术后1例患者发生腹腔感染,经保守治疗后痊愈;术后平均住院（7.7±1.4）d,无一例30 d内再入院。 结论达芬奇机器人辅助胆总管囊肿切除手术安全、可靠,操作更精准灵活、舒适,具有微创、术中出血少、术后恢复快的优势。     

术前胆道引流对肝门部胆管癌手术并发症的影响

但不能降低术后并发症发生率和住院病死率.Bismuth-Corlette分型、是否合并肝切除是预测患者术后风险的重要因素.     

ABCG2蛋白在肝癌中表达的临床意义

Objective To investigate the expression and clinical significance of ABCG2 protein in hepato-cellular carcinoma (HCC). Methods Specimens of HCC were collected at The First Aifiliated Hospital of Sun Yat-sen University from January 2005 to December 2006. The expression of ABCG2 protein in 165 samples of HCC tissue, 25 samples of normal liver tissue and 40 samples of cirrhotic liver tissue was detected using immunohisto-chemistry. The correlation between the expression of ABCG2 protein and clinicopathological characters was then analyzed. Enumeration data, survival rate and the difference between groups were analyzed with a chi-square test, the Kaplan-Meier method and Log-rank test, respectively. Results ABCG2 protein expression was weakly posi-tive in all normal and cirrhotic liver tissues. In HCC tissues, the expression of ABCG2 protein was strongly positive in 66 cases and weakly positive in 99 cases. The expression of ABCG2 protein was related to tumor diameter, tumor number, adjacent organ invasion and TNM stages (χ2 =8. 130, 14. 279, 4. 820, 21. 179, P <0. 05). Kaplan-Meier survival analysis revealed that patients with strongly positive ABCG2 protein had a significantly lower 3-year overall survival (24. 1%) compared with those with weakly positive ABCG2 protein (39. 4%) (χ2 = 15.716, P<0.05). Conclusions The expression level of ABCG2 protein is related to tumor invasiveness, TNM stage and prognosis. ABCG2 has the potential to become a new target for HCC treatment.     

前入路右半肝切除术与传统右半肝切除术治疗大肝癌的对比观察

Objective To compare the outcomes between anterior versus conventional approach right hepatectomy for large hepatocellutar carcinoma(HCC).Methods A total of 188 consecutive patients with large HCC(≥5 cm)undergoing right hepatectomy were reviewed retrospectively.Among them,92patients received anterior approach right hepatectomy(anterior group)while the other conventional right hepatectomy(conventional group).Their clinicopathologic data and survivals were compared.Results There were five surgical deaths(2.7%),two in the anterior group and three in the conventional group.The biochemical and tumor pathological data(except for tumor size) of these two groups were comparable.The mean intranperative blood loss,the number of patients with massive hemorrhage(＞3000ml)and the volume of blood transfusion of the anterior group were markedly less than those of conventional group.The 1-,3-year disease-free survival rates of the anterior group were significantly better than those of the conventional group anterior group were also markedly higher than those of conventional group.The Cox regression model indicated that tumor size[P=0.014,odd ratio(OD):1.074] and surgical procedure(P:0.009,OD=0.468) were independent risk factors correlated with disease-free survival.And the surgical procedure(P=0.003,OD=0.369) was the only independent risk factor for postoperative cumulative survival.Conclusion Anterior approach right hepatectomy can significantly decrease intraoperative blood loss.The postoperative survivals of large HCC patients are significantly improved by anterior approach right hepatectomy.