儿童紫癜性肾炎的危险因素研究

目的分析儿童过敏性紫癜(HSP)的发病率与肾脏损害的危险因素。方法将2008年1月～2010年5月入住河南科技大学第一附属医院的110例HSP患儿,分为紫癜性肾炎(HSPN)组和非肾炎组,对性别、年龄、季节、居住环境、临床表现及实验室检验等因素进行单因素和多因素分析,单因素用2检验,多因素用Logstic回归分析(P<0.05)。结果①HSP中72例出现肾脏损害,发病率为65.5%,94.4%HSPN患儿尿检异常发生在起病1个月内,且在2周内的有63例(87.5%)。②经单变量分析,皮疹持续时间及皮疹3月内反复≥3次、消化道出血、年龄>7岁、腹痛与HSPN发生密切相关(P<0.05)。经逐步Logstic回归分析示,年龄>7岁与HSPN发生密切相关(P<0.05)。结论 HSP患儿中年龄>7岁,易出现肾脏受累,应严密监测并采取积极的治疗措施以防止肾脏损害的发生和进展。     

大豆异黄酮在不同的雌激素环境下对MMTV-erbB-2转基因小鼠的作用

目的 观察大豆异黄酮在不同的雌激素环境下,对MMTV-erbB-2转基因小鼠的乳腺肿瘤发生及发展的影响.方法 选取鼠龄5周的健康MMTV-erbB-2转基因雌性小鼠150只,分为对照组、低雌激素组1、低雌激素组2、高雌激素组1和高雌激素组2五组,观察各组小鼠乳腺癌的发病率和潜伏期,并采用免疫组织化学染色SP法检测各组小鼠乳腺组织中雌激素受体(ER)、孕激素受体(PR)、增殖细胞核抗原(PCNA)的表达.结果 对照组、低雌激素组1、低雌激素组2、高雌激素组1和高雌激素组2的乳腺癌发病率分别为73.3%、96.7%、30.3%、40.0%和83.3%,对照组与高雌激素组2、低雌激素组1与高雌激素组2发病率比较差异无统计学意义(P＞0.05),其他各组间比较差异有统计学意义(P＜0.05).各组小鼠乳腺癌平均潜伏期比较差异无统计学意义(P＞0.05).低雌激素组1的TEB数量与其他各组比较差异有统计学意义(P＜0.05).erbB-2表达在各组之间表达差异无统计学意义(P＞0.05).低雌激素组1、低雌激素组2、高雌激素组1和高雌激素组2与对照组乳腺ER和PR的表达比较差异无统计学意义(P＞0.05).低雌激素组1实验小鼠发生肿瘤的乳腺组织内PCNA的表达明显高于其他各组(P＜0.05).对照组与高雌激素组2,低雌激素组1与高雌激素组2比较差异有统计学意义(P＜0.05),其他各组间比较差异有统计学意义(P＜0.05).结论 大豆异黄酮在不同的雌激素环境下,对MMTV-erbB-2转基因小鼠乳腺肿瘤的发生及发展起不同的作用.低雌激素环境下大豆异黄酮可促进乳腺肿瘤的发生及发展,高雌激素环境下大豆异黄酮可抑制乳腺肿瘤的发生及发展.

Abstract：

Objective To investigate the effect of the soybean isoflavones at different estrogen environments on the pathogenesis of breast cancer in MMTV-erbB-2 transgenic mice. Methods 150 fiveweek-old MMTV-erbB-2 transgenic female mice were phosen and divided into five groups; control group,low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2. The incidence and latent period of breast cancer were observed, and the expression of estrogen receptor (ER) ,progesterone receptor (PR), and proliferating cell nuclear antigen (PCNA) proteins was detected by using immunohistochemistry SP method. Results The incidence of breast cancer in control group, low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2 was 73. 3% , 96. 7% ,30. 3% , 40. 0% and 83. 3% , respectively, with the difference being not significant between control group and high estrogen group 2, and between low estrogen group 1 and high estrogen group 2 (P ＞ 0. 05 ) , but with the difference being significant among the other groups (P ＜ 0. 05 ). There was significant difference in the average latent period of breast cancer among all groups (P ＞ 0. 05 ). There was significant difference in the number of TEB between low-estrogen group 1 and other groups (P ＜ 0.05). There was significant difference in the erbB-2 expression among the groups ( P ＞ 0. 05 ). There was no significant difference in the expression of breast ER and PR between control group and other groups ( P ＞ 0. 05 ). The PCNA expression in breast tumor tissue in low-estrogen group 1 was significantly higher than other groups (P ＜0. 05) , and there was significant difference in the PCNA expression between control group and high estrogen group 2, between low estrogen group 1 and high estrogen group 2 (P ＜ 0. 05). Conclusion The soybean isoflavones at different estrogen environments play different roles in the occurrence and development of MMTV-erbb-2 transgenic mouse mammary tumor. In the context of low estrogen, soybean isoflavones could even promote breast cancer formation and development. In the context of high estrogen, soybean isoflavones could inhibit breast cancer and development.     

更换引流袋对脑室引流患者的影响

目的 探讨引流袋更换频率对开颅术后脑室引流患者的影响,以预防潜在的并发症.方法 将颅脑术后安置脑室引流管的62例患者随机分为对照组和观察组,每组各31名.对照组使用常规护理方法即每日更换引流袋,观察组则在引流管未堵塞的情况下不每日进行更换.比较2组平均拔管时间及10d内并发症的发生率.结果 2组患者拔管时间和并发症发生率无明显差异（P〉0.05）.结论 在未发生堵管的情况下,引流袋不必每日进行更换,此法经济方便,可减轻患者经济负担和护理人员工作量.     

大豆异黄酮在低雌激素环境下对MMTV-erbB-2转基因小鼠的作用

目的探讨大豆异黄酮在低雌激素环境下对MMTV-erbB-2转基因小鼠乳腺肿瘤发生、发展的影响。方法 MMTV-erbB-2转基因雌性小鼠90只,分为3组,每组30只。60只行卵巢摘除术使MMTV-erbB-2转基因小鼠体内形成低雌激素环境,分别使用含大豆异黄酮饲料(大豆异黄酮组)和普通饲料(普通饲料组)喂养。另30只为对照组,用普通饲料喂养。观察乳腺肿瘤的潜伏期及发生情况,用免疫组织化学法观察各组乳腺组织的雌激素受体、孕激素受体、增殖细胞核抗原的表达情况。结果大豆异黄酮组肿瘤潜伏期较其他2组明显缩短,增殖细胞核抗原表达水平较其他2组高(P<0.05)。3组雌激素受体、孕激素受体表达情况比较差异无统计学意义(P>0.05)。结论在低雌激素环境下,大豆异黄酮对MMTV-erbB-2转基因小鼠乳腺肿瘤的发生、发展起促进作用。     

太原市生活垃圾卫生填埋场工程设计研究报告

太原市是一个大型重工业城市,现有城巿人口约150万。日产生活垃圾2 400t/d。随着我市经济的发展和人民生活水平的提高,城市生活垃圾的产量不断增加,垃圾成份越来越复杂,其污染性也越来越强,对生活垃圾无害化处理的要求也越来越高。目前,国内外生活垃圾无害化处理主要采取卫生填埋的方式。垃圾填埋场的环境效益如何,直接反映一     

城市建筑垃圾分类及治理研究

分析了城市建筑垃圾的特征、特性,探讨建筑垃圾来源分类法、物理成分分类法和可利用性分类法及其在建筑垃圾管理、对策研究中的作用;提出建筑垃圾治理属于“公共治理”范畴的观点;须遵循系统规则,并有系统框架和技术支持才能达到治理目的.     

大豆异黄酮在不同的雌激素环境下对MMTV-erbB-2转基因小鼠的作用

Objective To investigate the effect of the soybean isoflavones at different estrogen environments on the pathogenesis of breast cancer in MMTV-erbB-2 transgenic mice. Methods 150 fiveweek-old MMTV-erbB-2 transgenic female mice were phosen and divided into five groups; control group,low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2. The incidence and latent period of breast cancer were observed, and the expression of estrogen receptor (ER) ,progesterone receptor (PR), and proliferating cell nuclear antigen (PCNA) proteins was detected by using immunohistochemistry SP method. Results The incidence of breast cancer in control group, low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2 was 73. 3% , 96. 7% ,30. 3% , 40. 0% and 83. 3% , respectively, with the difference being not significant between control group and high estrogen group 2, and between low estrogen group 1 and high estrogen group 2 (P ＞ 0. 05 ) , but with the difference being significant among the other groups (P ＜ 0. 05 ). There was significant difference in the average latent period of breast cancer among all groups (P ＞ 0. 05 ). There was significant difference in the number of TEB between low-estrogen group 1 and other groups (P ＜ 0.05). There was significant difference in the erbB-2 expression among the groups ( P ＞ 0. 05 ). There was no significant difference in the expression of breast ER and PR between control group and other groups ( P ＞ 0. 05 ). The PCNA expression in breast tumor tissue in low-estrogen group 1 was significantly higher than other groups (P ＜0. 05) , and there was significant difference in the PCNA expression between control group and high estrogen group 2, between low estrogen group 1 and high estrogen group 2 (P ＜ 0. 05). Conclusion The soybean isoflavones at different estrogen environments play different roles in the occurrence and development of MMTV-erbb-2 transgenic mouse mammary tumor. In the context of low estrogen, soybean isoflavones could even promote breast cancer formation and development. In the context of high estrogen, soybean isoflavones could inhibit breast cancer and development.     

大豆异黄酮在不同的雌激素环境下对MMTV-erbB-2转基因小鼠的作用

Objective To investigate the effect of the soybean isoflavones at different estrogen environments on the pathogenesis of breast cancer in MMTV-erbB-2 transgenic mice. Methods 150 fiveweek-old MMTV-erbB-2 transgenic female mice were phosen and divided into five groups; control group,low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2. The incidence and latent period of breast cancer were observed, and the expression of estrogen receptor (ER) ,progesterone receptor (PR), and proliferating cell nuclear antigen (PCNA) proteins was detected by using immunohistochemistry SP method. Results The incidence of breast cancer in control group, low estrogen group 1, low estrogen group 2, high estrogen group 1 and high estrogen group 2 was 73. 3% , 96. 7% ,30. 3% , 40. 0% and 83. 3% , respectively, with the difference being not significant between control group and high estrogen group 2, and between low estrogen group 1 and high estrogen group 2 (P ＞ 0. 05 ) , but with the difference being significant among the other groups (P ＜ 0. 05 ). There was significant difference in the average latent period of breast cancer among all groups (P ＞ 0. 05 ). There was significant difference in the number of TEB between low-estrogen group 1 and other groups (P ＜ 0.05). There was significant difference in the erbB-2 expression among the groups ( P ＞ 0. 05 ). There was no significant difference in the expression of breast ER and PR between control group and other groups ( P ＞ 0. 05 ). The PCNA expression in breast tumor tissue in low-estrogen group 1 was significantly higher than other groups (P ＜0. 05) , and there was significant difference in the PCNA expression between control group and high estrogen group 2, between low estrogen group 1 and high estrogen group 2 (P ＜ 0. 05). Conclusion The soybean isoflavones at different estrogen environments play different roles in the occurrence and development of MMTV-erbb-2 transgenic mouse mammary tumor. In the context of low estrogen, soybean isoflavones could even promote breast cancer formation and development. In the context of high estrogen, soybean isoflavones could inhibit breast cancer and development.     

太原生活垃圾填埋渗沥液监测、处理的研究报告

生活垃圾渗沥液是一种高浓度、污染性很强的液体.通过对太原市河西南寨生活垃圾填埋场的渗沥液进行监测分析,指出控制有机垃圾的填埋量,搞好渗沥液的收集处理,是减少环境污染的必要手段.     

太原市特种垃圾现状调查报告

通过对太原市特种垃圾的产量、物理成分、处理现状及产源地分布等因素的调查,得出太原市特种垃圾产量大、成分复杂、无害化处理水平低的结论,说明太原市实行特种垃圾的统一收集、集中焚烧是十分必要的.