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排序方式: 共有512条查询结果,搜索用时 46 毫秒
1.
Marta Revilla-León Adriana Besné-Torre Jose Luis Sánchez-Rubio Javier J. Fábrega Mutlu Özcan 《The Journal of prosthetic dentistry》2019,121(1):3-8
The development of technologies including intraoral scanners, dental software for digital restoration design, and additive manufacturing has improved the digital workflow of restorative treatment. The present article describes a digital workflow with intraoral scanning, computer-aided design (CAD) software, and subtractive and additive manufacturing procedures for a patient receiving lithium disilicate laminate veneers. 相似文献
2.
This study evaluated the influence of different thermal (TC) and mechanical (MC) cycling protocols on microtensile bond strength (muTBS) to cervical dentin margins of Class II restorations using two total-etch (TE) adhesives and one self-etching (SE) primer. Class II slot cavities were prepared on the mesial surfaces of 168 bovine incisors and were divided into three groups according to the bonding system used: Single Bond, OptiBond Solo Plus and Clearfil SE Bond. All cavities were restored with Filtek Z250 composite. Following restorative procedures, the restored teeth were allocated to seven subgroups (n = 8) according to the thermal/mechanical protocol performed: G1-control (no cycling), G2-100,000 MC, G3-200,000 MC, G4-500,000 MC, G5-100,000 MC+1,000 TC, G6-200,000 MC+1,000 TC, G7-500,000 MC+1,000 TC. TC was performed using 5 +/- 2 degrees C and 55 +/- 2 degrees C baths, with a dwell time of 60 seconds in each bath. MC was achieved with an axial force of 80 N at 2 cycles/second. The restorations were sectioned perpendicular to the cervical bonded interface into two 0.8-1-mm thick slabs. The slabs were trimmed at the interface to obtain a cross-sectional surface area of 0.8-1 mm2. All specimens were then subjected to muTBS (v = 0.5 mm/minute). Fracture mode analysis was performed using SEM. Bond strength mean values (MPa) were analyzed with ANOVA 3-way and Tukey's test (alpha = 5%). Dunnett's test was used to compare tested groups against Control groups of each adhesive system (alpha = 56%). SE primer presented lower mean bond strength values when compared to TE adhesives (p = 0.05). In addition, specimens restored with the SE primer did not resist to the 200,000 and 500,000 MC associated with TC. The application of 100,000 MC did not present a significant decrease in bond strength when compared to the control. Mixed failures were predominant for all groups. The higher the amount of thermal/mechanical cycles, the greater the number of mixed failures and the lower the percentage of adhesive failures. 相似文献
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Bradley P. Weegman Thomas M. Suszynski William E. Scott III Joana Ferrer Fábrega Efstathios S. Avgoustiniatos Takayuki Anazawa Timothy D. O'Brien Michael D. Rizzari Theodore Karatzas Tun Jie David E. R. Sutherland Bernhard J. Hering Klearchos K. Papas 《Xenotransplantation》2014,21(6):574-581
Porcine islet xenotransplantation is a promising alternative to human islet allotransplantation. Porcine pancreas cooling needs to be optimized to reduce the warm ischemia time (WIT) following donation after cardiac death, which is associated with poorer islet isolation outcomes. This study examines the effect of four different cooling Methods on core porcine pancreas temperature (n = 24) and histopathology (n = 16). All Methods involved surface cooling with crushed ice and chilled irrigation. Method A, which is the standard for porcine pancreas procurement, used only surface cooling. Method B involved an intravascular flush with cold solution through the pancreas arterial system. Method C involved an intraductal infusion with cold solution through the major pancreatic duct, and Method D combined all three cooling Methods. Surface cooling alone (Method A) gradually decreased core pancreas temperature to <10 °C after 30 min. Using an intravascular flush (Method B) improved cooling during the entire duration of procurement, but incorporating an intraductal infusion (Method C) rapidly reduced core temperature 15–20 °C within the first 2 min of cooling. Combining all methods (Method D) was the most effective at rapidly reducing temperature and providing sustained cooling throughout the duration of procurement, although the recorded WIT was not different between Methods (P = 0.36). Histological scores were different between the cooling Methods (P = 0.02) and the worst with Method A. There were differences in histological scores between Methods A and C (P = 0.02) and Methods A and D (P = 0.02), but not between Methods C and D (P = 0.95), which may highlight the importance of early cooling using an intraductal infusion. In conclusion, surface cooling alone cannot rapidly cool large (porcine or human) pancreata. Additional cooling with an intravascular flush and intraductal infusion results in improved core porcine pancreas temperature profiles during procurement and histopathology scores. These data may also have implications on human pancreas procurement as use of an intraductal infusion is not common practice. 相似文献
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6.
K.M. Santiago L.P. Castro J.P.D. Neto A.F. de Nóbrega C.A.L. Pinto P. Ashton-Prolla F. Pinto e Vairo P.F.V. de Medeiros E.M. Ribeiro B.F.R. Ribeiro F.F. do Valle M.J.R. Doriqui C.H.B. Leite R.M. Rocha L.M.S. Moura V. Munford P.A.F. Galante C.F.M. Menck S.R. Rogatto M.I. Achatz 《Journal of the European Academy of Dermatology and Venereology》2020,34(10):2392-2401
7.
Marcelo Tavares de Oliveira André Figueiredo Reis Cesar Augusto Galvão Arrais Andrea Nóbrega Cavalcanti Ana Cecília Corrêa Aranha Carlos de Paula Eduardo Marcelo Giannini 《Lasers in medical science》2013,28(4):1069-1076
This study evaluated the effects of different parameters of dentin irradiation with erbium-doped yttrium aluminum garnet (Er:YAG) laser on bond strength to dentin and analyzed the ultramorphological characteristics of resin–laser-irradiated dentin interfaces using a transmission electron microscope (TEM). Dentin surfaces were abraded with SiC paper (600 grit) or Er:YAG laser-irradiated (120/4, 140/6, 180/4, or 200/6 mJ/Hz). Three adhesive systems were tested: Single Bond Plus (3M ESPE), Clearfil Protect Bond (Kuraray Med.), and Clearfil Tri-S Bond (Kuraray Med.). Treatments were performed over flat dentin surfaces of human third molars. Specimens were stored in distilled water for 1 week or 6 months and prepared for a microtensile bond strength test and interfacial ultrastructure for analysis. Microtensile bond strength data (n?=?5) were analyzed with three-way analysis of variance. Irradiation with Er:YAG laser did not reduce the bond strength values for self-etching adhesives even after 6 months of water storage. The hybrid layer formation was observed only when the adhesives were applied to non-irradiated dentin (control group). Nanoleakage occurred in all resin–dentin interfaces using Single Bond Plus for both periods. Nanoleakage pattern and bond strength of self-etching adhesives to dentin were less affected by Er:YAG laser irradiation and by the 6-month storage in water than was those of the etch-and-rinse adhesive. TEM analysis revealed no hybridization when dentin was laser-irradiated. Clinical significance: Minimally invasive caries removal has been proposed. Nevertheless, bonding mechanisms to lased dentin are not entirely described. Knowing the interaction between the treated dentin and bonding agents and its behavior over time is of utmost importance for new technologies. Regarding that, two-bottle self-etching adhesive system provided a more consistent evidence of its better behavior when bonding to lased substrate. 相似文献
8.
Moraes CF Souza ER Souza VC Medeiros EF Gonçalves TF Toledo JO Karnikowski M Gomes L Karnikowski MG Córdova C Nóbrega OT 《Clinica chimica acta; international journal of clinical chemistry》2008,396(1-2):70-75
BACKGROUND: Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy. METHODS: This prospective study involved 169 hypertensive, community-dwelling older women. Genotypes were obtained by length analysis or direct sequencing of PCR products. Blood pressure-lowering pharmacotherapy was conducted according to current Brazilian Guidelines on Hypertension. RESULTS: Genotype frequencies were in agreement to the Hardy-Weinberg equilibrium. Interventions were found to represent actual hypertension-management practices in Brazil, and accounted for a significant reduction in both systolic (P<0.001) and diastolic (P<0.001) blood pressure. Concerning the effect of polymorphisms, no influence of the ACE and AT1R genotypes were found on the magnitude of the treatment-induced blood pressure reduction (P>0.05). Nonetheless, the clinical result varied according to the ACE alleles since mean systolic pressure was roughly 10 mm Hg higher in insertion (I) homozygotes than in the deletion (D) counterparts either in baseline (P=0.001) and endpoint (P=0.010). CONCLUSION: The outcome of the antihypertensive pharmacotherapy advocated by national guidelines was significantly influenced by the ACE I/D polymorphism but not by the AT1R 1166 A/C polymorphism among postmenopausal women. 相似文献
9.
De Moraes R Gioseffi G Lopes Ndo N Gomes MB Nóbrega AC Tibiriçá E 《Fundamental & clinical pharmacology》2005,19(5):537-543
It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non-diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12-week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs-Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d-glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose-related vasodilator responses, reaching the maximum of 41+/- 2% (n=10; P<0.05). In the kidneys perfused with high concentrations of glucose (SED 15), endothelium-dependent vasodilation was significantly blunted. Maximal relaxation in the presence of 15 mm glucose was of 19 +/- 2%, which was significantly different from the SED 5.5 group (41+/- 2%, n=10, P<0.01). In the ExT 5.5 group, ACh-induced vasodilation was significantly enhanced when compared with the SED 5.5 group, reaching the maximum of (52+/- 2%, n=10, P<0.05). Moreover, the exposure of the renal circulation of ExT animals to high glucose did not change endothelium-dependent vasodilation induced by ACh (46+/- 3%, n=6), when compared with the ExT 5.5 group. Finally, exercise training prevented the deleterious effects of high glucose on endothelial-dependent renal vasodilation (SED 15: 19+/- 2% vs. ExT 15: 46+/- 3%; P<0.05). It is concluded that exercise training protects the rabbit renal circulation against endothelial dysfunction elicited by acute exposure to moderately elevated glucose levels, corresponding to the postprandial glycemia of diabetes type 2 patients under treatment. The enhanced renal vasodilator reserve elicited by exercise training turns out to be a response that protects the kidney from the deleterious effects of glycemic peaks. 相似文献
10.
Sabrina Lindemberg Sergio Chermont M?nica Quint?o Milena Derossi Sergio Guilhon Sabrina Bernardez Luana Marchese Wolney Martins Ant?nio Claudio L. Nóbrega Evandro Tinoco Mesquita 《Arquivos brasileiros de cardiologia》2014,102(3):279-287