全文获取类型
收费全文 | 291篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 3篇 |
基础医学 | 37篇 |
口腔科学 | 76篇 |
临床医学 | 21篇 |
内科学 | 41篇 |
皮肤病学 | 8篇 |
神经病学 | 17篇 |
外国民族医学 | 1篇 |
外科学 | 67篇 |
综合类 | 1篇 |
预防医学 | 19篇 |
眼科学 | 1篇 |
药学 | 4篇 |
肿瘤学 | 3篇 |
出版年
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2013年 | 4篇 |
2012年 | 7篇 |
2011年 | 11篇 |
2010年 | 3篇 |
2009年 | 9篇 |
2008年 | 10篇 |
2007年 | 14篇 |
2006年 | 7篇 |
2005年 | 10篇 |
2004年 | 10篇 |
2003年 | 8篇 |
2002年 | 11篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1997年 | 2篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1987年 | 13篇 |
1986年 | 13篇 |
1985年 | 10篇 |
1984年 | 7篇 |
1983年 | 9篇 |
1982年 | 11篇 |
1981年 | 8篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 9篇 |
1977年 | 7篇 |
1975年 | 7篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 4篇 |
1971年 | 6篇 |
1970年 | 7篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1959年 | 1篇 |
排序方式: 共有301条查询结果,搜索用时 31 毫秒
1.
Polina MARTINKEVICH Lise Langeland LARSEN Troels GRSHOLT-KNUDSEN Gitte HESTHAVEN Michel Bach HELLFRITZSCH Karin Kastberg PETERSEN Bjarne M
LLER-MADSEN Jan Duedal R
LFING 《Acta orthopaedica》2020,91(5):527
Background and purposePhysical abuse of children, i.e., nonaccidental injury (NAI) including abusive head trauma (AHT) is experienced by up to 20% of children; however, only 0.1% are diagnosed. Healthcare professionals issue less than 20% of all reports suspecting NAI to the responsible authorities. Insufficient knowledge concerning NAI may partly explain this low percentage. The risk of NAI is heightened during health and socioeconomic crises such as COVID-19 and thus demands increased awareness. This review provides an overview and educational material on NAI and its clinical presentation.MethodsWe combined a literature review with expert opinions of the senior authors into an educational paper aiming to help clinicians to recognize NAI and act appropriately by referral to multidisciplinary child protection teams and local authorities.ResultsDespite the increased risk of NAI during the current COVID-19 crisis, the number of reports suspecting NAI decreased by 42% during the lockdown of the Danish society. Healthcare professionals filed only 17% of all reports of suspected child abuse in 2016.InterpretationThe key to recognizing and suspecting NAI upon clinical presentation is to be aware of inconsistencies in the medical history and suspicious findings on physical and paraclinical examination. During health and socioeconomic crises the incidence of NAI is likely to peak. Recognition of NAI, adequate handling by referral to child protection teams, and reporting to local authorities are of paramount importance to prevent mortality and physical and mental morbidity.Physical abuse of children, i.e., non-accidental injury (NAI) including abusive head trauma (AHT), is experienced by up to 20% of children; however, only 0.1% are diagnosed with the ICD-10 code: T74.1 physical abuse (Christoffersen 2010, Stoltenborgh et al. 2013, Oldrup et al. 2016).During the current COVID-19 crisis some European countries have reported an alarming increase in domestic violence by one-third (Delaleu 2020). Likewise, the risk of NAI is heightened during health and socioeconomic crises (Baird 2020, Peterman et al. 2020). Therefore, a Joint Leaders’ statement by the World Health Organization, UNICEF, Save the Children International, and SOS Children’s Villages International among others, highlights the acute risk of violence against children due to COVID-19 and calls for increased awareness (World Health Organization 2020).The vast majority of NAI is reported by staff working at institutions (daycares, kindergartens, schools), which are temporarily closed during the COVID-19 pandemic. Healthcare professionals issue less than 20% of reports regarding suspected maltreatment to the responsible child protection authorities (Christoffersen 2010, Oldrup et al. 2016). Failure to recognize NAI due to insufficient knowledge among healthcare professionals may partly explain this low percentage (Villadsen et al. 2015).Healthcare professionals need to be aware of the increased risk of NAI during COVID-19 and future health and socio-economic crises in order to act appropriately based on current knowledge of the issue. Only then can they begin to recognize patterns of NAI from the medical history and objective findings, and act appropriately through immediate consultation and referral to multidisciplinary child protection teams, who can clarify the suspicion and ensure child protection. 相似文献
2.
3.
Bjørn Blomberg Karim P Manji Willy K Urassa Bushir S Tamim Davis SM Mwakagile Roland Jureen Viola Msangi Marit G Tellevik Mona Holberg-Petersen Stig Harthug Samwel Y Maselle Nina Langeland 《BMC infectious diseases》2007,7(1):1-14
Background
Bloodstream infection is a common cause of hospitalization, morbidity and death in children. The impact of antimicrobial resistance and HIV infection on outcome is not firmly established.Methods
We assessed the incidence of bloodstream infection and risk factors for fatal outcome in a prospective cohort study of 1828 consecutive admissions of children aged zero to seven years with signs of systemic infection. Blood was obtained for culture, malaria microscopy, HIV antibody test and, when necessary, HIV PCR. We recorded data on clinical features, underlying diseases, antimicrobial drug use and patients' outcome.Results
The incidence of laboratory-confirmed bloodstream infection was 13.9% (255/1828) of admissions, despite two thirds of the study population having received antimicrobial therapy prior to blood culture. The most frequent isolates were klebsiella, salmonellae, Escherichia coli, enterococci and Staphylococcus aureus. Furthermore, 21.6% had malaria and 16.8% HIV infection. One third (34.9%) of the children with laboratory-confirmed bloodstream infection died. The mortality rate from Gram-negative bloodstream infection (43.5%) was more than double that of malaria (20.2%) and Gram-positive bloodstream infection (16.7%). Significant risk factors for death by logistic regression modeling were inappropriate treatment due to antimicrobial resistance, HIV infection, other underlying infectious diseases, malnutrition and bloodstream infection caused by Enterobacteriaceae, other Gram-negatives and candida.Conclusion
Bloodstream infection was less common than malaria, but caused more deaths. The frequent use of antimicrobials prior to blood culture may have hampered the detection of organisms susceptible to commonly used antimicrobials, including pneumococci, and thus the study probably underestimates the incidence of bloodstream infection. The finding that antimicrobial resistance, HIV-infection and malnutrition predict fatal outcome calls for renewed efforts to curb the further emergence of resistance, improve HIV care and nutrition for children. 相似文献4.
Blomberg B Olsen BE Hinderaker SG Langeland N Gasheka P Jureen R Kvåle G Midtvedt T 《Scandinavian journal of infectious diseases》2005,37(4):262-268
Treatment of asymptomatic bacteriuria and urinary tract infections in pregnancy can prevent adverse outcome for mother and child. However, antimicrobial resistance can impede effective chemotherapy. From April 1995 to March 1996, urine specimens from 5153 pregnant women in a rural area in northern Tanzania were inoculated on dip slides. Bacterial isolates from 101 positive dip slides were identified and tested for susceptibility to antimicrobial agents by disc diffusion. In total, 107 bacterial isolates were recovered, 71 Gram-negative and 36 Gram-positive. The most frequent isolates were Escherichia coli (n=27) and enterococci (n=15). E. coli isolates showed low rates of resistance to ampicillin (17%), mecillinam (9%), cefalexin (0%), nitrofurantoin (4%), trimethoprim-sulfamethoxazole (0%), trimethoprim (13%) and sulfamethoxazole (0%). Other Gram-negative bacteria displayed higher rates of resistance to these drugs. All enterococcal isolates were sensitive to ampicillin and only 2 were resistant to nitrofurantoin. Growth of E. coli from urine culture was correlated with adverse outcome of pregnancy (relative risk 4.13, 95% confidence interval 1.50-11.38). Antimicrobial susceptibility prevails in urinary isolates of E. coli and enterococci from rural areas of northern Tanzania. Susceptibility data from both rural and urban areas should be taken into account when planning antibiotic policies. 相似文献
5.
6.
Experimental assessment of a new research tool for the estimation of two-dimensional myocardial strain 总被引:5,自引:0,他引:5
Langeland S Wouters PF Claus P Leather HA Bijnens B Sutherland GR Rademakers FE D'hooge J 《Ultrasound in medicine & biology》2006,32(10):1509-1513
One-dimensional strain imaging has been shown to be angle dependent. To address this problem, a new methodology, 2D-strain, has become available. The aim of this study was to validate this methodology in an in vivo set-up against sonomicrometry. In five open chest sheep, ultrasound gray-scale images were acquired of the inferolateral wall from two different angles. The longitudinal and radial strain components were simultaneously extracted using the novel 2D-strain methodology. The extracted values were compared with sonomicrometry using Bland-Altman statistics and correlation coefficients. A good agreement was found for the longitudinal strain component, while, for the radial strain estimates, the accuracy was less. 2D-strain is a fast and accurate tool to assess longitudinal strain from apical views. Further improvements are needed for the method to be sufficiently accurate in estimating the deformation perpendicular or close to perpendicular to the ultrasound beam. 相似文献
7.
Voltersvik P Halstensen A Langeland N Digranes A Peterson LE Rolstad T Solberg CO 《The Journal of antimicrobial chemotherapy》2000,46(3):457-459
Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains. 相似文献
8.
9.
Bone changes after castration in rats. A model for osteoporosis 总被引:3,自引:0,他引:3
L Gürkan A Ekeland K M Gautvik N Langeland H R?nningen L F Solheim 《Acta orthopaedica Scandinavica》1986,57(1):67-70
Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters. No influence of castration on the mechanical strength of the femora could be detected in either sex. At 2 weeks after castration, the circulating levels of immunoreactive calcitonin (iCT) were decreased in female rats compared to controls. In contrast, iCT was increased both in castrated male and female rats 10 weeks later. We conclude that castration of 6-month-old female rats causes osteoporosis, and therefore represents a promising experimental model for studying postmenopausal bone loss. 相似文献
10.
We evaluated the bone-forming potential of isogeneic bone marrow combined with antigen-extracted, autolyzed allogeneic bone matrix (AAA bone a.m. Urist). The purpose of the experiment was to evaluate bone-inducing materials for application in orthopaedic devices designed for fixation by bone ingrowth into a porous surface. The bone-forming materials were packed into tubes of porous fiber titanium and placed in the back musculature of rats for 12 or 25 days. At 12 days the combination of bone marrow and AAA bone had produced more bone than marrow only. At 25 days, however, there was no difference. The bone-inducing materials produced substantial amounts of new bone, and may become an adjuvant for achieving fixation by bone ingrowth. In particular, a combination of AAA bone and marrow might enhance fixation at a very early postoperative stage. 相似文献