全文获取类型
收费全文 | 247篇 |
免费 | 6篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 2篇 |
基础医学 | 16篇 |
口腔科学 | 7篇 |
临床医学 | 9篇 |
内科学 | 58篇 |
神经病学 | 30篇 |
特种医学 | 14篇 |
外科学 | 35篇 |
综合类 | 1篇 |
预防医学 | 2篇 |
眼科学 | 2篇 |
药学 | 37篇 |
肿瘤学 | 35篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 5篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 5篇 |
2013年 | 3篇 |
2012年 | 6篇 |
2011年 | 9篇 |
2010年 | 11篇 |
2009年 | 8篇 |
2008年 | 10篇 |
2007年 | 11篇 |
2006年 | 17篇 |
2005年 | 23篇 |
2004年 | 14篇 |
2003年 | 20篇 |
2002年 | 20篇 |
2000年 | 5篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1996年 | 3篇 |
1995年 | 7篇 |
1994年 | 1篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1974年 | 5篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有253条查询结果,搜索用时 31 毫秒
1.
Tomohiro Saito Masahide Mizobuchi Yusuke Miwa Motonori Sugiyama Yuuki Mima Ayana Iida Nobuhiro Kanazawa Tomoki Morikawa Junichi Hayashi Kei Fukuda Yasuto Shikida Taihei Suzuki Hirokazu Honda 《Journal of clinical apheresis》2021,36(1):196-205
We present six cases of antimelanoma differentiation‐associated gene 5 antibody (anti‐MDA5‐Ab)‐positive clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP‐ILD), which is known to have a poor prognosis. The outcomes of these cases are described after treatment with therapeutic plasma exchange (TPE). Clinical and therapeutic data for patients with CADM with RP‐ILD were collected retrospectively from medical records. All six patients received early intensive care including high‐dose corticosteroids, intravenous cyclophosphamide, and a calcineurin inhibitor, but lung disease and hypoxia became more severe. TPE was performed over a median of 9.5 sessions (range 3‐14) per patient, and the median duration from admission to TPE was 23 days. Three patients received combined direct hemoperfusion using a polymyxin B‐immobilized fiber column (PMX‐DHP) therapy on successive days to manage acute respiratory failure. Four patients survived and two died due to respiratory failure. In the survival cases, ferritin decreased, and ferritin and KL‐6 were lower at diagnosis. The patients who died had a higher alveolar‐arterial oxygen difference and more severe lung lesions at the time of initiation of TPE. These findings indicate that a combination of conventional therapy and TPE may be useful for improvement of the prognosis of CADM with RP‐ILD at the early stage of onset. 相似文献
2.
3.
4.
Hideaki Hozumi Ryota Hokari Motonori Shimizu Koji Maruta Kazuyuki Narimatsu Hirokazu Sato Shingo Sato Toshihide Ueda Masaaki Higashiyama Chikako Watanabe Shunsuke Komoto Kengo Tomita Atsushi Kawaguchi Shigeaki Nagao Soichiro Miura 《Digestive endoscopy》2014,26(4):594-598
Phlebosclerotic colitis is a rare and recently known disease entity and its etiology is still to be elucidated. Some phlebosclerotic colitis cases are difficult to distinguish from collagenous colitis because of the similarity of pathological findings. In all Japanese case reports of phlebosclerotic colitis in which an association with the use of Chinese herbal medicine is suspected, sansisi (gardenia fruit) was included, suggesting pathogenesis of this disease. We report a case of phlebosclerotic colitis that wasdifficult to be distinguished from collagenous colitis, and an association with the use of Chinese herbal medicine was suspected as the cause of the disease. 相似文献
5.
Araki Y Mitsuyama K Nagae T Tou Y Nakagawa M Iwatani Y Harada M Ozasa H Sata M Noake T 《Journal of gastroenterology》2008,43(7):571-575
BACKGROUND: Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis. METHODS: Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy. RESULTS: Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8-10) to 4.0 (range, 2-8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed. CONCLUSIONS: Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial. 相似文献
6.
A combination immunochemotherapy of 5-fluorouracil, cisplatin, leucovorin, and OK-432 for advanced and recurrent gastric carcinoma 总被引:1,自引:0,他引:1
Yoshikawa T Tsuburaya A Kobayashi O Sairenji M Motohashi H Noguchi Y 《Hepato-gastroenterology》2003,50(54):2259-2263
BACKGROUND/AIMS: Based on theories of biochemical modulation and immunotherapy, a novel regimen consisting of 5-fluorouracil, cisplatin, leucovorin, and OK-432 (FLPO therapy) was devised for the treatment of patients with advanced and recurrent gastric carcinoma. METHODOLOGY: The 14-day combination therapy consisted of continuous infusion of 5-fluorouracil (250 mg/m2/day), a bolus injection of 10 mg cisplatin and 30 mg leucovorin every other day, and a subcutaneous injection or per oral administration of OK-432 (3KE or 5KE) every other day. Thirty patients completed 59 courses of treatment consisting of 2 weeks of therapy followed by at least 2 weeks rest. RESULTS: The overall response rate was 40%, with 1 complete response and 11 partial responses observed. All twelve patients responded after 1 course of treatment. The response rate differed depending upon tumor location, 22.2% at the primary site, 60.0% in the lymph nodes, 45.5% with peritoneal dissemination, 44.4% with liver metastases, 50.0% in the lung, and 100.0% with skin metastases. The most frequently observed toxicity was stomatitis (53.3%). The overall incidence of toxicities of grade 3 or greater was 6.6%, including diarrhea (3.3%) and stomatitis (3.3%). One patient required treatment interruption because of the grade 3 toxicity of diarrhea. The median survival time was 198 days overall, 242 days for responders and 125 days for non-responders. CONCLUSIONS: FLPO therapy seemed to be an effective regimen for the treatment of advanced and recurrent gastric carcinoma. 相似文献
7.
Misaki Kageyama Hideharu Hagiya Yasutaka Ueda Katsuki Ohtani Yasuo Fukumori Norimitsu Inoue Nobutaka Wakamiya Nanoka Yoneda Keigo Kimura Motonori Nagasawa Futoshi Nakagami Isao Nishi Ken Sugimoto Hiromi Rakugi 《Medicine》2021,100(13)
Rationale:Complement deficiency are known to be predisposed to disseminated gonococcal infection (DGI). We herein present a case of DGI involving a Japanese man who latently had a complement 7 deficiency with compound heterozygous variants.Patient concerns:A previously healthy 51-year-old Japanese man complained of sudden-onset high fever. Physical examination revealed various skin lesions including red papules on his trunk and extremities, an impetigo-like pustule on left forearm, and tendinitis of his right forefinger.Diagnosis:Blood culture testing detected gram-negative cocci, which was confirmed to be Neisseria gonorrhoeae based on mass spectrometry and a pathogen-specific PCR test.Interventions:Screening tests for underlying immunocompromised factors uncovered that complement activities (CH50) was undetectable. With a suspicion of a congenital complement deficiency, genetic analysis revealed rare single nucleotide variants in complement 7 (C7), including c.281-1G>T and a novel variant c.1454C>T (p.A485V). CH50 was normally recovered by adding purified human C7 to the patient''s serum, supporting that the patient has C7 deficiency with compound heterozygous variants.Outcomes:Under a diagnosis of DGI, the patient underwent an antibiotic treatment with cefotaxime for a week and was discharged without any sequela.Lessons:DGI is a rare sexually-transmitted infection that potentially induces systemic complications. Complement immunity usually defeats N. gonorrhoeae and prevents the organism from causing DGI. This case highlighted the importance of suspecting a complement deficiency when a person develops DGI. 相似文献
8.
Otsui K Inoue N Kobayashi S Shiraki R Honjo T Takahashi M Hirata K Kawashima S Yokoyama M 《Heart and vessels》2007,22(6):416-422
Toll-like receptors (TLRs) play an essential role in innate immunity as components of the primary defense system against microbial
infections. It has become evident that TLRs are also involved in the pathogenesis of various cardiovascular diseases. However,
the expression patterns of TLRs in the human coronary arteries of coronary artery disease (CAD) patients and the regulatory
mechanisms of their expression remain unknown. The TLR4 expression patterns were invstigated by immunohistochemical analysis
of coronary specimens obtained from autopsy cases or CAD patients by using directional coronary atherectomy. In atherosclerotic
coronary arteries (n = 8), TLR4 immunoreactivity was colocalized with infiltrating inflammatory cells. Interestingly, vascular smooth muscle cells
of atherosclerotic coronary arteries intensely expressed TLR4 even in the regions that had few inflammatory cells. In contrast,
TLR4 expression was barely detected in the vascular smooth muscle cells of nonatherosclerotic coronary arteries (n = 4). Furthermore, intense expression of smooth muscle TLR4 was observed in the coronary arteries of CAD patients (n = 52). Stimulation with tumor necrosis factor α and angiotensin II increased the expression of TLR4 mRNA in cultured human
vascular smooth muscle cells. Candesartan, an antagonist of the angiotensin II type 1 receptor (AT1), and N-acetylcystine inhibited angiotensin II-induced TLR4 mRNA expression in these cells. These findings suggest that the vascular
smooth muscle cells of atherosclerotic coronary arteries may be activated to express TLR4. Furthermore, proinflammatory cytokines
and oxidative stress in the inflammatory lesions might contribute to the enhanced expression of TLR4 in vascular smooth muscle
cells of atherosclerotic arteries. 相似文献
9.
Evaluation of duodenal hypersensitivity induced by duodenal acidification using transnasal endoscopy
Manabu Ishii Hiroaki Kusunoki Noriaki Manabe Tomoari Kamada Motonori Sato Hiroshi Imamura Akiko Shiotani Jiro Hata Ken Haruma 《Journal of gastroenterology and hepatology》2010,25(5):913-918
Background and Aim: Although duodenal hypersensitivity has been suggested as one of the causes of functional dyspepsia (FD), a practical method to clarify this has not yet been established. The aim of this study was to evaluate whether patients with FD have duodenal hypersensitivity to acid, using transnasal endoscopy. Methods: In all, 44 patients with FD and 16 healthy volunteers were enrolled, and all the subjects received transnasal endoscopy in the morning after overnight fasting. After ordinary transnasal endoscopy, an infusion tube was introduced into the duodenal bulb by transnasal endoscopy and acid (20 mL, 0.1 N HCl, 20 mL/min, 36.5°C) was injected via the infusion tube. The severity of 12 symptoms was assessed by each subject using a 100‐mm visual analogue scale. The maximum severity scale was defined as the maximum score of the symptom severity scale. The total score was defined as the aggregate score of the maximum severity scale of the 12 symptoms. The maximum severity scales and the total scores between patients with FD and healthy volunteers were evaluated. Results: The maximum severity scales of nine symptoms increased significantly more after acid infusion in patients with FD than in healthy volunteers (P < 0.05). There were significant differences in the total scores (patients with FD vs healthy volunteers 233.8 ± 37.8 vs 63.9 ± 14.6, mean ± standard error of the mean, P < 0.001). Conclusions: Duodenal acidification using transnasal endoscopy enabled the evaluation of duodenal hypersensitivity to acid in healthy volunteers and patients with FD. 相似文献
10.
Vitamin A‐coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis 下载免费PDF全文
Hirotaka Furuhashi Kengo Tomita Toshiaki Teratani Motonori Shimizu Makoto Nishikawa Masaaki Higashiyama Takeshi Takajo Kazuhiko Shirakabe Koji Maruta Yoshikiyo Okada Chie Kurihara Chikako Watanabe Shunsuke Komoto Suefumi Aosasa Shigeaki Nagao Junji Yamamoto Soichiro Miura Ryota Hokari 《Hepatology research》2018,48(5):397-407