全文获取类型
收费全文 | 7516篇 |
免费 | 585篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 111篇 |
儿科学 | 217篇 |
妇产科学 | 218篇 |
基础医学 | 922篇 |
口腔科学 | 171篇 |
临床医学 | 839篇 |
内科学 | 1416篇 |
皮肤病学 | 91篇 |
神经病学 | 627篇 |
特种医学 | 305篇 |
外科学 | 952篇 |
综合类 | 98篇 |
一般理论 | 6篇 |
预防医学 | 857篇 |
眼科学 | 111篇 |
药学 | 531篇 |
中国医学 | 3篇 |
肿瘤学 | 634篇 |
出版年
2023年 | 54篇 |
2022年 | 44篇 |
2021年 | 163篇 |
2020年 | 133篇 |
2019年 | 175篇 |
2018年 | 217篇 |
2017年 | 162篇 |
2016年 | 174篇 |
2015年 | 183篇 |
2014年 | 234篇 |
2013年 | 436篇 |
2012年 | 508篇 |
2011年 | 466篇 |
2010年 | 275篇 |
2009年 | 248篇 |
2008年 | 403篇 |
2007年 | 400篇 |
2006年 | 363篇 |
2005年 | 329篇 |
2004年 | 312篇 |
2003年 | 299篇 |
2002年 | 278篇 |
2001年 | 183篇 |
2000年 | 162篇 |
1999年 | 145篇 |
1998年 | 58篇 |
1997年 | 38篇 |
1996年 | 46篇 |
1995年 | 42篇 |
1994年 | 54篇 |
1993年 | 54篇 |
1992年 | 123篇 |
1991年 | 113篇 |
1990年 | 97篇 |
1989年 | 105篇 |
1988年 | 88篇 |
1987年 | 99篇 |
1986年 | 83篇 |
1985年 | 85篇 |
1984年 | 60篇 |
1983年 | 49篇 |
1982年 | 28篇 |
1981年 | 32篇 |
1980年 | 30篇 |
1979年 | 43篇 |
1978年 | 40篇 |
1977年 | 33篇 |
1976年 | 30篇 |
1969年 | 28篇 |
1966年 | 27篇 |
排序方式: 共有8109条查询结果,搜索用时 31 毫秒
1.
Dongbing Lai Emma C. Johnson Sarah Colbert Gayathri Pandey Grace Chan Lance Bauer Meredith W. Francis Victor Hesselbrock Chella Kamarajan John Kramer Weipeng Kuang Sally Kuo Samuel Kuperman Yunlong Liu Vivia McCutcheon Zhiping Pang Martin H. Plawecki Marc Schuckit Jay Tischfield Leah Wetherill Yong Zang Howard J. Edenberg Bernice Porjesz Arpana Agrawal Tatiana Foroud 《Alcoholism, clinical and experimental research》2022,46(3):374-383
2.
John W Day Richard S Finkel Claudia A Chiriboga Anne M Connolly Thomas O Crawford Basil T Darras Susan T Iannaccone Nancy L Kuntz Loren D M Peña Perry B Shieh Edward C Smith Jennifer M Kwon Craig M Zaidman Meredith Schultz Douglas E Feltner Sitra Tauscher-Wisniewski Haojun Ouyang Deepa H Chand Jerry R Mendell 《Lancet neurology》2021,20(4):284-293
3.
Qianlai Luo Jonathan N. Hofmann Ruth M. Pfeiffer Cari M. Kitahara Minkyo Song Meredith S. Shiels 《International journal of cancer. Journal international du cancer》2023,153(1):64-72
In the United States, renal cell carcinoma (RCC) incidence and the prevalence of obesity, an established risk factor for RCC, have been increasing for several decades. RCC is more common among older individuals. We sought to quantify the contribution of excess adiposity to the rising incidence of RCC among individuals 60 years or older. National Institutes of Health-American Association of Retired Persons Diet and Health Study data (n = 453 859 participants, enrolled in 1995-1996, age at enrollment 50-71 years) were used to estimate multivariable-adjusted hazard ratios (HRs) for RCC across body mass index categories and HRs associated with smoking. Population attributable fractions (PAFs) were calculated using estimated HRs and annual overweight/obesity prevalence from the National Health Interview Survey (1985-2008). PAF estimates were combined with RCC incidence from Surveillance, Epidemiology and End Results-13 to calculate annual percent changes in RCC incidence attributable (and unrelated) to overweight/obesity. We found that between 1995 and 2018, among individuals aged 60 years and older, PAF for overweight/obesity increased from 18% to 29% for all RCCs. In comparison, the PAF for smoking declined from 12% to 9%. RCC incidence increased 1.8% per year (95% confidence interval [CI] 1.5%-2.1%) overall, while RCC incidence attributable to overweight/obesity increased 3.8% per year (95%CI 3.5%-4.2%) and RCC incidence unrelated to overweight/obesity increased 1.2% per year (95% CI 0.9%-1.4%). In conclusion, overweight/obesity appears to have contributed importantly to the rising incidence of RCC in the United States since the mid-1990s. Public health interventions focused on reducing overweight and obesity could help substantially in curbing this trend. 相似文献
4.
5.
6.
Sandy Jung Meredith Allison Carissa Toop Erin Martin 《Psychiatry, Psychology and Law》2020,27(3):478-492
Sex offender registries (SORs) were established due to policies and practices intended to protect the public from individuals who commit sexually violent acts, and yet the empirical literature does not show that public SORs reduce or prevent sexual crimes. Given that politicians prominently influence SOR policies, the current study explores the views of SORs by 26 political decision-makers from Canada and the United States. Participants completed a survey on their opinions regarding SORs and their knowledge of SOR eligibility. Attitudes and political perspectives were assessed to examine their association with SOR opinions. Almost two thirds of those surveyed believed SORs should be publicly available, and one third believed SORs helped to protect the public. These beliefs were associated with those with conservative-leaning political views. These findings help us to explore the perspectives of political decision-makers and gain insight into attitudinal factors that may play a role in influencing opinions regarding SORs. 相似文献
7.
8.
Marie Warrer Petersen Tine Sylvest Meyhoff Marie Helleberg Maj-Brit Nørregaard Kjær Anders Granholm Carl Johan Steensen Hjortsø Thomas Steen Jensen Morten Hylander Møller Peter Buhl Hjortrup Mik Wetterslev Gitte Kingo Vesterlund Lene Russell Vibeke Lind Jørgensen Klaus Tjelle Thomas Benfield Charlotte Suppli Ulrik Anne Sofie Andreasen Thomas Mohr Morten H. Bestle Lone Musaeus Poulsen Mette Friberg Hitz Thomas Hildebrandt Lene Surland Knudsen Anders Møller Christoffer Grant Sølling Anne Craveiro Brøchner Bodil Steen Rasmussen Henrik Nielsen Steffen Christensen Thomas Strøm Maria Cronhjort Rebecka Rubenson Wahlin Stephan Jakob Luca Cioccari Balasubramanian Venkatesh Naomi Hammond Vivekanand Jha Sheila Nainan Myatra Christian Gluud Theis Lange Anders Perner 《Acta anaesthesiologica Scandinavica》2020,64(9):1365-1375
Introduction
Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.Methods
The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving ≥10 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.Discussion
The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.9.
Annika Mutanen Meredith Barrett Yongjia Feng Jouko Lohi Raja Rabah Daniel H. Teitelbaum Mikko P. Pakarinen 《Journal of pediatric surgery》2019,54(3):511-516
Background
Although serial transverse enteroplasty (STEP) improves function of dilated short bowel, a significant proportion of patients require repeat surgery. To address underlying reasons for unsuccessful STEP, we compared small intestinal mucosal characteristics between initial and repeat STEP procedures in children with short bowel syndrome (SBS).Methods
Fifteen SBS children, who underwent 13 first and 7 repeat STEP procedures with full thickness small bowel samples at median age 1.5 years (IQR 0.7–3.7) were included. The specimens were analyzed histologically for mucosal morphology, inflammation and muscular thickness. Mucosal proliferation and apoptosis was analyzed with MIB1 and Tunel immunohistochemistry.Results
Median small bowel length increased 42% by initial STEP and 13% by repeat STEP (p = 0.05), while enteral caloric intake increased from 6% to 36% (p = 0.07) during 14 (12-42) months between the procedures. Abnormal mucosal inflammation was frequently observed both at initial (69%) and additional STEP (86%, p = 0.52) surgery. Villus height, crypt depth, enterocyte proliferation and apoptosis as well as muscular thickness were comparable at first and repeat STEP (p > 0.05 for all). Patients, who required repeat STEP tended to be younger (p = 0.057) with less apoptotic crypt cells (p = 0.031) at first STEP. Absence of ileocecal valve associated with increased intraepithelial leukocyte count and reduced crypt cell proliferation index (p < 0.05 for both).Conclusions
No adaptive mucosal hyperplasia or muscular alterations occurred between first and repeat STEP. Persistent inflammation and lacking mucosal growth may contribute to continuing bowel dysfunction in SBS children, who require repeat STEP procedure, especially after removal of the ileocecal valve.Level of evidence
Level IV, retrospective study. 相似文献10.