全文获取类型
收费全文 | 3614篇 |
免费 | 306篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 32篇 |
妇产科学 | 42篇 |
基础医学 | 482篇 |
口腔科学 | 125篇 |
临床医学 | 355篇 |
内科学 | 779篇 |
皮肤病学 | 41篇 |
神经病学 | 262篇 |
特种医学 | 167篇 |
外科学 | 518篇 |
综合类 | 55篇 |
一般理论 | 10篇 |
预防医学 | 317篇 |
眼科学 | 34篇 |
药学 | 407篇 |
中国医学 | 5篇 |
肿瘤学 | 222篇 |
出版年
2023年 | 12篇 |
2022年 | 15篇 |
2021年 | 59篇 |
2020年 | 41篇 |
2019年 | 58篇 |
2018年 | 85篇 |
2017年 | 78篇 |
2016年 | 77篇 |
2015年 | 106篇 |
2014年 | 111篇 |
2013年 | 163篇 |
2012年 | 265篇 |
2011年 | 311篇 |
2010年 | 166篇 |
2009年 | 163篇 |
2008年 | 218篇 |
2007年 | 267篇 |
2006年 | 243篇 |
2005年 | 241篇 |
2004年 | 217篇 |
2003年 | 219篇 |
2002年 | 182篇 |
2001年 | 67篇 |
2000年 | 31篇 |
1999年 | 48篇 |
1998年 | 51篇 |
1997年 | 28篇 |
1996年 | 23篇 |
1995年 | 25篇 |
1994年 | 21篇 |
1993年 | 19篇 |
1992年 | 28篇 |
1991年 | 24篇 |
1990年 | 22篇 |
1989年 | 20篇 |
1988年 | 14篇 |
1987年 | 18篇 |
1986年 | 15篇 |
1985年 | 14篇 |
1984年 | 20篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1977年 | 13篇 |
1974年 | 7篇 |
1970年 | 8篇 |
1968年 | 8篇 |
1967年 | 9篇 |
排序方式: 共有3930条查询结果,搜索用时 203 毫秒
1.
Nicole D. Facompre Pavithra Rajagopalan Varun Sahu Alexander T. Pearson Kathleen T. Montone Claire D. James Frederico O. Gleber-Netto Gregory S. Weinstein Jalal Jalaly Alexander Lin Anil K. Rustgi Hiroshi Nakagawa Joseph A. Califano Curtis R. Pickering Elizabeth A. White Bradford E. Windle Iain M. Morgan Roger B. Cohen Phyllis A. Gimotty Devraj Basu 《International journal of cancer. Journal international du cancer》2020,147(11):3236-3249
2.
Aim
Tracheomalacia is flaccidity of the tracheal wall leading to tracheal collapse, particularly on expiration. When severe it can warrant surgical intervention. Aortopexy is one surgical option and has been described using a variety of approaches. We report outcomes of aortopexy performed via a suprasternal incision in a single centre by a single surgeon.Methods
All patients undergoing aortopexy between February 2016 and May 2018 were prospectively included. Patients were managed by a multi-disciplinary team (MDT) and underwent standardized work-up, including dynamic flexible bronchoscopy (DFB) and contrast enhanced CT. Aortopexy was performed via a suprasternal skin crease incision. Surgery was guided by intra-operative flexible bronchoscopy. Data regarding pre-operative symptoms, degree of tracheomalacia, and outcomes were recorded.Results
Twenty-two patients were included, 18 boys, median age 5?months (range 1?month–5?years). Two aortopexy sutures were used in all cases, and three patients required an additional tracheopexy suture. Median operating time was 1?h 24?min (range 47?min–2?h 35?min). Median pre-operative tracheal collapse on DFB was 85% (range 80–95%), improving to 35% (35–80%) intra-operatively. Median length of stay was 4?days (range 1–118).Conclusions
Aortopexy via a suprasternal incision is a useful treatment modality for tracheomalacia with short operating times and rapid recovery. Outcomes vary with the best results in the TOF and premature groups. Careful patient selection and MDT work-up are essential to optimize outcomes.Level of Evidence
Level 3 (Case Series). 相似文献3.
Lucy Yardley David Papo Adolfo Bronstein Michael Gresty Mark Gardner Nilli Lavie Linda Luxon 《Neuropsychologia》2002,40(4):373-383
The aim of this series of experiments was to determine whether attention is normally required for continuously processing vestibular information concerning orientation, or is required only when orientation is disrupted (eg by vestibular dysfunction or by conflicting visual and vestibular orientation cues). In the first two studies, healthy subjects were passively oscillated, and indicated when they perceived they were passing through their starting position. There was only weak evidence for interference between performance on this 'continuous orientation monitoring task' and on concurrent mental tasks. However, a third study showed that when patients with vestibular imbalance carried out the continuous orientation monitoring task their performance on a concurrent mental arithmetic task was substantially impaired. This dual task interference was correlated with inaccuracy in judging orientation on the continuous orientation monitoring task, which in turn correlated with severity of recent vestibular symptomatology (assessed by questionnaire). In a fourth experiment, disorientation was induced in healthy subjects by rotating the visual field about the line of sight. Bidirectional interference was observed between monitoring orientation (assessed by accuracy in setting a rod to the perceived vertical) and performance of an arithmetic task. Dual task interference was correlated with baseline levels of disorientation induced by the visual field, as indicated by inaccuracy in judging the visual vertical. These findings suggest that monitoring orientation makes significant demands upon cortical processing resources when disorientation is induced, whether the disorientation results from deficient sensory functioning or from ambiguous perceptual information. 相似文献
4.
5.
6.
Tass H Malik Iain A Bruce Gerard Kelly Richard T Ramsden Shakeel R Saeed 《Skull base》2007,17(4):235-238
In cases of cerebrospinal fluid (CSF) rhinorrhea following lateral skull base surgery, fibrosis and fibrin formation resulting from meningitis has been postulated as a mechanism of spontaneously resolving the CSF leak. This study was undertaken to explore any possible relationship between the cessation of CSF leak and meningitis. A retrospective study at a tertiary referral center of 232 consecutive patients was performed. Out of a total of 232 procedures, 29 patients developed CSF rhinorrhea, of whom 7 subsequently developed meningitis. Bacteria were isolated in CSF obtained at lumbar puncture in 5 cases, with the CSF analysis in the remaining 2 cases suggesting aseptic meningitis. Conservative treatment failed to stop the CSF rhinorrhea in 6 of 7 cases. In this study, the development of meningitis did not appear to aid in the resolution of the CSF rhinorrhea. We conclude that surgical intervention should not be delayed in the expectation that meningitis and conservative interventions may promote CSF leak resolution. 相似文献
7.
8.
PLASMA FOLLISTATIN CONCENTRATIONS INCREASE FOLLOWING LIPOPOLYSACCHARIDE ADMINISTRATION IN SHEEP 总被引:1,自引:0,他引:1
Rudi Klein Iain J. Clarke† Mark P. Hedger† David M. Robertson† 《Clinical and experimental pharmacology & physiology》1996,23(8):754-755
1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plasma follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response. 相似文献
9.
Emma L Wignall Jon M Dickson Paul Vaughan Tom F D Farrow Iain D Wilkinson Michael D Hunter Peter W R Woodruff 《Neuropsychopharmacology》2004,56(11):832-836
BACKGROUND: Previous structural magnetic resonance (MR) research in patients with posttraumatic stress disorder (PTSD) has found smaller hippocampal volumes in patients compared with control subjects. These studies have mostly involved subjects who have had PTSD for a number of years, such as war veterans or adult survivors of childhood abuse. Patients with recent-onset PTSD have rarely been investigated. To our knowledge only one other study has investigated such a group. The aim of this study was to compare hippocampal volumes of patients with recent onset PTSD and nontrauma-exposed control subjects. METHODS: Fifteen patients with PTSD, recruited from an accident and emergency department, were compared with 11, non-trauma-exposed, healthy control subjects. Patients underwent a structural MR scan soon after trauma (mean time = 158 +/- 41 days). Entire brain volumes, voxel size 1 x 1 x 1 mm, were acquired for each subject. Point counting and stereology were used to measure the hippocampal and amygdala volume of each subject. RESULTS: Right-sided hippocampal volume was significantly smaller in PTSD patients than control subjects after controlling for effects of whole brain volume and age. Neither left nor total hippocampal volume were significantly smaller in the PTSD group after correction. Whole brain volume was also found to be significantly smaller in patients. There were no differences in amygdala or white matter volumes between patients and control subjects. CONCLUSIONS: This result replicates previous findings of smaller hippocampal volumes in PTSD patients, but in an underinvestigated population, suggesting that either smaller hippocampal volume is a predisposing factor in the development of PTSD or that damage occurs within months of trauma, rather than a number of years. Either of these two hypotheses have significant implications for the treatment of PTSD. For instance, if it could be shown that screening for hippocampal volume may, in some cases, predict those likely to develop clinical PTSD. 相似文献
10.