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Ercan Nain Ayca Kiykim Ismail Ogulur Nurhan Kasap Elif Karakoc‐Aydiner Ahmet Ozen Safa Baris 《Scandinavian journal of immunology》2019,90(5)
We evaluated 18 DiGeorge syndrome (DGS) patients and aimed to investigate the immunological changes in this population. DGS patients with low naive CD4+T and CD8+T cells were defined as high‐risk (HR) patients, whereas patients with normal numbers of naive CD4+ and CD8+T cells were defined as standard risk (SR) patients. Level of serum IgM, CD3+ T cell counts and percentages of class‐switched memory B cells were significantly low in HR group compared to SR ones. Severe infections and persistent hypoparathyroidism were detected significantly higher in HR group. Patients with reduced percentages of class‐switched B cells had earlier onset of infection, lower blood IgM, lower CD4+ and CD8+T counts than patients with normal class‐switched memory B cells. Decreased levels of IgM were associated with low numbers of naive CD4+ and recent thymic emigrants T cells. Monitoring the immune changes of patients with DGS would be useful to predict the severe phenotype of disease. 相似文献
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Güneri P Unlü F Yeşilbek B Bayraktar F Kokuludağ A Hekimgil M Boyacioğlu H 《Journal of periodontology》2004,75(1):91-97
BACKGROUND: Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients may depend on vascular endothelial growth factor (VEGF) actions. Few reports are available about the mechanism of neovascularization and the angiogenic factors that contribute to the periodontal pathology and the role of VEGF in periodontal diseases. The aim of this study is to compare VEGF expression in healthy and periodontally diseased tissues with gingival crevice fluid (GCF) of healthy persons and diabetic patients. METHODS: Gingival tissue and GCF samples were collected from sites of periodontitis in 10 healthy subjects and in 10 type 2 diabetic patients, and from the sites of healthy gingiva within the same groups. Therefore, each patient became his/her own control. Additionally, 10 people without any systemic or periodontal diseases were enrolled, forming a negative control group. Thus, a total of 50 tissue and 50 GCF samples were provided. RESULTS: No VEGF staining was observed in the negative control group or in the systemically healthy people's healthy tissue samples, whereas four samples of diabetic patients showed positive staining (P < 0.05). However, VEGF was revealed in two tissue samples of periodontal sites of systemically healthy people and in six samples of the diabetic patients (P > 0.05). In all test groups, GCF VEGF levels were higher in periodontal sites (P < 0.05) than in healthy sites. CONCLUSION: The results of this study showed that VEGF is increased in all periodontal tissues of both groups and in the healthy sites of diabetic patients. Additionally, GCF VEGF values increased in periodontal sites of all test groups. 相似文献
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This study sought to evaluate the influence of a dentin desensitizer and ozone application on the bond strength to dentin of a composite resin material. The dentin desensitizing agent and ozone treatment were applied on the cervical dentin surfaces of extracted, caries-free, erupted third molars. Dentin surfaces that received no treatment were used as control samples. A dentin bonding agent was applied according to the manufacturer's instructions and an adhesion test was performed according to ISO/TS 11405. Statistical analysis showed no significant influence of the different hypersensitivity treatments on shear bond strength to dentin (ANOVA and Tukey's tests, p > 0.05). Within the limitations of this in vitro study, it appears that the short-term use of dentin hypersensitivity treatments like ozone and dentin desensitizers containing gluteraldehyde do not further affect the shear bond strength to dentin of subsequent composite resin restorations. 相似文献
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Jennifer K. Logan Soroush Rais‐Bahrami Baris Turkbey Andrew Gomella Hayet Amalou Peter L. Choyke Bradford J. Wood Peter A. Pinto 《BJU international》2014,114(5):641-652
Prostate MRI is currently the best diagnostic imaging method for detecting PCa. Magnetic resonance imaging (MRI)/ultrasonography (US) fusion allows the sensitivity and specificity of MRI to be combined with the real‐time capabilities of transrectal ultrasonography (TRUS). Multiple approaches and techniques exist for MRI/US fusion and include direct ‘in bore’ MRI biopsies, cognitive fusion, and MRI/US fusion via software‐based image coregistration platforms. 相似文献
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A. Altunoglu D. Yavuz M. Batur Canoz R. Yavuz Latife A. Karakaş N. Bayraktar T. Colak S. Sezer F. Nurhan Ozdemir M. Haberal 《Transplantation proceedings》2014
Background
Patients with end-stage renal disease (ESRD) experience female sexual dysfunction (FSD). The purpose of this study was to compare FSD in different types of renal replacement therapy and control patients.Methods
The study was consisted of 47 renal transplantation (RT), 46 hemodialysis (HD), and 28 continuous ambulatory peritoneal dialysis (CAPD) patients and 36 healthy control subjects. All groups were evaluated with the following scales: Female Sexual Function Index (FSFI) questionnaire, Short Form (SF)–36 questionnaires, and Beck Depression Inventory (BDI). Demographic data, laboratory values, and hormone levels were obtained. The patients with FSFI score <26.55 were accepted as experiencing sexual dysfunction.Results
Overall, total FSFI scores in RT, HD, CAPD, and control were 22 (range, 2–35), 22.4 (4–34), 18.35 (2–34), and 29.6 (2–35), respectively. The mean total FSFI score was not different in patients receiving different kinds of renal replacement therapy (P > .05) although they were significantly worse then the control group (P < .001). On regression analysis, age was significantly associated with FSD (β = −0.14; P = .001). In addition, the physiologic health domain of SF-36 was significantly better in control groups (P < .001). The difference in terms of mean of BDI score did not reach statistical significance among patient groups (P > .05). Female sexual dysfunction score was negatively correlated with BDI (r = −0.371; P < .001) and positively correlated with the mental-physical components score of SF-36 (r = 0.423 [P < .001] and r = 0.494 [P < .001], respectively) in all patients groups. Regarding the hormones of the patients, there was a significant difference between RT and the HD and CAPD groups in dihydroepiandrosterone sulfate (DHEAS; P < .001), RT and HD in prolactin (P < .001), and RT and CAPD in free testesterone (P < .001).Conclusions
Renal transplantation, hemodialysis, and peritoneal dialysis patients were at more risk of developing sexual dysfunction and lower quality of life scores than healthy subjects. Notably, the mode of renal replacement therapy had no impact on female sexual function. 相似文献9.
Arel Gereli Ufuk Nalbantoglu Baris Kocaoglu Metin Turkmen 《Archives of orthopaedic and trauma surgery》2014,134(1):121-129
Introduction
The present study was designed to demonstrate the efficacy of standard 4.0 mm cannulated screw fixation by comparing it with palmar locking plate fixation in the treatment of acute, unstable, simple extra-articular distal radius fractures.Materials and methods
We prospectively collected and retrospectively analyzed outcomes data for 65 patients aged between 18 and 60 with AO type A2 fractures treated with closed reduction, percutaneous cannulated screw fixation (CRPCS n = 34) or open reduction palmar locking plate fixation (ORPLP n = 31). Range of motion, grip strength, Gartland–Werley and QuickDASH scores were compared at 2 months after surgery, and final follow-up (mean 32 months, range 12–90). Deterioration in radiographic parameters were measured and compared. Operative time and return to preinjury activity were evaluated.Results
Parameters did not differ significantly between the groups at either time point with respect to grip strength or range of motion, except pronation and supination; they were better in the CRPCS group (p = 0.005 and 0.025, respectively) at 2 month follow-up. The Gartland–Werley and QuickDASH scores obtained at final follow-up were similar for each group and lacked statistical significance. Group comparison for the deterioration of radiologic parameters showed no significant difference. CRPCS group had significantly shorter operative time (p = 0.001) and there was no significant differences between the groups regarding the return to preinjury activity (p = 0.129).Conclusions
CRPCS group was found to be as successful as ORPLP group and it may be suitable in the case of young, active individuals with AO type A2 distal radius fractures. 相似文献10.
Ibrahim Ali Ozemir Cagri Bilgic Baris Bayraktar Sinan Aslan Ebru Zemheri Haydar Yalman Rafet Yigitbasi 《International journal of surgery case reports》2014,5(8):480-483