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Background

Alteplase is a recombinant tissue plasminogen activator that is approved for the treatment of occluded central venous access devices (CVADs) and is commercially available as a 2?mg/2?mL dose. Due to the increasing price of 2?mg/2?mL alteplase vials, our institution switched to using a 1?mg/1?mL dose for certain CVADs. The purpose of this study was to evaluate the use, effectiveness, and cost of a maximum of 2 doses of 1?mg/1?mL alteplase for the restoration of an occluded catheter.

Methods

A report was generated to identify patients who were administered 1?mg alteplase during the period May 2016 through July 2016. A chart review was performed on each patient identified to collect the data needed, such as documentation of a dysfunctional lumen and documentation of patency after alteplase 1?mg was given. To determine the cost of waste, expired 1-mg syringes returned to the pharmacy were collected.

Results

In total, there were 524 1-mg alteplase doses administered during the 3-month time frame. The effectiveness after the first and second dose was 88% and 80%, respectively. Thirty-four doses were wasted, resulting in a cost of around $2,200. It is estimated that the 1-mg syringes provided the institution with $136,000 in annualized savings.

Conclusions

It is beneficial to use 1?mg alteplase for occluded CVADs. The cost of waste is nominal compared with the cost savings for the institution. The next step is to analyze other doses of alteplase to find additional areas of cost savings.  相似文献   
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European Archives of Psychiatry and Clinical Neuroscience - Insight into illness in schizophrenia (SZ) patients has a major impact on treatment adherence and outcome. Previous studies have linked...  相似文献   
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To guide targeted cessation and prevention programming, this study assessed smoking prevalence and described sociodemographic, health, and healthcare use characteristics of adult smokers in public housing. Self-reported data were analyzed from a random sample of 1664 residents aged 35 and older in ten New York City public housing developments in East/Central Harlem. Smoking prevalence was 20.8%. Weighted log-binomial models identified to be having Medicaid, not having a personal doctor, and using health clinics for routine care were positively associated with smoking. Smokers without a personal doctor were less likely to receive provider quit advice. While most smokers in these public housing developments had health insurance, a personal doctor, and received provider cessation advice in the last year (72.4%), persistently high smoking rates suggest that such cessation advice may be insufficient. Efforts to eliminate differences in tobacco use should consider place-based smoking cessation interventions that extend cessation support beyond clinical settings.  相似文献   
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