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Parasitology Research - The level of genetic variability of Giardia intestinalis clinical isolates is an intensively studied and discussed issue within the scientific community. Our collection of... 相似文献
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Prospective study of signalling pathways in myeloma bone disease with regard to activity of the disease,extent of skeletal involvement and correlation to bone turnover markers 下载免费PDF全文
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Prevalence of youth gambling and potential influence of substance use and other risk factors throughout 33 European countries: first results from the 2015 ESPAD study 下载免费PDF全文
Sabrina Molinaro Elisa Benedetti Marco Scalese Luca Bastiani Loredana Fortunato Sonia Cerrai Natale Canale Pavla Chomynova Zsuzsanna Elekes Fernanda Feijão Anastasios Fotiou Anna Kokkevi Ludwig Kraus Liudmila Rupšienė Karin Monshouwer Alojz Nociar Julian Strizek Tanja Urdih Lazar 《Addiction (Abingdon, England)》2018,113(10):1862-1873
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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling 下载免费PDF全文
Brdicka T Imrich M Angelisová P Brdicková N Horváth O Spicka J Hilgert I Lusková P Dráber P Novák P Engels N Wienands J Simeoni L Osterreicher J Aguado E Malissen M Schraven B Horejsí V 《The Journal of experimental medicine》2002,196(12):1617-1626
A key molecule necessary for activation of T lymphocytes through their antigen-specific T cell receptor (TCR) is the transmembrane adaptor protein LAT (linker for activation of T cells). Upon TCR engagement, LAT becomes rapidly tyrosine phosphorylated and then serves as a scaffold organizing a multicomponent complex that is indispensable for induction of further downstream steps of the signaling cascade. Here we describe the identification and preliminary characterization of a novel transmembrane adaptor protein that is structurally and evolutionarily related to LAT and is expressed in B lymphocytes, natural killer (NK) cells, monocytes, and mast cells but not in resting T lymphocytes. This novel transmembrane adaptor protein, termed NTAL (non-T cell activation linker) is the product of a previously identified WBSCR5 gene of so far unknown function. NTAL becomes rapidly tyrosine-phosphorylated upon cross-linking of the B cell receptor (BCR) or of high-affinity Fcgamma- and Fc epsilon -receptors of myeloid cells and then associates with the cytoplasmic signaling molecules Grb2, Sos1, Gab1, and c-Cbl. NTAL expressed in the LAT-deficient T cell line J.CaM2.5 becomes tyrosine phosphorylated and rescues activation of Erk1/2 and minimal transient elevation of cytoplasmic calcium level upon TCR/CD3 cross-linking. Thus, NTAL appears to be a structural and possibly also functional homologue of LAT in non-T cells. 相似文献
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Toplak N Frenkel J Ozen S Lachmann HJ Woo P Koné-Paut I De Benedetti F Neven B Hofer M Dolezalova P Kümmerle-Deschner J Touitou I Hentgen V Simon A Girschick H Rose C Wouters C Vesely R Arostegui J Stojanov S Ozgodan H Martini A Ruperto N Gattorno M;Paediatric Rheumatology International Trials Organisation 《Annals of the rheumatic diseases》2012,71(7):1177-1182