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Mitsuru Kashiwagi Takuya Tanabe Shuichi Shimakawa Michiko Nakamura Shinya Murata Kousuke Shabana Jun Shinohara Yutaka Odanaka Hideki Matsumura Koh Maki Kenichi Okumura Keisuke Okasora Hiroshi Tamai 《Brain & development》2014
Recently, many cases of children presenting reversible splenial lesions during febrile illness (RESLEF) have been reported; however, their overall clinico-radiological features are unclear. 相似文献
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We propose a quite simple, recursive algorithm of image reconstruction in computer tomography (CT) based only on Bayes' theorem. Object image estimation is carried out with detection or coincidence event-base for emission type CT, and projection event-base for transmission type CT. This event-base method implies, in principle, real-time image reconstruction in CT, and provides a new paradigm called structure adaptive CT, such as parameter adjustable and regions-of-interest CTs. 相似文献
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Metabolic fate of ethylenethiourea in pregnant rats 总被引:3,自引:0,他引:3
Y. Kato Y. Odanaka S. Teramoto O. Matano 《Bulletin of environmental contamination and toxicology》1976,16(5):546-555
Summary Metabolic fate of ETU was investigated in the rats administered orally 100 mg/ kg of C14-ETU on the twelfth day of gestation.ETU was absorbed readily from the gastrointestinal tract and passed away from the whole body tissues including the fetus rapidly. Only the exception was the thyroid gland and the radio-activity was accumulated in the gland. Most of the administered activity(80.2%,4,5-C14-ETU) was eliminated into the urine in 24 hr and the tissues(including the fetus) levels of radioactivity from 2-C14 -ETU reached maximal within 2 hr and fell down to negligible levels by 24 hr.Radiocarbon(s)of 4,5-C14-ETU was expired as radioactive carbon dioxide and was incorporated into the serum and fetal cell constituents(crude protein fraction),but that of 2-C14-ETU was neither expired or incorporated into the cell constituents.From the fetus extract ETU and several radioactive metabolites were detected. 相似文献
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Kitagawa H Pringle KC Koike J Zuccollo J Sato Y Sato H Fujiwaki S Odanaka M Nakada K 《Journal of pediatric surgery》2004,39(12):1845-1848
Purpose
Our obstructive uropathy model in fetal lambs showed that renal cystic changes appeared 3 weeks after obstruction. In this study, the authors investigated the changes resulting from complete urinary tract obstruction in the first 7 days after obstruction.Methods
An obstructive uropathy was created in fetal lambs at 60 days’ gestation by ligating the urethra and urachus. They were delivered 48 hours, 3 days, 5 days, and 7 days later by cesarian section. The kidneys were removed and processed for histologic examination.Results
Eighteen fetuses were operated on and 15 (4 at 48 hours, 4 at 3 days, 2 at 5 days, and 5 at 7 days; 83%) survived. Macroscopically, bladder dilatation and slightly dilated ureters were identified from 48 hours. Microscopically, dilatation of proximal tubules started from 48 hours after obstruction and increased by 7 days. Glomerular cysts in the nephrogenic zone also were identified from 48 hours. Dysplastic changes were not found.Conclusions
The first areas in the developing kidney that suffer damage after obstructive uropathy are the proximal tubule and the nephrogenic zone. This change started 48 hours after obstruction. Shunting procedures need to be performed considerably earlier than previously thought. 相似文献8.
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Ueda H Ebino K Fujie H Hayashi K Satoh M Nakashima N Chiba Y Harada T Saka M Koma Y Nagata T Odanaka Y Teramoto S 《Regulatory toxicology and pharmacology : RTP》2005,41(3):167-174
Ecotoxicological hazards of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT) were investigated by a one-generation reproduction study using Japanese quail (Coturnix coturnix japonica) under an Organization for Economic Co-operation and Development (OECD) draft new test guideline 206 following acute and subchronic toxicity studies. In the subchronic feeding toxicity study, tremors, convulsions, and deaths were observed with a clear sex difference, males being more susceptible than females. The estimated total number of sperm tended to decrease in a dose-dependent manner at the end of 6-week treatment. In the one-generation reproduction study conducted at dose levels of 0, 6, 30, and 150 ppm, the estimated total number of sperm tended to decrease in a dose-dependent manner with a significant difference at 150 ppm. Tremors were observed in the majority of hatchlings in the 150 ppm group and at lower incidences in the 30 ppm group. Significantly high mortality rate in chicks persisted from treatment week 3-6 in the 150 ppm group and at treatment weeks 4 and 5 in the 30 ppm group. Despite of these severe adverse effects of p,p'-DDT on hatchlings and chicks, fertilization, egg laying, eggshell thickness or embryonic development was hardly impaired by p,p'-DDT or its metabolites. From these results, it appears that the OECD draft new avian one-generation reproduction test guideline is effective for ecological hazard assessment of chemicals. 相似文献
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Okumura H Nishimura E Kariya S Ohtani M Uchino K Fukatsu T Odanaka J Takahashi T Watanabe K Itoh T Hashiguchi M Echizen H Rikihisa T 《Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan》2001,121(3):253-257
Persistent dry cough is well known as the most common side-effect of angiotensin-converting enzyme (ACE) inhibitors. We examined the relationship between a cough and ACE gene polymorphism, plasma bradykinin (BK), substance P (SP) and ACE inhibitor concentrations in patients with hypertension or chronic nephritis. First, ACE genotyping was carried out in 96 patients, 42 with coughs and 54 without coughs, which had been treated with various kinds of ACE inhibitors. However, no significant difference in the ACE genotypes was observed between the two groups. Second, the plasma concentrations of BK, SP and ACE inhibitor were measured in 12 patients, which were treated with trandolapril at a daily dose of 1 mg for 4-33 weeks. In 3 patients, the cough was induced during the trandolapril therapy, while it was induced not in 9 patients. The plasma levels of BK and SP did not significantly change after trandolapril administration in the patients with and without coughs. Between the two groups, there were no significant differences in the plasma levels of BK and SP either before or after the trandolapril therapy. Also the plasma concentrations of trandolapril and trandolaprilat, the active metabolite of trandolapril, did not significantly differ between the two groups. These results suggest that there is no significant relationship between the ACE inhibitor-induced cough and ACE gene polymorphism, plasma BK, SP and ACE inhibitor concentrations in patients with hypertension or chronic nephritis. 相似文献