全文获取类型
收费全文 | 35351篇 |
免费 | 1948篇 |
国内免费 | 94篇 |
专业分类
耳鼻咽喉 | 710篇 |
儿科学 | 1415篇 |
妇产科学 | 643篇 |
基础医学 | 4164篇 |
口腔科学 | 695篇 |
临床医学 | 2649篇 |
内科学 | 8860篇 |
皮肤病学 | 1321篇 |
神经病学 | 2810篇 |
特种医学 | 865篇 |
外科学 | 4956篇 |
综合类 | 146篇 |
一般理论 | 14篇 |
预防医学 | 3055篇 |
眼科学 | 891篇 |
药学 | 2021篇 |
中国医学 | 84篇 |
肿瘤学 | 2094篇 |
出版年
2023年 | 201篇 |
2022年 | 121篇 |
2021年 | 885篇 |
2020年 | 461篇 |
2019年 | 971篇 |
2018年 | 1384篇 |
2017年 | 864篇 |
2016年 | 786篇 |
2015年 | 832篇 |
2014年 | 1025篇 |
2013年 | 1493篇 |
2012年 | 2509篇 |
2011年 | 2631篇 |
2010年 | 1399篇 |
2009年 | 1085篇 |
2008年 | 2078篇 |
2007年 | 2325篇 |
2006年 | 2129篇 |
2005年 | 2153篇 |
2004年 | 1916篇 |
2003年 | 1804篇 |
2002年 | 1753篇 |
2001年 | 1124篇 |
2000年 | 1387篇 |
1999年 | 1037篇 |
1998年 | 186篇 |
1997年 | 126篇 |
1996年 | 131篇 |
1995年 | 97篇 |
1994年 | 79篇 |
1993年 | 72篇 |
1992年 | 354篇 |
1991年 | 255篇 |
1990年 | 214篇 |
1989年 | 165篇 |
1988年 | 162篇 |
1987年 | 160篇 |
1986年 | 137篇 |
1985年 | 121篇 |
1984年 | 93篇 |
1983年 | 79篇 |
1982年 | 32篇 |
1981年 | 39篇 |
1980年 | 35篇 |
1979年 | 57篇 |
1976年 | 35篇 |
1974年 | 34篇 |
1973年 | 39篇 |
1971年 | 30篇 |
1970年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Antonio Montalvo Afonso Fernando Ruiz Juretschke Rosario González Rodrigálvarez Olga Mateo Sierra Begoña Iza Vallejo Roberto García Leal Marc Valera Melé Vicente Casitas Hernando Jose Manuel Hernández Poveda Carlos Fernández Carballal 《Neurocirugía (Asturias, Spain)》2021,32(1):1-9
Background and objectivesThe treatment of deafferentation pain by spinal DREZotomy is a proven therapeutic option in the literature. In recent years, use of DREZotomy has been relegated to second place due to the emergence of neuromodulation therapies. The objectives of this study are to demonstrate that DREZotomy continues to be an effective and safe treatment and to analyse predictive factors for success.Patients and methodsA retrospective study was conducted of all patients treated in our department with spinal DREZotomy from 1998 to 2018. Bulbar DREZotomy procedures were excluded. A visual analogue scale (VAS) and the reduction of routine medication were used as outcome variables. Demographic, clinical and operative variables were analysed as predictive factors for success.ResultsA total of 27 patients (51.9% female) with a mean age of 53.7 years underwent DREZotomy. The main cause of pain was brachial plexus injury (BPI) (55.6%) followed by neoplasms (18.5%). The mean time of pain evolution was 8.4 years with a mean intensity of 8.7 according to the VAS, even though 63% of the patients had previously received neurostimulation therapy. Favourable outcome (≥ 50% pain reduction in the VAS) was observed in 77.8% of patients during the postoperative period and remained in 59.3% of patients after 22 months average follow-up (mean reduction of 4.9 points). This allowed for a reduction in routine analgesic treatment in 70.4% of them. DREZotomy in BPI-related pain presented a significantly higher success rate (93%) than the other pathologies (41.7%) (p = .001). No association was observed between outcome and age, gender, DREZ technique, duration of pain or previous neurostimulation therapies. There were six neurological complications, four post-operative transient neurological deficits and two permanent deficits.ConclusionDorsal root entry zone surgery is effective and safe for treating patients with deafferentation pain, especially after brachial plexus injury. It can be considered an alternative treatment after failed neurostimulation techniques for pain control. However, its indication should be considered as the first therapeutic option after medical therapy failure due to its good long-term results. 相似文献
2.
Pauline A. J. Mendelaar Jaco Kraan Mai Van Leonie L. Zeune Leon W. M. M. Terstappen Esther Oomende Hoop John W. M. Martens Stefan Sleijfer 《Molecular oncology》2021,15(1):116
Circulating tumor cells (CTCs) in the blood of cancer patients are of high clinical relevance. Since detection and isolation of CTCs often rely on cell dimensions, knowledge of their size is key. We analyzed the median CTC size in a large cohort of breast (BC), prostate (PC), colorectal (CRC), and bladder (BLC) cancer patients. Images of patient‐derived CTCs acquired on cartridges of the FDA‐cleared CellSearch® method were retrospectively collected and automatically re‐analyzed using the accept software package. The median CTC diameter (μm) was computed per tumor type. The size differences between the different tumor types and references (tumor cell lines and leukocytes) were nonparametrically tested. A total of 1962 CellSearch® cartridges containing 71 612 CTCs were included. In BC, the median computed diameter (CD) of patient‐derived CTCs was 12.4 μm vs 18.4 μm for cultured cell line cells. For PC, CDs were 10.3 μm for CTCs vs 20.7 μm for cultured cell line cells. CDs for CTCs of CRC and BLC were 7.5 μm and 8.6 μm, respectively. Finally, leukocytes were 9.4 μm. CTC size differed statistically significantly between the four tumor types and between CTCs and the reference data. CTC size differences between tumor types are striking and CTCs are smaller than cell line tumor cells, whose size is often used as reference when developing CTC analysis methods. Based on our data, we suggest that the size of CTCs matters and should be kept in mind when designing and optimizing size‐based isolation methods.
Abbreviations
- ACCEPT
- Automated CTC Classification, Enumeration, and PhenoTyping software
- BC
- breast cancer
- BLC
- bladder cancer
- CD
- computed diameter
- CEL
- cultured tumor cell (cell line)
- CK
- cytokeratin
- CRC
- colorectal cancer
- CTC‐L
- circulating tumor cells derived from cerebrospinal fluid (liquor)
- CTCs
- circulating tumor cells
- DAPI
- 4′6‐diamidino‐2‐phenylindole
- EMT
- epithelial–mesenchymal transition
- EpCAM
- epithelial cell adhesion molecule
- IQR
- interquartile range
- KW test
- Kruskal–Wallis test
- MWU test
- Mann–Whitney U test
- NCR
- nucleus/cytoplasm ratio
- P2A
- perimeter to area
- PC
- prostate cancer
- TIF
- tagged Image Format files
- TXT
- text file
- μm
- micrometer
- µm2
- square micrometers
3.
Ana Rodríguez Cala Candela Calle Rodríguez Noemí Durán García Barbara Zöller Ana Pons Rodríguez 《Gaceta sanitaria / S.E.S.P.A.S》2021,35(1):67-71
The adoption of a management approach that integrates corporate social responsibility in organizations is an increasing trend that responds to the demands of society related to sustainability, ethics and transparency. Health organizations are adopting corporate social responsibility asymmetrically, which raises the analysis of the implementation models and the developed initiatives. Through qualitative research, with four in-depth case studies of the Catalan health sector, this article analyzes the need to address this new approach and to identify good practices and the challenges for its implementation. 相似文献
4.
I. Cifuentes García C. Ariza Molina I.D. Domínguez Paillacho I. González-Huebra C. Lanciego 《Radiologia》2021,63(2):170-179
This paper aims to describe our experience in an interventional radiology unit in a hospital in Spain that was severely affected by the COVID-19 pandemic. To this end, we did a prospective observational study of 20 consecutive patients with COVID-19 who underwent 21 interventional radiology procedures between March 13, 2020 and May 11, 2020. We describe the measures taken to reorganize the work and protective measures, as well as the repercussions of the situation on our unit's overall activity and activity in different phases. The COVID-19 pandemic has represented a challenge in our daily work, but learning from our own experience and the recommendations of the Spanish radiological societies (SERVEI and SERAM) has enabled us to adapt successfully. Our activity dropped only 22% compared to the same period in 2019. 相似文献
5.
R. García-Ramos D. Santos-García A. Alonso-Cánovas M. Álvarez-Sauco B. Ares A. Ávila N. Caballol F. Carrillo F. Escamilla Sevilla E. Freire J.C. Gómez Esteban I. Legarda L. López Manzanares E. López Valdés I. Martínez-Torres M. Mata I. Pareés B. Pascual-Sedano J.C. Martínez Castrillo 《Neurología (Barcelona, Spain)》2021,36(2):149-158
IntroductionThe main challenge of Parkinson's disease in women of childbearing age is managing symptoms and drugs during pregnancy and breastfeeding. The increase in the age at which women are having children makes it likely that these pregnancies will become more common in future.ObjectivesThis study aims to define the clinical characteristics of women of childbearing age with Parkinson's disease and the factors affecting their lives, and to establish a series of guidelines for managing pregnancy in these patients.ResultsThis consensus document was developed through an exhaustive literature search and a discussion of the available evidence by a group of movement disorder experts from the Spanish Society of Neurology.ConclusionsParkinson's disease affects all aspects of sexual and reproductive health in women of childbearing age. Pregnancy should be well planned to minimise teratogenic risk. A multidisciplinary approach should be adopted in the management of these patients in order to take all relevant considerations into account. 相似文献
6.
7.
8.
9.
10.
Joshua Demb Esther K. Wei Monika Izano Stephen Kritchevsky Helen Swede Anne B. Newman Michael Shlipak Tomi Akinyemiju Steven Gregorich Dejana Braithwaite 《Journal of Geriatric Oncology》2019,10(2):265-271