Chronic inflammation and risk of lung cancer in older adults in the health,aging and body composition cohort study |
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Authors: | Joshua Demb Esther K Wei Monika Izano Stephen Kritchevsky Helen Swede Anne B Newman Michael Shlipak Tomi Akinyemiju Steven Gregorich Dejana Braithwaite |
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Institution: | 1. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States;2. California Pacific Medical Center Research Institute, San Francisco, CA, United States;3. Department of Epidemiology, University of California, Berkeley, CA, United States;4. Wake Forest School of Medicine, Winston-Salem, NC, United States;5. Department of Community Medicine and Healthcare, University of Connecticut School of Medicine, Farmington, CT, United States;6. School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States;7. Department of Epidemiology, University of Kentucky, Lexington, KY, United States;8. Department of Medicine, University of California, San Francisco, CA, United States;9. Department of Oncology, Georgetown University, Washington, DC, United States |
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Abstract: | ObjectivesWe examined the association between three inflammatory markers (Interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) and incident lung cancer using baseline, updated, and averaged inflammatory measures in older adults.MethodsWe fitted multivariable Cox models to assess whether circulating levels of inflammation markers were associated with incident lung cancers in the Health Aging, Body and Composition (HealthABC) prospective cohort of 3075 older adults aged 70–79?years at baseline. IL-6 and CRP were measured biennially, whereas TNF-α was measured at baseline.ResultsBaseline levels of IL-6 were significantly associated with incident lung cancer risk in a model that adjusted for age, gender, race, and site (Model 1) (Hazard RatioT3 vs. T1: 3.34, 95% Confidence Interval: 1.91, 5.85) and in a model adjusted for health factors linked to chronic inflammation (Model 2) (HR T3 vs. T1: 2.57, 95% CI: 1.41, 4.65). The associations observed in time-updated IL-6 (HR T3 vs. T1: 2.47, 95% CI: 1.43, 4.28), cumulatively averaged IL-6 (HR T3 vs. T1: 2.47, 95% CI: 1.43, 4.35), and baseline CRP levels (HR T3 vs. T1: 1.85, 95% CI: 1.11, 3.08) with incident lung cancer in Model 1 were not statistically significant in Model 2.ConclusionsBaseline CRP and IL-6 levels were associated with increased risk of lung cancer in Model 1 and both models, respectively. Chronic IL-6 inflammation, as quantified by repeated measures was associated with incident lung cancer in Model 1, but not Model 2. Further research is needed to understand the role of CRP and IL-6 in lung carcinogenesis. |
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Keywords: | Health ABC Study Health Aging and Body Composition Study Vs versus C-reactive protein CRP Interleukin-6 IL-6 Tumor necrosis factor-α TNF-α BMI body mass index HR hazard ratio SHR subdistribution hazard ratio 95% CI 95% confidence interval kg kilograms L liters mg milligrams mL milliliters μg micrograms pg picograms cm centimeters ICD International Classification of Diseases IQ interquartile range Lung cancer Inflammatory markers Incidence Pulmonary |
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