Multiplication of the late slow component of the evoked potential to light during chlorpromazine administration

In experiments on unanesthetized rabbits with electrodes permanently implanted into various brain formations the effect of chlorproniazine was studied on the phenomenon of multiplication of the late slow component of the evoked potential to flashes of light applied at a frequency of 1 Hz, some of which were given simultaneously with electric shocks to the hind limb. Chlorpromazine was found to reduce the multiplication of the slow component to flashes applied without electric shocks and to facilitate the reduplication of this component to flashes applied along with the nociceptive stimulation. In the discussion of the results a role of adrenergic structures is postulated in the formation of the defensive action acceptor, one of the most important and crucial mechanisms of the functional system.Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 9, pp. 3–7, September, 1975.