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Perkins Jessica M. Kakuhikire Bernard Baguma Charles Rasmussen Justin D. Satinsky Emily N. Kiconco Allen Kananura Justus Audet Carolyn M. Siedner Mark J. Haberer Jessica E. Bangsberg David R. Tsai Alexander C. 《AIDS and behavior》2022,26(6):1892-1904
AIDS and Behavior - Although misperceived norms often drive personal health behaviors, we do not know about this phenomenon in the context of antiretroviral therapy (ART) adherence. We conducted a... 相似文献
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The accuracy of self monitoring blood glucose meter systems in Kampala Uganda 总被引:2,自引:1,他引:1 下载免费PDF全文
Background
Many blood glucose self-monitoring systems are privately and publicly used by people in Uganda and technical and human errors may occur during their operation. Many patients were referred to Kololo polyclinic laboratory to have their blood glucose checked because the values obtained on the patients'' glucose meter systems did not tally with familiar clinical signs and symptoms. This prompted an experimental set up to check glucose meter systems using a larger number of patients.Objective
The objective was to collate the technical conditions and standing operational procedures of four common glucose meter systems; observe the time, ambient temperature and humidity at which the meter systems operate locally; and compare the performance of three meter systems A, B, and C with the Sensorex glucose meter system on a number of capillary blood samples.Setting
Kololo polyclinic laboratory-a privately run facility in Kampala, Uganda.Design
An experimental set up to compare four glucose meter systems.Methods
Instruction manuals of the four glucose monitoring systems were studied and used to familiarize with the meter operations. One hundred and fourteen capillary blood specimens were assayed for blood glucose. Blood glucose values were instantly read off the four randomly set meter systems A, B, C, and Sensorex, noting the time, ambient temperature and humidity. Results from meter systems A, B, and C were regressed against those of Sensorex using Epi-Info computer program.Results
Blood glucose concentration levels on meter system A tallied with those on Sensorex meter system. However, those on meter system B and C were significantly lower and different. Temperature and humidity adversely affected the analytical performance of meter systems B and C in the Kampala environ.Conclusion
Some of the blood glucose monitoring systems in Kampala, Uganda are poor performers and may lead to the mismanagement of patients. There is need for a system to ensure national quality control of blood glucose monitoring systems. 相似文献3.
Myaing M. Nyunt Vy K. Nguyen Richard Kajubi Liusheng Huang Joshua Ssebuliba Sylvia Kiconco Moses W. Mwima Jane Achan Francesca Aweeka Sunil Parikh Norah Mwebaza 《Antimicrobial agents and chemotherapy》2016,60(3):1274-1282
Artemether-lumefantrine is a first-line regimen for the treatment of uncomplicated malaria during the second and third trimesters of pregnancy. Previous studies have reported changes in the pharmacokinetics and clinical outcomes following treatment with artemether-lumefantrine in pregnant women compared to nonpregnant adults; however, the results are inconclusive. We conducted a study in rural Uganda to compare the pharmacokinetics of artemether-lumefantrine and the treatment responses between 30 pregnant women and 30 nonpregnant adults with uncomplicated Plasmodium falciparum malaria. All participants were uninfected with HIV, treated with a six-dose regimen of artemether-lumefantrine, and monitored clinically for 42 days. The pharmacokinetics of artemether, its metabolite dihydroartemisinin, and lumefantrine were evaluated for 21 days following treatment. We found no significant differences in the overall pharmacokinetics of artemether, dihydroartemisinin, or lumefantrine in a direct comparison of pregnant women to nonpregnant adults, except for a statistically significant but small difference in the terminal elimination half-lives of both dihydroartemisinin and lumefantrine. There were seven PCR-confirmed reinfections (5 pregnant and 2 nonpregnant participants). The observation of a shorter terminal half-life for lumefantrine may have contributed to a higher frequency of reinfection or a shorter posttreatment prophylactic period in pregnant women than in nonpregnant adults. While the comparable overall pharmacokinetic exposure is reassuring, studies are needed to further optimize antimalarial efficacy in pregnant women, particularly in high-transmission settings and because of emerging drug resistance. (This study is registered at ClinicalTrials.gov under registration no. .) NCT01717885相似文献
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Whole‐genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011 下载免费PDF全文
Denis K. Byarugaba Bernard Erima Monica Millard Hannah Kibuuka Luswa Lkwago Josephine Bwogi Derrick Mimbe Jocelyn B. Kiconco Titus Tugume Edison A. Mworozi Jasmine Turner Pamela P. Mckenzie Richard R. J. Webby Robert G. Webster Charlotte Foret Mariette F. Ducatez Rodney Coldren Fred Wabwire‐Mangen Scott Krauss 《Influenza and other respiratory viruses》2016,10(6):486-492
We report a whole‐genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitutions V106I and N248D in the neuraminidase proteins with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 to 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%–1.3% and 0.1%–1.6% for HA and NA genes, respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains. 相似文献
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