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排序方式: 共有176条查询结果,搜索用时 15 毫秒
1.
Kaira N Mahapatra GK Srivastava D Vaid L Taneja HC 《Journal of the Indian Society of Pedodontics and Preventive Dentistry》2002,20(2):49-50
A rare case of haemangioma of the oral cavity is presented. The lesion was treated using cryo-surgery. 相似文献
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Yuki Yokobori Minoru Toyoda Koichi Sakakura Kyoichi Kaira Yoshito Tsushima 《Acta oto-laryngologica》2015,135(5):494-499
Conclusion: The maximum standardized uptake value (SUVmax) of early oral squamous cell carcinoma (OSCC) may have a role as an imaging biomarker for assessment of malignant potential, including cell metabolism and angiogenesis. Objective: The usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been proven in various cancers, including OSCC. Moreover, in several carcinomas, the SUVmax of the tumor has been shown to correlate with the histological type, tumor stage, differentiation, and prognosis. Here, we investigated whether the SUVmax of early OSCC was associated with the biological features. Methods: Twenty-seven patients with newly diagnosed early OSCC who underwent preoperative FDG-PET and curative surgical resection were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), L-type amino acid transporter 1 (LAT1), CD98, microvessels (CD34), cell proliferation marker (Ki-67), and cell cycle regulator (p53). The correlation between SUVmax and clinicopathological findings or the expression level of these molecules was analyzed. Results: SUVmax of primary OSCC was significantly higher in patients with T2 stage. Moreover, patients whose tumors showed vascular invasion had a tendency to show higher SUVmax. A significant correlation was observed between SUVmax and the expression of LAT1 or microvessel density. 相似文献
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Tomohito Kuwako Hisao Imai Tomomi Masuda Yosuke Miura Kaori Seki Reiko Yoshino Kyoichi Kaira Mitsuyoshi Utsugi Kimihiro Shimizu Noriaki Sunaga Yoshio Tomizawa Shinichi Ishihara Takao Ishizuka Akira Mogi Takeshi Hisada Koichi Minato Atsushi Takise Ryusei Saito Masanobu Yamada 《Cancer chemotherapy and pharmacology》2015,76(4):761-769
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Hirotsugu Kenmotsu Yasuhisa Ohde Takehito Shukuya Hirofumi Eida Hiroaki Akamatsu Akira Ono Yukiko Nakamura Asuka Tsuya Kyoichi Kaira Tateaki Naito Haruyasu Murakami Toshiaki Takahashi Tomohiro Maniwa Mitsuhiro Isaka Masahiro Endo Haruhiko Kondo Nobuyuki Yamamoto 《Respiratory investigation》2012,50(4):157-161
BackgroundThe efficacy of postoperative adjuvant cisplatin (CDDP)-based chemotherapy, such as the combination of CDDP and vinorelbine (VNR), has been established for surgically resected non-small-cell lung cancer (NSCLC). However, the optimal treatment schedule and dosage for CDDP and VNR are unknown. We evaluated patient compliance with and the safety of adjuvant chemotherapy of CDDP at 80 mg/m2 administered on day 1 plus VNR at 25 mg/m2 administered on days 1 and 8, every 3 weeks.MethodsMedical records of 100 surgically resected NSCLC patients, treated with a combination of CDDP and VNR at the Shizuoka Cancer Center between February 2006 and October 2011, were retrospectively reviewed.ResultsEighty-three (83%) patients completed the planned 4 cycles of CDDP plus VNR and 59 (59%) received the planned doses. Sixty-eight percent of the patients experienced a decreased neutrophil count (grade 3/4 toxicity); 1%, a decreased platelet count; and 4%, febrile neutropenia. No treatment-related deaths were noted in this study. Univariate analysis of the factors influencing patient compliance with this adjuvant chemotherapy showed that neither patient characteristics nor surgical procedure was significantly associated.ConclusionsOur results indicated that adjuvant chemotherapy with CDDP at 80 mg/m2 administered on day 1 plus VNR at 25 mg/m2 administered on days 1 and 8, every 3 weeks, was feasible for surgically resected NSCLC cases. 相似文献
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Lukobo-Durrell M. Aladesanmi L. Suraratdecha C. Laube C. Grund J. Mohan D. Kabila M. Kaira F. Habel M. Hines J. Z. Mtonga H. Chituwo O. Conkling M. Chipimo P. J. Kachimba J. Toledo C. 《AIDS and behavior》2022,26(11):3597-3606
AIDS and Behavior - A well-documented barrier to voluntary medical male circumcision (VMMC) is financial loss due to the missed opportunity to work while undergoing and recovering from VMMC. We... 相似文献
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Kaira K Nakagawa K Ohde Y Okumura T Takahashi T Murakami H Endo M Kondo H Nakajima T Yamamoto N 《International journal of surgical pathology》2012,20(3):223-232
MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized expression (DP) group were 50 (39.7%), 35 (27.8%), and 41 (32.5%), respectively. Depolarized MUC1 expression was significantly associated with poor outcome and was closely correlated with glucose metabolism (Glut1), hypoxia (HIF-1α), angiogenesis (vascular endothelial growth factor and microvessel density), amino acid metabolism (LAT1), and EGFR expression. High-grade polarized MUC1 expression was associated with favorable prognosis and adenocarcinoma. Depolarized MUC1 expression was significantly associated with poor outcome. Glucose metabolism, hypoxia, angiogenesis, amino acid metabolism, and EGFR pathway may play an important role in the development of depolarized MUC1 expression. 相似文献
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K Kaira Y Sunose K Arakawa T Ogawa N Sunaga K Shimizu H Tominaga N Oriuchi H Itoh S Nagamori Y Kanai A Segawa M Furuya M Mori T Oyama I Takeyoshi 《British journal of cancer》2012,107(4):632-638
Background:The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression.Methods:A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53.Results:L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7% (55/97) of cases, respectively (P=0.568). The expression of LAT1 within pancreatic cancer cells was significantly associated with disease stage, tumour size, Ki-67, VEGF, CD34, p53 and CD98. L-type amino-acid transporter 1 expression was confirmed to be a significant prognostic factor for predicting poor outcome by multivariate analysis.Conclusion:L-type amino-acid transporter 1 expression is a promising pathological marker for the prediction of outcome in patients with pancreatic cancer. 相似文献