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排序方式: 共有195条查询结果,搜索用时 15 毫秒
1.
Siriporn C. Chattipakorn Savitree Thummasorn Jantira Sanit Nipon Chattipakorn 《老年心脏病学杂志》2014,11(2):151-157
Background Cilostazol is a type 3 phosphodiesterase inhibitor which has been previously demonstrated to prevent the occurrence of tachyarrhythmia and improve defibrillation efficacy. However, the mechanism for this beneficial effect is still unclear. Since cardiac mito-chondria have been shown to play a crucial role in fatal cardiac arrhythmias and that oxidative stress is one of the main contributors to arr-hythmia generation, we tested the effects of cilostazol on cardiac mitochondria under severe oxidative stress. Methods Mitochondria were isolated from rat hearts and treated with H2O2 to induce oxidative stress. Cilostazol, at various concentrations, was used to study its protective effects. Pharmacological interventions, including a mitochondrial permeability transition pore (mPTP) blocker, cyclosporine A (CsA), and an inner membrane anion channel (IMAC) blocker, 4'-chlorodiazepam (CDP), were used to investigate the mechanistic role of cilostazol on cardiac mitochondria. Cardiac mitochondrial reactive oxygen species (ROS) production, mitochondrial membrane potential change and mi-tochondrial swelling were determined as indicators of cardiac mitochondrial function. Results Cilostazol preserved cardiac mitochondrial function when exposed to oxidative stress by preventing mitochondrial depolarization, mitochondrial swelling, and decreasing ROS produc-tion. Conclusions Our findings suggest that cardioprotective effects of cilostazol reported previously could be due to its prevention of car-diac mitochondrial dysfunction caused by severe oxidative stress. 相似文献
2.
Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus 总被引:3,自引:0,他引:3
Pattamadilok S Lee BH Kumperasart S Yoshimatsu K Okumura M Nakamura I Araki K Khoprasert Y Dangsupa P Panlar P Jandrig B Krüger DH Klempa B Jäkel T Schmidt J Ulrich R Kariwa H Arikawa J 《The American journal of tropical medicine and hygiene》2006,75(5):994-1002
Phylogenetic investigations, sequence comparisons, and antigenic cross-reactivity studies confirmed the classification of Thailand virus (THAIV) as a distinct hantavirus species. The examination of sera from 402 rodents trapped in 19 provinces of Thailand revealed that five greater bandicoot rats (Bandicota indica) and one lesser bandicoot rat (B. savilei) from four provinces were focus reduction neutralization test (FRNT) antibody-positive for THAIV. One of 260 patients from Surin province in Thailand (initially suspected of having contracted leptospirosis, but found to be negative) showed symptoms compatible with hemorrhagic fever with renal syndrome (HFRS). The serum of this patient showed high titers of hantavirus-reactive IgM and IgG. FRNT investigations confirmed virus-neutralizing antibodies against THAIV. These observations suggest that THAIV or THAI-like viruses occur throughout Indochina and may represent an additional causative agent of HFRS. 相似文献
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Sanitätsrat Dr. Kurt Müller 《Archives of orthopaedic and trauma surgery》1919,17(2-4):213-287
Ohne Zusammenfassung
Mit 6 Abbildungen im Text. 相似文献
5.
Sangob Sanit Kabkaew L. Sukontason Pongruk Sribanditmongkol Tunwadee Klong-klaew Chutharat Samerjai Narin Sontigun Kwankamol Limsopatham Kom Sukontason 《Parasitology research》2012,111(6):2235-2240
Flies of the genus Hypopygiopsis are forensically important, as their larvae are found to associate with human corpses. In this study, the ultrastructure of larvae and puparia of Hypopygiopsis tumrasvini Kurahashi is presented using scanning electron microscopy (SEM). The larvae are vermiform-shaped, creamy white, and have a smooth integument. The pseudocephalon of larvae bears sensory structures, i.e., antenna, maxillary palpus, and ventral organ. Two tufts of fresh outgrowths (or cerri) were observed along the dorsal margin of the mouth opening of the first instar; whereas a strong mouth hook was apparent in the second and third instars. Keilin??s organ, the sensory structure, was noticeable on the ventral surface of the thoracic segments in all instars. In the second and third instars, six conspicuous tubercles were present along the peripheral rims of the last abdominal segment. The puparia were relatively large, measuring 7.77?C9.51?mm in length and 3.10?C3.97?mm in width. At the latero-dorsal edge of the first abdominal segment, a cluster of ??125 bubble membranes was seen in young puparia; whereas a minute pupal respiratory horn was observed in old one. An SEM image revealed antler-like projections lined within a chamber of a broken pupal respiratory horn. Comparison on number of the bubble membranes of the other blow fly species was shown and the role of pupal respiratory horn compared with other dipterans was discussed. 相似文献
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Ohne Zusammenfassung 相似文献
8.
Sanitätsrat Dr. R. Sondermann 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1948,148(3-4):331-337
Ohne Zusammenfassung 相似文献
9.
Sanitätsrath Dr. Boegehold 《Archives of dermatological research》1901,55(3):387-393
Ohne ZusammenfassungQuibusdam simulac venere sunt usi eo ipso die caries erumpit; nonnulli post coitum non corripiuntur carie nisi post 30 aut 40 dies. Hieronymus Capivaccius. 相似文献
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