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1.
Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study 下载免费PDF全文
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Ivar Reinvang Astri J. Lundervold Helge Rootwelt Eike Wehling Thomas Espeseth 《Neuroscience letters》2009
Cholinergic influences on attention are well documented and recent evidence indicates that genetic variation in the α4β2 nicotinic receptor affects attentional networks of the brain. Several behavioral and electrophysiological studies have shown that a common polymorphism in the CHRNA4 gene (rs1044396) affects aspects of visual and auditory attentional processing. We examined genetic effects on neuropsychological measures of memory and attention in an adult life-span sample (N = 488). TT homozygotes perform speed and attention tasks more slowly than TC or CC allele carriers, with stronger effects on complex attention tasks in participant 70–79 years of age. There are no parallel effects on memory function. The results are consistent with clinical studies indicating that reduction in nicotinic receptor efficiency affects attention and speed, but not memory. Both normal age-related changes in receptor function and incipient pathology may have contributed to the results. 相似文献
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Stein Andersson Maj-Britt Posserud Astri J. Lundervold 《Research in autism spectrum disorders》2013,7(7):815-823
Event-related potentials (ERP) studies have offered diverging results in characterizing the basic nature of abnormal sensory processing and discrimination in autism spectrum disorders (ASDs). In the present study we report duration mismatch negativity (MMN) and later ERP components (P3a and P3b) derived from auditory odd-ball paradigms in a homogenous sample of cognitively high functioning male adolescents with ASD. We find significantly reduced frontal and temporal MMN amplitudes and no differences in P3a or P3b amplitudes or latencies compared to controls. These findings are in contrast to recent studies reporting enhanced ERP amplitudes to auditory stimuli, and are more in support of a weakened automatic auditory sensory processing as being central to the abnormal auditory behavioral responses commonly encountered in ASD. 相似文献
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E Macdonald BT Heier K Nygård T Stalheim KS Cudjoe T Skjerdal AL Wester BA Lindstedt TL Stavnes L Vold 《Emerging infectious diseases》2012,18(9):1496-1499
In 2011, an outbreak of illness caused by Yersinia enterocolitica O:9 in Norway was linked to ready-to-eat salad mix, an unusual vehicle for this pathogen. The outbreak illustrates the need to characterize isolates of this organism, and reinforces the need for international traceback mechanisms for fresh produce. 相似文献
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Book Review: The past and present of leprosy: archaeological, historical, palaeopathological and clinical approaches. Proceedings of the International Congress on the Evolution and Palaeoepidemiology of the Infectious Diseases 3 (ICEPID), University of Bradford 26–31 July 1999 下载免费PDF全文
Astri Andresen 《Medical history》2004,48(2):280-282
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Kirsten I Stordal Astri J Lundervold Arnstein Mykletun Arve Asbj?rnsen Eva Biringer Jens Egeland Asa Hammar Nils Inge Landr? Atle Roness Bj?rn Rishovd Rund Kjetil Sundet Anders Lund 《The world journal of biological psychiatry》2005,6(1):36-44
Major depression is associated with impairment of cognitive functions, and especially higher-order cognitive processes referred to as executive functions (EF). Whether this is a general finding is unclear. Patients without EF impairment may have different treatment needs than patients with EF impairment, and will probably have a better everyday functioning. Thus, it is important to identify the prevalence and characteristics of depressed patients without EF impairment. Forty-three patients with recurrent major depressive disorder (19-51 years) and 50 healthy controls were included in the study. The subjects were assessed with neuropsychological tests selected to measure central areas of EF, and screened on clinical and demographic variables. Within the depressed group, a total of 56% were defined as EF unimpaired. These patients were characterised by higher intellectual abilities and fewer depression episodes than the subgroup of patients with EF impairment. The subgroups were similar in age at debut of illness, severity of depression, general psychopathology and global level of functioning. In conclusion, about half of patients with recurrent major depression have normal EF. Since cognitive impairment and depressive symptomatology seem to be distinct dimensions, a neuropsychological investigation could help to ensure optimal treatment in patients with recurrent major depression. 相似文献