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1.
Carinci F Cassano L Farina A Pelucchi S Calearo C Modugno V Nielsen I Api P Pastore A 《The Journal of craniofacial surgery》2001,12(5):438-443
A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that an association of neck dissection plus chemoradiotherapy can be useful in the event of unresectable advanced carcinomas. 相似文献
2.
Wisit Kaewput Charat Thongprayoon Tananchai Petnak Api Chewcharat Boonphiphop Boonpheng Tarun Bathini Saraschandra Vallabhajosyula Wisit Cheungpasitporn 《The American journal of the medical sciences》2021,361(1):69-74
BackgroundThis study aimed to assess inpatient prevalence, characteristics, outcomes, and resource utilization of hospitalization for methanol intoxication in the United States.Materials and MethodsA total of 603 hospitalized patients with a primary diagnosis of methanol intoxication from 2003 to 2014 were identified in the National Inpatient Sample database. The inpatient prevalence, clinical characteristics, treatments, outcomes, resource utilization, were investigated. Multivariable logistic regression was performed to identify factors independently associated with in-hospital mortality.ResultsThe overall inpatient prevalence of methanol intoxication among hospitalized patients was 6.4 cases per 1,000,000 admissions in the United States. The mean age was 38±18 (range 0–86) years. 44% used methanol for suicidal attempts. 20% of admissions required mechanical ventilation, and 40% required renal replacement therapy. The three most common complications were metabolic acidosis (44%), hypokalemia (18%), and visual impairment or optic neuritis (8%). The three most common end-organ failures were renal failure (22%), respiratory failure (21%), and neurological failure (17%). 6.5% died in the hospital. Factors associated with increased in-hospital mortality included alcohol drinking, hypernatremia, renal failure, respiratory failure, circulatory failure, and neurological failure. The mean length of hospital stay was 4.0 days. The mean hospitalization cost per patient was $43,222ConclusionThe inpatient prevalence of methanol intoxication in the United States was 6.4 cases per 1,000,000 admissions. The risk of in-hospital mortality mainly depended on the number of end-organ failures. 相似文献
3.
Ultrasonographic appearance of cervical pregnancy following successful treatment with methotrexate. 总被引:1,自引:0,他引:1
O Api O Unal M Api B Ergin N Alkan B Kars C Turan 《Ultrasound in obstetrics & gynecology》2006,28(6):845-847
We report a case of cervical ectopic pregnancy successfully treated with systemic methotrexate. Conservative management with single-dose methotrexate was undertaken, but owing to the failure of human chorionic gonadotropin (hCG) levels to fall by 15% by day 7 and the persistence of fetal cardiac activity, two further doses of methotrexate were required. The patient's hCG levels were monitored, and repeat transvaginal ultrasonography was performed until complete resolution of the pregnancy by spontaneous miscarriage. We describe the ultrasonographic findings, which showed that the sac size increased despite treatment. 相似文献
4.
Olus Api H. Nihan Demır Murat Api Ismet Tamer Ekrem Orbay Orhan Unal 《Archives of gynecology and obstetrics》2009,280(4):553-558
Objective The value of genetic sonogram is controversial in low-risk population. The aim of our study was to compare the anxiety levels
among women with high risk and low risk for fetal chromosomal/structural defects.
Materials and methods A total of 115 consecutive pregnant women were included. The anxiety levels were assessed by the use of Turkish version of
the standardized state-trait-anxiety-inventory. Before and after genetic sonogram, state and trait-anxiety was measured.
Results The mean state anxiety score before genetic sonogram was statistically, significantly higher than the mean score after the
examination. Before genetic sonogram, the mean state-anxiety score of the women with high risk for fetal chromosomal/structural
defects was significantly higher than the mean score of women with low risk. Following genetic sonogram, although the anxiety
scores decreased, the scores of women with high risk still remained significantly higher than the scores of women with low
risk and the anxiety scores significantly further increased among women with a positive minor or major ultrasound finding.
Conclusion Genetic sonogram presents an anxiety-inducing situation for the parents-to-be. The level of experienced anxiety was found
to be proportional to the level of the perceived risk. Women with low risk for chromosomal/structural defects experienced
lower anxiety than women with high risk. Following the examination, women with a negative result were found to have a significant
reduction of anxiety and emotional relief whereas a positive test result led to a further increase in anxiety scores. 相似文献
5.
6.
J C Alvarez López G Solís J Gónzalez de Zárate Api?aniz J I Gómez Herreras J García Casta?o R Mu?oz Fernández 《Revista espa?ola de anestesiología y reanimación》1991,38(2):115-117
A patient with a hepatic hydatid cyst with fistula formation to inferior vena cava is reported. To carry out the resection, the cyst was isolated from systemic circulation by means of cardiopulmonary bypass. Inferior vena cava was cannulated through the right atrium until the implantation area of the cyst (above the hepatic veins) was surpassed. Bypass was carried out in 25 minutes by means of cannulation of the ascending aorta, without clamping the aorta, myocardial protection or hypothermia. Postoperative analgesia was achieved with a lumbar epidural catheter. Measures to prevent anaphylactic shock are recommended, an anesthetic technique based on the prevention of hypersensitivity reactions and a careful surgical technique to prevent hydatid dissemination. 相似文献
7.
Yazici AC Tamer L Ikizoglu G Kaya TI Api H Yildirim H Adiguzel A 《Photodermatology, photoimmunology & photomedicine》2006,22(4):208-210
PURPOSE: Rosacea might be related to an increased activity of reactive oxygen species (ROS) and deficient function of the antioxidant system. Glutathione S-transferases (GSTs) play a primer role in cellular defense against electrophilic chemical species and radical oxygen species. We hypothesized that increased ROS activity or decreased antioxidant potential, possibly induced by GST gene polymorphism, might have a pathogenic role in rosacea. METHODS: The study group consisted of 45 patients with rosacea and 100 control subjects. DNA samples were isolated from blood samples using high pure polymerase chain reaction (PCR) Template preparation Kit. The GSTM1, GSTT1, and P1 polymorphisms were detected using a real-time PCR and fluorescence resonance energy transfer with a Light-Cycler Instrument. Associations between specific genotypes and the development of rosacea were examined using logistic regression analyses to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: GSTM1 and GSTT1 null genotypes were found to be statistically different from control (P=0.005, P=0.009, respectively), and associated with an increased risk of rosacea (OR [95% CI]: 2.84 [1.37-5.89]; OR [95% CI]: 2.68 [1.27-5.67], respectively). There was a statistically significant relationship between both null combination of the GSTM1 and GSTT1 genotype polymorphisms and rosacea (P=0.003, OR [95% CI]: 4.18 [1.57-11.13]). There were no statistically significant differences between patient and control groups for the GSTP1 Ile/Ile, Ile/Val, and Val/Val genotypes (P>0.05). CONCLUSION: We demonstrated a significant association between the GSTT1 and/or GSTM1 null genotypes and rosacea. However, the potential role of GSTs as markers of susceptibility to rosacea needs further studies in larger patient groups. 相似文献
8.
The changes in expression of ICAM-3, Ki-67, PCNA,and CD31 in psoriatic lesions before and after methotrexate treatment 总被引:2,自引:0,他引:2
Yazici AC Tursen U Apa DD Ikizoglu G Api H Baz K Tasdelen B 《Archives of dermatological research》2005,297(6):249-255
Although the effectiveness of methotrexate (MTX) in the treatment of psoriasis is very well established, the mechanism of
action is poorly understood. It was suggested that the therapeutic effect of MTX in psoriasis might be mediated by inhibition
of adhesion molecule expression. The aim of our study was to investigate the different effects of MTX treatment on cell proliferation,
inflammatory infiltrate, adhesion molecules, and angiogenesis in psoriasis, and to clarify the mechanism by which MTX exerts
its therapeutic effects. Clinical response, the morpho–phenotypic changes, epidermal thickness, and mitosis count were analyzed
and the expression of CD31 and ICAM-3, proliferative markers such as Ki-67, PCNA, were evaluated by immunohistochemical techniques
in lesional psoriatic epidermis, before and after the treatment with MTX in ten patients. In posttreatment biopsies a decrease
in the degree of epidermal hyperplasia and a significant reduction in the severity of the inflammatory infiltrate (P<0.05) were observed. In addition, CD31 and ICAM-3 expression was significantly decreased on dermal cellular infiltrate, (respectively;
P<0.05, P<0.01). Ki67 and PCNA expression were suppressed concurrently in about 90% of cases (P<0.01). We suggest that MTX may have an inhibitory effect on an initial integral component of the pathways that lead to psoriasis.
Immunopharmacologic intervention in adhesion event has the potential to improve psoriasis. Inhibition of revascularization
may be another mechanism of action of MTX. 相似文献
9.
Anne Marie Api 《Food and chemical toxicology》2004,42(2):307-311
Phenoxyethyl isobutyrate (PEIB) is a fragrance and food ingredient that has been granted GRAS status and approved by the FDA for food use. The present studies investigated the dermal absorption parameters and subchronic toxicity of PEIB. For the absorption, distribution and elimination study, Sprague-Dawley rats received a dermal application of 2-[ring U 14C]-PEIB under occlusion for 6 h. PEIB was diluted in diethyl phthalate (DEP) to administer, a total application volume of 2 ml/kg, concentrations of 0.5, 5 and 50% ( congruent with 10, 100 and 1000 mg PEIB/kgBW). Approximately 61-69% of the applied dose was recovered from the dressing and skin surface washing procedure performed after 6-h exposure. By 72 h post dose, systemic elimination of radioactivity was congruent with 18 to 19% of the absorbed dose via the urine with small amounts also found in the feces (<1.0%). Terminal (72 h) tissue analysis showed that 0.35-0.72% of the applied dose of radioactivity was retained in the carcass with low levels (=0.03%) measured also in the liver, kidney and gastrointestinal tract. Plasma levels increased in a dose-related manner, with concentrations equal to 0.02, 0.2 and 2.0 microg equiv/ml from low to high dose, respectively. The total recovery for these studies ranged from 92.2 to 96.2% of the dermally applied radioisotope. In a 13-week subchronic rat toxicity study, daily dermal applications of PEIB were made under occlusion for 6 h. All groups were dosed at a constant 2 ml/kgBW volume of PEIB in the DEP vehicle at concentrations calculated to administer 0, 100, 300 or 1000 mg PEIB/kgBW/day. Clinical observations, assessments of skin irritation, hematology, and blood chemistry, necropsy, and gross and histopathologic evaluation of tissues demonstrated no treatment-related effects. The local skin irritation and systemic toxicity no-observed-effect-levels (NOELs) for PEIB in this study were determined to be >1000 mg/kgBW/day. 相似文献
10.
C S Letizia J Cocchiara A Lapczynski J Lalko A M Api 《Food and chemical toxicology》2005,43(6):925-943
A toxicologic and dermatologic review of cinnamic acid when used as a fragrance ingredient is presented. 相似文献