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Objective To explore the characteristics and risk factors of type 2 diabetes mellitus (T2DM) onset in pedigrees. Methods A total of 865 subjects were screened and diagnosed by oral glucose tolerance test (OGTT) based on American Diabetes Association (ADA) criteria. Type 1 diabetes mellitus (T1DM) , maturity onset diabetes of the young (MODY) and chondriosome diabetes were excluded by clinical features and laboratory test of insulin and autoantibodies including glutamic acid decarboxylase antibody, insular cellular antibody and insulin autoantibody. A total of 182 pedigrees of T2DM were obtained. Results No gender difference was found in the prevalence of T2DM (42. 59% in male and 48. 18% in female respectively, P >0. 05) , nor was the newly diagnosed rate(9. 89% in male and 11. 82%in female, P > 0. 05). The onset age was (63. 3 ± 12. 4) years old in the first generation [(64. 4 ± 12. 5)years in male and (62. 3 ± 10. 3) years in female] , (47. 1 ± 8. 7) years old in the second generation [(48. 2 ±9. 3)years in male and (46. 1 ± 8. 1) years in female] , (29. 6 ± 10. 2) years old in the third generation [(28. 9 ±9. 5)years in male and (30. 0 ± 10. 4)years in female]. Compared with normal glucose tolerance (NGT) subjects , newly diagnosed T2DM and impaired glucose regulation (IGR) subjects had higher prevalence of hypertension, hyperlipidemia and smoking but less physical activities. Statistical differences were shown in body weight five years before diagnosis, one years before diagnosis and at diagnosis in newly diagnosed T2DM[(68. 4 ±12. 4)kg, (69. 5 ± 11. 0)kg and (69. 1 ±9. 6)kg] and IGR[(66. 1 ±10.7)kg, (65.9 ± 10.7) kg and(65.7 ± 10.4) kg] , when compared with NGT [(61.0 ± 10.2) kg,(59. 5 ±11.0) kg and (60. 1 ± 10. 4) kg, all P < 0. 05] . The same results were obtained with waist circumference and waist-hip ratio [(4. 1 ± 12. 5) cm and 0. 92 ± 0. 36 in newly diagnosed T2DM while (89. 1 ± 10. 7) cm and 0. 90 ± 0. 64 in IGR] , when compared with NGT[(82. 5 ± 10. 1) cm and 0. 82 ±0. 25] , all P <0. 05. Conclusions No gender difference was found in the onset characteristics of T2DM.High prevalence of obesity, hypertension, hyperlipidemia and smoking with less physical activities were associated with T2DM. 相似文献
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研究人员对双氟脱氧胞苷与长春瑞宾 (vinorelbine,VRB)联用作为紫杉烷类加铂类治疗无效或复发的NSCLC的二线治疗方案进行了二期临床研究。选择了40例晚期 (Ⅲ/Ⅳ期 )NSCLC病例进行研究 ,所有病例均无器官功能损害 ,体力状态分级≤2,中性粒细胞≥1.5×109/L,预期寿命≥3个月 ,有一个以上的转移灶 ,均已使用过紫杉烷类 (紫杉醇/紫杉特尔 )加铂类 (顺铂/卡铂 )治疗 ,其中16例患者对一线治疗无效 ,24例患者紫杉烷类加铂类治疗缓解后复发。化疗方案为 :VRB25mg/m2 加入100ml生理盐水… 相似文献
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目的对《肿瘤药学》杂志2011年载文的引文进行分析,以了解本刊的引文情况及文献利用能力。方法利用Excel软件,对引文量、引文语种及类型、引文时间分布与普赖斯指数、自引率等进行定量分析。结果 131篇论文中,共有引文1670条,篇均引文12.7条,其中,英文1048条,占62.8%,中文621条,占37.2%;期刊为最主要的情报源,占94.2%;84.1%的引文在文章发表的前10年内,普赖斯指数为53.9%;自引率为2.6%。结论《肿瘤药学》杂志以中、英文期刊为主要情报源,近10年的文献可基本满足引文需要。 相似文献
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头孢菌素类药物过敏反应分析 总被引:10,自引:0,他引:10
头孢菌素类药物过敏反应分析丁惠萍黄平(湖南省肿瘤医院410006)β-内酰胺类抗生素的过敏反应是临床上常见的不良反应,其中以青霉素类最为严重,发生率为0.7%~10%,头孢菌素类过敏反应的发生率约为青霉素的10%~30%[1],与青霉素呈现不完全的交... 相似文献
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《中国药房》1~5卷引文分析及评价 总被引:4,自引:0,他引:4
《中国药房》1~5卷引文分析及评价湖南省肿瘤医院(410006)丁惠萍引文分析是利用文献计量学方法对科学论文的引用文献(引文,即参考文献)进行统计、分析和评价的方法。近年来一些学科应用这一方法进行分析研究,收到良好效果。本文通过对《中国药房》1990... 相似文献
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湖南省肿瘤医院于1995年对住院部、门诊收费及药房、药库采用计算机网络管理,提高了管理水平,现将药品管理系统介绍如下。一、系统运行环境软件系统采用微机上最新的数据库Fox-p]forDOS编程,软件环境为MS-DOS6.2,汉字环境为UCDOS5.0,硬件环境为386及以上档原装机或兼容机。二、主控模块及功能整个模块由控制模块和功能模块组成,控制模块负责功能模块,功能模块完成具体的信息处理,采用统一的人机交换界面和操作过程,所有的功能选择均以下拉式菜单来实现,既可用于药库药品管理,亦可用于药房药品管理。对药库药品计划采… 相似文献
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血管紧张素转化酶抑制剂(ACEI)广泛用于心脏移植 术后冠状动脉疾病的预防性治疗。大多数患者在使用ACEI治疗后,血清钠离子浓度无明显变化,但也有少数患者发生有症状的严重的低钠血症。以下是1例 相似文献
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近年来,山莨菪碱(654-2)在抗肿瘤治疗中的应用屡有报道,现概述如下。1 抗呕吐作用 许多抗癌药物都可以引起不同程度的消化道反应,如食欲减退、恶心、呕吐等,常用灭吐灵、地塞米松、氯丙嗪、异丙嗪等治疗。常瑛等应用654-2、异丙嗪双足三里穴注射或肌肉注射对抗化疗所致呕 相似文献
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