全文获取类型
收费全文 | 15731篇 |
免费 | 1228篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 129篇 |
儿科学 | 708篇 |
妇产科学 | 447篇 |
基础医学 | 2171篇 |
口腔科学 | 159篇 |
临床医学 | 2237篇 |
内科学 | 3013篇 |
皮肤病学 | 138篇 |
神经病学 | 1347篇 |
特种医学 | 345篇 |
外国民族医学 | 1篇 |
外科学 | 1616篇 |
综合类 | 220篇 |
一般理论 | 16篇 |
预防医学 | 1865篇 |
眼科学 | 230篇 |
药学 | 811篇 |
中国医学 | 20篇 |
肿瘤学 | 1524篇 |
出版年
2023年 | 108篇 |
2022年 | 85篇 |
2021年 | 348篇 |
2020年 | 278篇 |
2019年 | 440篇 |
2018年 | 427篇 |
2017年 | 352篇 |
2016年 | 379篇 |
2015年 | 389篇 |
2014年 | 538篇 |
2013年 | 831篇 |
2012年 | 1223篇 |
2011年 | 1287篇 |
2010年 | 702篇 |
2009年 | 662篇 |
2008年 | 1079篇 |
2007年 | 1129篇 |
2006年 | 1062篇 |
2005年 | 1052篇 |
2004年 | 933篇 |
2003年 | 836篇 |
2002年 | 806篇 |
2001年 | 247篇 |
2000年 | 180篇 |
1999年 | 177篇 |
1998年 | 116篇 |
1997年 | 87篇 |
1996年 | 76篇 |
1995年 | 112篇 |
1994年 | 72篇 |
1993年 | 68篇 |
1992年 | 106篇 |
1991年 | 87篇 |
1990年 | 65篇 |
1989年 | 81篇 |
1988年 | 61篇 |
1987年 | 76篇 |
1986年 | 56篇 |
1985年 | 44篇 |
1984年 | 44篇 |
1983年 | 40篇 |
1982年 | 39篇 |
1981年 | 39篇 |
1980年 | 23篇 |
1979年 | 21篇 |
1978年 | 22篇 |
1977年 | 16篇 |
1976年 | 22篇 |
1974年 | 14篇 |
1972年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Laurien J. Zeverijn Eleonora J. Looze Subotheni Thavaneswaran J. Maxime van Berge Henegouwen Robert J. Simes Louisa R. Hoes Katrin M. Sjoquist Hanneke van der Wijngaart Lucille Sebastian Birgit S. Geurts Chee K. Lee Gijsbrecht F. de Wit David Espinoza Paul Roepman Frank P. Lin Anne M. L. Jansen Wendy W. J. de Leng Vincent van der Noort Lindsay V. M. Leek Filip Y. F. L. de Vos Carla M. L. van Herpen Hans Gelderblom Henk M. W. Verheul David M. Thomas Emile E. Voest 《International journal of cancer. Journal international du cancer》2023,153(7):1413-1422
The Dutch Drug Rediscovery Protocol (DRUP) and the Australian Cancer Molecular Screening and Therapeutic (MoST) Program are similar nonrandomized, multidrug, pan-cancer trial platforms that aim to identify signals of clinical activity of molecularly matched targeted therapies or immunotherapies outside their approved indications. Here, we report results for advanced or metastatic cancer patients with tumors harboring cyclin D-CDK4/6 pathway alterations treated with CDK4/6 inhibitors palbociclib or ribociclib. We included adult patients that had therapy-refractory solid malignancies with the following alterations: amplifications of CDK4, CDK6, CCND1, CCND2 or CCND3, or complete loss of CDKN2A or SMARCA4. Within MoST, all patients were treated with palbociclib, whereas in DRUP, palbociclib and ribociclib were assigned to different cohorts (defined by tumor type and alteration). The primary endpoint for this combined analysis was clinical benefit, defined as confirmed objective response or stable disease ≥16 weeks. We treated 139 patients with a broad variety of tumor types; 116 with palbociclib and 23 with ribociclib. In 112 evaluable patients, the objective response rate was 0% and clinical benefit rate at 16 weeks was 15%. Median progression-free survival was 4 months (95% CI: 3-5 months), and median overall survival 5 months (95% CI: 4-6 months). In conclusion, only limited clinical activity of palbociclib and ribociclib monotherapy in patients with pretreated cancers harboring cyclin D-CDK4/6 pathway alterations was observed. Our findings indicate that monotherapy use of palbociclib or ribociclib is not recommended and that merging data of two similar precision oncology trials is feasible. 相似文献
2.
In clinical and epidemiological studies, there is a growing interest in studying the heterogeneity among patients based on longitudinal characteristics to identify subtypes of the study population. Compared to clustering a single longitudinal marker, simultaneously clustering multiple longitudinal markers allow additional information to be incorporated into the clustering process, which reveals co-existing longitudinal patterns and generates deeper biological insight. In the current study, we propose a Bayesian consensus clustering (BCC) model for multivariate longitudinal data. Instead of arriving at a single overall clustering, the proposed model allows each marker to follow marker-specific local clustering and these local clusterings are aggregated to find a global (consensus) clustering. To estimate the posterior distribution of model parameters, a Gibbs sampling algorithm is proposed. We apply our proposed model to the primary biliary cirrhosis study to identify patient subtypes that may be associated with their prognosis. We also perform simulation studies to compare the clustering performance between the proposed model and existing models under several scenarios. The results demonstrate that the proposed BCC model serves as a useful tool for clustering multivariate longitudinal data. 相似文献
3.
4.
5.
Hajrunisa Cubro Karl A. Nath Sonja Suvakov Oscar Garcia-Valencia Santosh Parashuram Wendy M. White Tracey L. Weissgerber Meryl C. Nath Natasa M. Milic Fernando Sontag Livius V. d’Uscio Yi Zhu James L. Kirkland Tamar Tchkonia Mariam P. Alexander Reade A. Quinton Zvonimir S. Katusic Joseph P. Grande Vesna D. Garovic 《Kidney international》2021,99(3):646-656
6.
Stephanie H. Ameis John D. Haltigan Rachael E. Lyon Amanda Sawyer Pat Mirenda Connor M. Kerns Isabel M. Smith Tracy Vaillancourt Joanne Volden Charlotte Waddell Lonnie Zwaigenbaum Teresa Bennett Eric Duku Mayada Elsabbagh Stelios Georgiades Wendy J. Ungar Anat Zaidman-Zait Meng-Chuan Lai Peter Szatmari for the Pathways in ASD Study Team 《Journal of child psychology and psychiatry, and allied disciplines》2022,63(5):553-562
7.
8.
9.
10.
Wendy Moyle Cindy Jones Toni Dwan Tamara Ownsworth Billy Sung 《Aging & mental health》2019,23(12):1643-1650
AbstractObjectives: To explore the acceptability of telepresence robots in dementia care from the perspectives of people with dementia, family carers, and health professionals/trainees, and investigate the utility of a social presence assessment tool, the Modified-Temple Presence Inventory (Modified-TPI), for people with dementia.Method: A mixed-methods pilot study conducted in a social robotics laboratory. Three participant groups (n?=?22) – dyads of people with dementia and their carers (n?=?5 respectively), and health professionals/trainees (n?=?12) – participated in individual one-off intervention sessions with the telepresence robot, Giraff, with follow-up interviews. Sessions covered how to use Giraff, followed by interactive practice in making a video-call involving conversation and manoeuvring of Giraff. Participants with dementia experienced receiving a call made by their carer; healthcare professionals/trainees experienced making and receiving a call. Outcomes of interest were sense of presence [Modified-TPI], affective response (International Positive and Negative Affect Schedule [I-PANAS-S]; Observable Displays of Affect Scale [ODAS]), and attitudes and reactions to Giraff (semi-structured interviews).Results: Participants reported a sense of authenticity and social connection through the experience. They indicated positive social presence through Giraff, and significantly higher positive (mean score 18.77; ±4.00) than negative affect (mean score 8.05; ±1.76) on the I-PANAS-SF, and on the facial display subscale of the ODAS (positive – mean score 15.50; ±3.51 versus negative – mean score 4.00; ±0.00).Conclusion: Telepresence has potential use in situations where people with dementia require social connection. Studies with larger sample sizes, varied characteristics, and cost-effectiveness analysis are needed to inform the application of telepresence in healthcare practice. 相似文献