全文获取类型
收费全文 | 19751篇 |
免费 | 1795篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 104篇 |
儿科学 | 630篇 |
妇产科学 | 542篇 |
基础医学 | 2869篇 |
口腔科学 | 290篇 |
临床医学 | 2570篇 |
内科学 | 3844篇 |
皮肤病学 | 439篇 |
神经病学 | 1896篇 |
特种医学 | 781篇 |
外科学 | 2499篇 |
综合类 | 607篇 |
一般理论 | 15篇 |
预防医学 | 1649篇 |
眼科学 | 256篇 |
药学 | 1285篇 |
中国医学 | 15篇 |
肿瘤学 | 1285篇 |
出版年
2021年 | 280篇 |
2020年 | 215篇 |
2019年 | 321篇 |
2018年 | 370篇 |
2017年 | 300篇 |
2016年 | 283篇 |
2015年 | 313篇 |
2014年 | 454篇 |
2013年 | 670篇 |
2012年 | 937篇 |
2011年 | 903篇 |
2010年 | 518篇 |
2009年 | 501篇 |
2008年 | 869篇 |
2007年 | 899篇 |
2006年 | 906篇 |
2005年 | 820篇 |
2004年 | 838篇 |
2003年 | 790篇 |
2002年 | 675篇 |
2001年 | 678篇 |
2000年 | 716篇 |
1999年 | 617篇 |
1998年 | 218篇 |
1997年 | 182篇 |
1996年 | 192篇 |
1995年 | 200篇 |
1994年 | 190篇 |
1993年 | 182篇 |
1992年 | 468篇 |
1991年 | 451篇 |
1990年 | 418篇 |
1989年 | 380篇 |
1988年 | 362篇 |
1987年 | 403篇 |
1986年 | 364篇 |
1985年 | 371篇 |
1984年 | 293篇 |
1983年 | 254篇 |
1982年 | 164篇 |
1981年 | 162篇 |
1980年 | 134篇 |
1979年 | 242篇 |
1978年 | 200篇 |
1977年 | 144篇 |
1975年 | 116篇 |
1974年 | 166篇 |
1973年 | 161篇 |
1972年 | 153篇 |
1971年 | 133篇 |
排序方式: 共有10000条查询结果,搜索用时 93 毫秒
1.
Tran Thi Hien Ines Ambite Murphy Lam Yim Wan Michele Cavalera Parisa Esmaeili Arunima Chaudhuri Samudra Sabari Marek Babjuk Catharina Svanborg 《International journal of cancer. Journal international du cancer》2023,153(3):584-599
Bladder cancer is common and one of the most costly cancer forms, due to a lack of curative therapies. Recently, clinical safety and efficacy of the alpha1-oleate complex was demonstrated in a placebo-controlled study of nonmuscle invasive bladder cancer. Our study investigated if long-term therapeutic efficacy is improved by repeated treatment cycles and by combining alpha1-oleate with low-dose chemotherapy. Rapidly growing bladder tumors were treated by intravesical instillation of alpha1-oleate, Epirubicin or Mitomycin C alone or in combination. One treatment cycle arrested tumor growth, with a protective effect lasting at least 4 weeks in mice receiving 8.5 mM of alpha1-oleate alone or 1.7 mM of alpha-oleate combined with Epirubicin or Mitomycin C. Repeated treatment cycles extended protection, defined by a lack of bladder pathology and a virtual absence of bladder cancer-specific gene expression. Synergy with Epirubicin was detected at the lower alpha1-oleate concentration and in vitro, alpha1-oleate was shown to enhance the uptake and nuclear translocation of Epirubicin, by tumor cells. Effects at the chromatin level affecting cell proliferation were further suggested by reduced BrdU incorporation. In addition, alpha1-oleate triggered DNA fragmentation, defined by the TUNEL assay. The results suggest that bladder cancer development may be prevented long-term in the murine model, by alpha1-oleate alone or in combination with low-dose Epirubicin. In addition, the combination of alpha1-oleate and Epirubicin reduced the size of established tumors. Exploring these potent preventive and therapeutic effects will be of immediate interest in patients with bladder cancer. 相似文献
2.
3.
4.
5.
6.
7.
8.
Harinakshi Sanikini David C. Muller Marisa Sophiea Sabina Rinaldi Antonio Agudo Eric J. Duell Elisabete Weiderpass Kim Overvad Anne Tjønneland Jytte Halkjær Marie-Christine Boutron-Ruault Franck Carbonnel Iris Cervenka Heiner Boeing Rudolf Kaaks Tilman Kühn Antonia Trichopoulou Georgia Martimianaki Anna Karakatsani Valeria Pala Domenico Palli Amalia Mattiello Rosario Tumino Carlotta Sacerdote Guri Skeie Charlotta Rylander María-Dolores Chirlaque López Maria-Jose Sánchez Eva Ardanaz Sara Regnér Tanja Stocks Bas Bueno-de-Mesquita Roel C.H. Vermeulen Dagfinn Aune Tammy Y.N. Tong Nathalie Kliemann Neil Murphy Marc Chadeau-Hyam Marc J. Gunter Amanda J. Cross 《International journal of cancer. Journal international du cancer》2020,146(4):929-942
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers. 相似文献
9.
10.