Measurement of myocardial extracellular volume using cardiac dual-energy computed tomography in patients with ischaemic cardiomyopathy: a comparison of different methods

The International Journal of Cardiovascular Imaging - To clarify the consistency and efficiency of four methods for myocardial extracellular volume (ECV) measurement (manual method using...     

国产吗氯贝胺的抗抑郁作用

研究国产吗氯贝胺对抑郁动物模型和单胺氧化酶－Ａ（ＭＡＯ－Ａ）活性的影响。吗氯贝胺５、１０、２０ｍｇ·ｋｇ－１（ｉｇ）可显著对抗利血平（２．８ｍｇ·ｋｇ－１，ｓｃ）引起的大鼠眼睑下垂，其抑制率分别为６０％，８０％与９０％。在小鼠获得性“绝望”实验中，吗氯贝胺５，１５，２５ｍｇ·ｋｇ－１（ｉｇ）可明显缩短小鼠６ｍｉｎ内不动时间。本研究尚证实，吗氯贝胺６，１２，２４ｍｇ·ｋｇ－１（ｉｇ）可抑制小鼠脑组织中ＭＡＯ－Ａ活性，并与剂量呈明显依赖关系。一次给予小鼠２４ｍｇ·ｋｇ－１（ｉｇ），２ｈ后吗氯贝胺对ＭＡＯ－Ａ活性的抑制作用达高峰（７４．７％），４ｈ后ＭＡＯ－Ａ活性开始有所恢复，于用药后１６ｈ活性已基本趋于正常。     

Investigation of Adhesive’s Material in Hermetic MEMS Package for Interfacial Crack between the Silver Epoxy and the Metal Lid during the Precondition Test

A hermetic Micro-Electro-Mechanical Systems (MEMS) package with a metal lid is investigated to prevent lid-off failure and improve its reliability during the precondition test. While the MEMS package benefits from miniaturization and low cost, a hermetic version is highly sensitive to internal pressure caused by moisture penetration and the reflow process, thus affecting its reliability. In this research, the finite element method is applied to analyze the contact stress between the metal lid and the silver epoxy by applying the cohesive zone model (CZM). Moreover, the red dye penetration test is applied, revealing a microcrack at the metal lid/silver epoxy interface. Further analyses indicate that the crack is caused by internal pressure. According to the experimental testing and simulation results, the silver epoxy material, the curing process, the metal lid geometry, and the bonding layer contact area can enhance the bonding strength between the metal lid and the substrate.     

高血压性左室肥厚患者的校正QT间期离散度变化及临床意义

目的：研究高血压性左室肥厚患者的ＱＴｃｄｅ变化及临床意义。方法;采用１２导联心电图同步记录,超声检查一动态心电图监测５６例高血压患者的ＱＴｃｄ,心脏形态和心律失常。结果：高血压病组和对照组间ＱＴｃｄ差异非常显著,高血压伴ＬＶＨ组和室性心律失常组的ＱＴｃｄ均显著长于无伴ＬＶＨ组和或无ＶＡｓ组;ＬＶＨ组ＶＡｓ和复杂型心律失常发生率均显著高于无ＬＶＨ组。