Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood through adulthood, men have a higher incidence of stroke compared with women. Abundant research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in stroke. Au...     

Glial regenerative response in the imaginal discs of Drosophila melanogaster

<正>Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional plasticity.In response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior     

Gangliosides in nervous system development,regeneration, and pathologies

Gangliosides, sialic acid-containing sphingolipids, are major constituents of neuronal membranes. According to the number of sialic acids and the structure of the oligosaccharide chain, gangliosides can be classified as simple or complex and grouped in different ganglio-series. Hundreds of gangliosides have been identified in vertebrate cells, with different expression patterns during development and related to several physiological processes, especially in the nervous system. While GD3 and its ...     

瘢痕松解术联合纵切横缝术治疗医源性肛门狭窄的临床疗效观察

目的观察瘢痕松解术联合纵切横缝术治疗医源性肛门狭窄的临床疗效。方法将2017年5月至2018年5月在江西中医药大学附属医院收治住院的40例医源性肛门狭窄患者,按随机分组法分为两组,各20例。治疗组采用瘢痕松解术联合纵切横缝术治疗,对照组采用瘢痕松解术治疗。观察两组患者治疗前后肛管直径的变化、术后临床疗效、手术切口完全愈合所需时间及术后疼痛情况、术后半年随访情况。运用SPSS17.0统计软件进行分析。结果治疗组治疗有效率为100%,对照组为85%,差异具有统计学意义(P0.05)。与对照组相比较,治疗组切口完全愈合所需时间更短,治疗前后肛管直径变化更大、术后半年复发率更低。在术后疼痛方面,术后第14天,治疗组VAS疼痛积分明显小于对照组,有显著性差异(P0.05)。结论瘢痕松解术联合纵切横缝术治疗医源性肛门狭窄,具有更好的临床效果,可明显改善患者术后的疼痛感及明显缩短切口恢复时间,值得在临床上推广使用。     

心室肌脂肪:一个意想不到的远期生存生物标志物?

正目的非增强CT常常观察到心肌脂肪,但对其认识不足,本文旨在探究心肌内脂肪与全因死亡率的关系,无论是否有心肌梗死病史。方法本回顾性队列研究收集了不     

基于实体瘤疗效评价标准1.1版(RECIST1.1)中的体积阈值:肝转移瘤治疗效果评估

正摘要目的根据临床经验确定肝转移瘤的体积阈值,以评估肝转移瘤的治疗效果及其进展,并使其与线性RECIST阈值保持一致。方法选取最初参加多中心临床Ⅲ期试验的     

可疑儿童急性阑尾炎的首选MRI诊断评估

正摘要随着腹部MRI技术的进步,无需静脉注射或口服对比剂即可实现快速、自由呼吸成像。对于疑似阑尾炎,MRI作为首选成像方法尚未有相关研究。目的探讨MRI作为可     

急性和慢性缺血性病变在多脑血管病变中的临床意义

正摘要目的探讨3.0 T MR多区域病变模式(MTLP)中急、慢性缺血性的关系及其病因学,特别是与房颤相关的脑卒中。方法分析1 000多项研究的数据,这是一项连续纳入     

软组织肉瘤:与组织学分级和病人预后相关的MRI特征评估

正摘要软组织肉瘤的治疗依赖于组织学分级,这是最重要的预后因素和活检后常规评估。然而,由于肿瘤的异质性,组织学分级可能会被低估。目的确定与高级别软组织肉瘤