PPH治疗中重度痔临床分析

吻合器痔上粘膜环切术（PPH）是近几年来开展的治疗痔的新术式，我院2003年2月起应用PPH技术治疗痔150例治疗效果较好，分析如下：[第一段]     

EXPERIMENTAL STUDY ON THE CYTOCIDAL EFFECT OF AT-1840 AND PARVOVIRUS H-1 AGAINST STOMACH CANCER CELLS

We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future.     

细小病毒和肿瘤

人们对病毒能致癌已确信无疑。本文介绍病毒与肿瘤的另一方面,即细小病毒有抗肿瘤活性。 一、细小病毒的一般特征 细小病毒是已知的最小的动物病毒之一,至今已发现的不下于数十种。根据病毒复制是否需要其他病毒的帮助,分为自主性细小病毒与非自主性细小病毒;前者能在宿主细胞内独立完成复制,后者主要指腺相关病毒(AAV),其复制需“帮助病毒”(腺病     

哺乳动物细小病毒的抗肿瘤作用

病毒和肿瘤的相关性一直引起人们的密切关注。肿瘤病毒,包括 DNA 病毒和反转录 RNA病毒,与动物致癌的直接因果关系已得到证实。人类肿瘤发生的病毒病因仍在探索之中。然而,某些哺乳动物病毒却具有抑制肿瘤的功能。这方面报道不多。60年代以来,在哺乳动物中陆续发现和分离了许多具有相似理化性质与生物学特性的病毒,国际病毒命名学会(ICNV)称之为细小病毒(Parvoviruses)。它们是一类直径为     

PRELIMINARY COMPARISON OF SENSITIVITY TOWARD PARVO VIRUS H-1 OF HUMAN HEP ATOM A CELLS AND PARAHEPATOMA TISSUE

Preliminary observations on the result of infection by parvovirus of primary cultured cells of human hepatoma and parahepatoma tissue were reported. Human hepatoma and parahepatoma tissue were obtained by the culture method of tissue fragment plating. It was observed that their respective sensitivity to parvovirus H-1 was different. H-1 had inhibitory effect on epithelial cells of hepatoma tissue but without any significant effect on fibroblasts simultaneously, H-l had no effect on epithelial cells and fibroblasts of parahepatoma tissue. Further investigation of the relationship between parvovirus and hepatoma would be helpful not only in elucidating the mechanism of carcinogenesis and its suppression but also in the search of new approach for the treatment of hepatoma.     

分子放射生物学中几个探讨中的课题

分子生物学对放射生物学的很多方面有着决定性的影响。     

细小病毒/人细胞系统检测理化因素致突性的应用前景

历史回顾 到目前为止,已有许多系统被用来进行环境致突物的检测,但各系统均有其局限性,本文介绍的是一种80年代发展起来的低剂量环境致突物检测手段——细小病毒/人细胞系统。 环境理化因素的致畸、致突、致癌(以下简称“三致”)是理化因子作用于生物细胞的主要遗传物质——DNA,造成DNA的各种损伤,引起突变、畸变、癌变的表型。怎样     

Research and development of cancer-targeting vectors: An exploration on oncotropism and oncosuppression of autonomous parvoviruses

Usually, retroviruses, adenoviruses, herpes virusesand adeno-associated viruses are used as vectors in genetherapy research. These vectors transport the therapeuticgene into their target cells. Each vector has shown its ownspecific features.Retroviruses are integfated randomly to the host cellchromosomes, ensuring that the exogenous genes beexpressed steadily and in long-term. However, there arerisks of inducing mutagenesis and carcinogenesis. Whenthe HSV/tk gene is transduced into mouse fib…     

哺乳类细胞中DNA损伤诱导的条件反应、诱导性易错修复功能以及体细胞突变和癌变

对DNA损伤修复特别是诱导性易错修复(inducible error-prone repair)机理的研究方兴未艾;主要原因是DNA损伤及其修复同致突变和致癌有直接关系,易错修复造成细胞突变;而体细胞突变又可导致癌变。本文简述哺乳类细胞中由DNA损伤诱导的条件反应,类似细菌SOS修复的诱导性易错功能以及与致突变、致癌的关系。