排序方式: 共有6条查询结果,搜索用时 218 毫秒
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Pérez-Sayáns Mario González-Juanatey José R. Lorenzo-Pouso Alejandro I. Chamorro-Petronacci Cintia M. Blanco-Carrión Andrés Marichalar-Mendía Xabier Somoza-Martín José M. Suárez-Quintanilla Juan A. 《Odontology / the Society of the Nippon Dental University》2021,109(3):574-584
Odontology - The objective of this paper is to clarify the rate of abdominal obesity (AO), waist-to-height ratio (WHtR), metabolic syndrome (MetS) and determine the relationship with the... 相似文献
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Available patient-centered Internet information on peri-implantitis. Can our patients understand it?
Leira Yago Castelo-Baz Pablo Pérez-Sayáns Mario Blanco Juan Lorenzo-Pouso Alejandro Ismael 《Clinical oral investigations》2019,23(4):1569-1574
Clinical Oral Investigations - The aim of this study was to evaluate the quality, readability, and popularity of patient-oriented online information about peri-implantitis. The term... 相似文献
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Alejandro I. Lorenzo-Pouso Mario Pérez-Sayáns Cintia Chamorro-Petronacci Pilar Gándara-Vila Pía López-Jornet Javier Carballo Abel García-García 《Journal of oral pathology & medicine》2020,49(3):190-200
Consensus has yet to be reached about the prevention and treatment of medication-related osteonecrosis of the jaw (MRONJ), which is a treatment sequela of several antiresorptive therapies and other pharmaceutical interventions. Several epidemiologic studies have identified periodontal disease (PD) as a risk factor for this outcome. Thus, the objective of this systematic review and meta-analysis was to investigate this association and its magnitude. A systematic search in MEDLINE via PubMed, Scopus and ISI Web of Science, and a meta-analysis were undertaken. Observational studies that gathered information regarding prefixed definitions for both outcomes were selected, and the relevant information was then extracted, and their risk of bias was evaluated using the Newcastle-Ottawa Scale. The protocol of the study was registered on PROSPERO (CRD42019125646). The initial search yielded 757 eligible records, of which 12 were deemed adequate for inclusion (5 cohort studies and 7 case-control studies). On a random-effects meta-analysis, the risk of PD in MRONJ-affected sites compared with at-risk non-affected patients was significantly greater, with a risk ratio of 2.75 (95% CI: 1.67-4.52). Nonetheless, from a pooled analysis of three standardized periodontal measures (ie plaque index, clinical attachment loss and probing depth) no significant results were obtained. MRONJ appears to be associated with an increase in prevalence of PD. The direction of this association, and the factors influencing it must be investigated using further prospective data, and likewise, the possibility for using periodontal therapy as a prevention strategy must be looked into. Periodontal screening needs to be made an indispensable requisite for clinicians in order to establish a correct multidisciplinary approach in MRONJ. 相似文献
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Alejandro I. Lorenzo-Pouso Fernando Rodríguez-González Andrés Blanco-Carrión Abel García-García Cintia Chamorro-Petronacci Pía López-Jornet 《Acta odontologica Scandinavica》2020,78(7):501-508
AbstractObjectives: Due to their anti-inflammatory and immunosuppressive effects, topical corticosteroids (TCs) are commonly used for the treatment of patients with oral lichen planus (OLP) with an erosive or ulcerative component. It has been suggested that many of these patients may suffer from fear or anxiety as a result of prolonged treatment with TCs. The objective of this study was twofold: (1) to optimise a patient reported outcome measure (PROM) in order to explore this feature, and (2) to evaluate this PROM in the treatment of OLP patients.Methods: A group of qualitative researchers adapted the TOPICOP questionnaire in order for it to be used as a PROM for OLP via structural equation modelling (SEM) and internal consistency (IC) analysis. Consequently, 34 patients with symptomatic OLP who were undergoing treatment with TCs completed a questionnaire and underwent a clinical assessment.Results: SEM presented an adequate fit (RMSA = 0.07, CFI = 0.94 and WRMR = 1.18), as well as a high IC (α?=?0.81). A total of 16 patients (47.1%) reported TCs phobia. The receiver operating characteristic analysis (ROC) revealed that a TOPICOP value ≥50% predicted the presence of TCs phobia with a sensitivity of 93% and a specificity of 100%.Conclusions: The optimised TOPICOP scale proved valuable as a PROM in OLP. TCs phobia can be a real consideration in OLP, nonetheless, it does not appear to be an impediment to treatment adherence. 相似文献
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Pérez-Sayáns Mario Lorenzo-Pouso Alejandro I. Galindo-Moreno Pablo Muñoz-Guzón Fernando González-Cantalapiedra Antonio López-Peña Mónica Somoza-Martín Manuel Gallas-Torreira Mercedes García-García Abel 《Odontology / the Society of the Nippon Dental University》2019,107(2):209-218
Odontology - This study compared the in vivo behavior of two biomaterials, xenograft (Bio-Oss®) and alloplastic tricalcium phosphate (Sil-Oss®), vs a control (no biomaterial) in beagle... 相似文献
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Alejandro I. Lorenzo-Pouso Susana B. Bravo Javier Carballo María del Pilar Chantada-Vázquez José Bagán Leticia Bagán Cintia M. Chamorro-Petronacci Mercedes Conde-Amboage Rafael López-López Abel García-García Mario Pérez-Sayáns 《Oral diseases》2023,29(5):2117-2129
Objective
Medication-related osteonecrosis of the jaw (MRONJ) is a paradoxical effect associated with bone-modifying agents (BMAs) and other drugs. Currently, no valuable diagnostic or prognosis biomarkers exist. The goal of this research was to study MRONJ-related salivary proteome.Materials and Methods
This case–control aimed to study salivary proteome in MRONJ versus control groups (i) formed from BMAs consumers and (ii) healthy individuals to unravel biomarkers. Thirty-eight samples of unstimulated whole saliva (18 MRONJ patients, 10 BMA consumers, and 10 healthy controls) were collected. Proteomic analysis by SWATH-MS coupled with bioinformatics analysis was executed.Results
A total of 586 proteins were identified, 175 proteins showed significant differences among MRONJ versus controls. SWATH-MS revealed differentially expressed proteins among three groups, which have never been isolated. These proteins had distinct roles including cell envelope organization, positive regulation of vesicle fusion, positive regulation of receptor binding, or regulation of low-density lipoprotein particle clearance. Integrative analysis prioritized 3 proteins (MMP9, AACT, and HBD). Under receiver-operating characteristic analysis, this panel discriminated MRONJ with a sensitivity of 90% and a specificity of 78.9%.Conclusion
These findings may inform a novel biomarker panel for MRONJ prediction or diagnosis. Nonetheless, further research is needed to validate this panel. 相似文献
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