An Automated System for Leukofiltration of Blood Components

Biomedical Engineering - An automated system for filtering blood transfusion media through special filters, monitoring and logging the filtration parameters, and processing filtration protocols is...     

HIV and Substance Use Stigma,Intersectional Stigma and Healthcare Among HIV-Positive PWID in Russia

AIDS and Behavior - Little is known about the intersection of HIV stigma and substance use stigma. Using data from 188 HIV-positive people who inject drugs (PWID) in Russia, we examined the...     

Tilorone, a synthetic immunostimulator possessing antitumor activity]

The authors report the results of studies on antitumor, immunostimulating and interieron-inducing properties of diethylamine fluorene derivative--tiloron, synthesized at Odessa laboratories of IGIC of the Ukrainian SSR Academy of Sciences by the originally elaborated method. It was found that tiloron does not suppress leucopoiesis, stimulates a number of protective reactions of the organism, including the factors of humoral and cell immunity, especially manifested under immunosuppression. Tiloron is shown to possess the definite antitumor activity being retained in peroral administration of the drug. Tiloron used together with cytostatic agents results in enhanced suppression of experimental tumors growth. Antitumor and immunostimulating action of tiloron on the experimental patterns under study is believed by the authors to be somewhat related with its interieron-inducing ability.     

Bioluminescence assays: effects of quinones and phenols

The influence of a series of quinones and phenols on bacteria bioluminescence systems was investigated. Three bioluminescence systems used in ecological monitoring were compared: (1) water-soluble; (2) immobilized in starch gel coupled enzyme systems: NADH:FMN-oxidoreductase-luciferase; (3) luminescent bacteria. Bioluminescence inhibition constants of quinones and phenols and bioluminescence induction periods were compared. These kinetic parameters are proportional to quinone concentrations and depend on the quinone redox potential. Different effects of the substances are related to structure and properties of the bioluminescence systems. The set of bioluminescence assays for quinones and phenols monitoring should include two bioluminescence systems: 1 (or 2) and 3.     

Effect of Tilorone on the Dynamics of Viral Load and the Levels of Interferons and Interleukin-1β in the Lung Tissue and Blood Serum of Mice with Experimental Influenza

Bulletin of Experimental Biology and Medicine - We studied the effect of tilorone on the dynamics of IFNα, IFNγ, and IL-1β levels in the lung tissue and blood serum in relation to...     

Monoclonal antibodies IPO-3 and IPO-10 against human B cell differentiation antigens

Monoclonal antibodies (mAbs) IPO-3 and IPO-10 were generated following immunization of a BALB/c mice with human cell lines RPMI-1788 and Daudi respectively. The reactivity of these mAbs was studied by indirect immunofluorescence technique with 10 human cell lines, blood cells of healthy persons and patients with the malignant lymphoproliferative diseases. Studies of normal and neoplastic B cells suggest that mAbs IPO-3 and IPO-10 which recognize antigens are B lineage restricted. The presence of an antigen defined by the mAb IPO-10 appears to include most but not all the stages of B cell differentiation, whereas IPO-3 detected antigen is not represented on resting B cells and has a very limited expression on activated B lymphocytes. The results obtained with mAbs IPO-3 and IPO-10 are discussed in relation to other known B cell surface markers.