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1.
Ricardo Melendez-Munoz Rachel Marchalik Theresa Jerussi Dimana Dimitrova Veronique Nussenblatt Andrea Beri Khalid Rai Jennifer S. Wilder A. John Barrett Minoo Battiwalla Richard W. Childs Courtney D. Fitzhugh Daniel H. Fowler Terry J. Fry Ronald E. Gress Matthew M. Hsieh Sawa Ito Elizabeth M. Kang Jennifer A. Kanakry 《Biology of blood and marrow transplantation》2019,25(3):577-586
Human cytomegalovirus (CMV) infection and disease remains a significant cause of morbidity and mortality for hematopoietic cell transplantation (HCT) recipients. Disruption of or weak reconstitution of virus-specific cellular immune function, such as with certain HCT approaches, poses significant risk for CMV-related complications. The incidence of and risk factors for CMV infection and the nature of CMV disease were evaluated retrospectively among 356 consecutive HCT recipients transplanted at the National Institutes of Health using all graft sources, including bone marrow, peripheral blood stem cell (PBSC), and umbilical cord blood (UCB), and a range of in vivo and ex vivo approaches for graft-versus-host disease (GVHD) prophylaxis. The cumulative incidence of CMV infection was higher for CMV-seropositive recipients at 33%, regardless of donor CMV serostatus. Patients transplanted with CMV-seropositive donors had a significantly shorter duration of antiviral therapy. Among graft sources UCB was associated with the highest cumulative incidence of CMV infection at 65% and significantly longer treatment duration at a median of 36days, whereas PBSC HCT was associated with the lowest incidence at 26% and the shortest CMV treatment duration at a median of 21days. There were significant differences in the cumulative incidence of CMV infection by T cell manipulation strategy when systemic steroids were included as a risk-modifying event. Over one-third of CMV infections occurred in the setting of systemic steroid administration. CMV disease occurred in 5% of HCT recipients, with 70% of cases in the setting of treatment for GVHD. Although factors related to serostatus, graft source, and GVHD prophylaxis were associated with varied CMV infection incidence, unplanned post-HCT corticosteroid therapy contributed greatly to the incidence of both CMV infection and disease across HCT approaches, highlighting this post-HCT intervention as a key time to potentially tailor the approach to monitoring, preemptive therapy, and even prophylaxis. 相似文献
2.
Farhad Tabatabaian Alireza Jafari Mahshid Namdari Minoo Mahshid 《The Journal of prosthetic dentistry》2019,121(2):327-332
Statement of problem
The effects of coping and veneer thickness on the color of zirconia-based restorations are unknown.Purpose
The purpose of this in vitro study was to evaluate the influence of coping and veneer thickness on the color of zirconia-based restorations on different implant abutment backgrounds and to define minimum coping and veneer thicknesses for the backgrounds investigated to achieve a target color.Material and methods
Thirty zirconia disk specimens with thicknesses of 0.4, 0.6, and 0.8 mm and 30 veneering ceramic disk specimens with thicknesses of 0.8, 1.0, and 1.2 mm were fabricated. Three backgrounds were prepared: titanium alloy, zirconia ceramic, and base metal alloy. The zirconia specimens were placed on the backgrounds, and the veneering ceramic specimens were located on the zirconia specimens. Spectrophotometric measurements were made to determine CIELab values. Color difference (ΔE) values were calculated to measure color differences between the specimens and the A2 VITA classical shade tab. ΔE values were compared with a perceptibility threshold (ΔE=2.6). Repeated measures ANOVA, Bonferroni test, and 1-sample t test were used to analyze data (α=.05).Results
Mean ΔE values ranged from 2.0 to 9.8. Coping thickness, veneer thickness, and their combination significantly affected ΔE (P<.001).Conclusions
To achieve the target color with zirconia-based restorations, regardless of the backgrounds tested, the minimum thickness of zirconia coping should be 0.6 mm, and the minimum thickness of veneering ceramic should be 1.2 mm. 相似文献3.
Talon cusp is an uncommon anomaly, whose etiology may be disturbances in the morphodifferentiation stage. Dens in dente is also a rare anomaly that is challenging in clinic as it may cause pulp necrosis or periapical lesions due to the communication with the oral cavity. This article reports multiple talon cusps on permanent maxillary and mandibular incisors and molars in 3 siblings. A 9-year-old boy presented with structures like nodules, shaped as cylindrical cones with a sharp point or a raindrop with deep developmental fissures on the palatal aspect of the maxillary central incisors, lingual aspect of the mandibular central incisors and labial aspect of both mandibular first molars. The buccal surface of the maxillary right central incisor was also affected. Some of them exhibited dens in dente. His 15-year-old sister had prominent talon cusps on the palatal surface of maxillary central incisors and buccal surface of the mandibular first molars and mandibular left second molar. His 7-year-old brother had only one trace talon on the maxillary left central incisor. No syndrome was identified in the patients. In conclusion, genetic inheritance may be a causative factor in talon cusp. 相似文献
4.
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6.
Caroline R. Cantilena Sawa Ito Xin Tian Prachi Jain Fariba Chinian Prathima Anandi Keyvan Keyvanfar Debbie Draper Eleftheria Koklanaris Sara Hauffe Jeanine Superata David Stroncek Pawel Muranski A. John Barrett Minoo Battiwalla 《Biology of blood and marrow transplantation》2018,24(3):460-466
Various approaches have been developed for ex vivo T cell depletion in allogeneic stem cell transplantation to prevent graft-versus-host disease (GVHD). Direct comparisons of T cell depletion strategies have not been well studied, however. We evaluated cellular and plasma biomarkers in 2 different graft manipulation strategies, CD3+CD19+ cell depletion (CD3/19D) versus CD34+ selection (CD34S), and their associations with clinical outcomes. Identical conditions, including the myeloablative preparative regimen, HLA-identical sibling donor, GVHD prophylaxis, and graft source, were used in the 2 cohorts. Major clinical outcomes were similar in the 2 groups in terms of overall survival, nonrelapse mortality, and cumulative incidence of relapse; however, the cumulative incidence of acute GVHD trended to be higher in the CD3/19D cohort compared with the CD34S cohort. A distinct biomarker profile was noted in the CD3/19D cohort: higher levels of ST2, impaired Helios? FoxP3+Treg reconstitution, and rapid reconstitution of naïve, Th2, and Th17 CD4 cells in the early post-transplantation period. In vitro graft replication studies confirmed that CD3/19D disproportionately depleted Tregs and other CD4 subset repertoires in the graft. This study confirms the utility of biomarker monitoring, which can be directly correlated with biological consequences and possible future therapeutic indications. 相似文献
7.
8.
Javed Hussain Farooqui Archana Koul Ranjan Dutta Noshir Minoo Shroff 《Saudi Journal of Ophthalmology》2015,29(4):264-269
Purpose
Visual performance following toric intraocular lens implantation for cataract with moderate and severe astigmatism.Setting
Cataract services, Shroff Eye Centre, New Delhi, India.Design
Case series.Method
This prospective study included 64 eyes of 40 patients with more than 1.50 dioptre (D) of pre-existing corneal astigmatism undergoing phacoemulsification with implantation of the AcrySof® toric IntraOcular Lens (IOL). The unaided visual acuity (UCVA), best corrected visual acuity (BCVA), residual refractive sphere and refractive cylinders were evaluated. Toric IOL axis and alignment error was measured by slit lamp method and Adobe Photoshop (version 7) method. Patient satisfaction was evaluated using a satisfaction questionnaire at 3 months.Results
The mean residual refractive astigmatism was 0.57 D at the final follow-up of 3 months. Mean alignment error was 3.44 degrees (SD = 2.60) by slit lamp method and 3.88 degrees (SD = 2.86) by Photoshop method. Forty-six (71.9%) eyes showed misalignment of 5 degrees or less, and 60 (93.8%) eyes showed misalignment of 10 degrees or less. The mean log MAR UCVA at 1st post-op day was 0.172 (SD = 0.02), on 7th post-op day was 0.138 (SD = 0.11), and on 30th post-op day was 0.081 (SD = 0.11). The mean log MAR BCVA at three months was −0.04 (SD = 0.76).Conclusion
We believe that implantation of AcrySof® toric IOL is an effective, safe and predictable method to correct high amounts of corneal astigmatism during cataract surgery. 相似文献9.