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排序方式: 共有836条查询结果,搜索用时 31 毫秒
1.
Kosuke Yoshihara Takayuki Enomoto Daisuke Aoki Yoh Watanabe Junzo Kigawa Nobuhiro Takeshima Hyoe Inomata Kana Hattori Masahisa Jinushi Hitoshi Tsuda Toru Sugiyama 《Cancer science》2020,111(9):3350-3358
Whether germline (g) breast cancer susceptibility gene (BRCA) mutations are located within or outside the ovarian cancer cluster region (OCCR) (1380‐4062 bp for gBRCA1, and between 3249‐5681 bp and 6645‐7471 bp for gBRCA2) may influence risk variations for ovarian cancers. This ad hoc analysis of the CHARLOTTE epidemiological study in Japan assessed the distribution of gBRCA1/2 mutations in patients with newly diagnosed ovarian cancer, and investigated an association between gBRCA1/2 mutation locations and ovarian cancer risk. Differences in patient background and clinical characteristics in subgroups stratified by gBRCA1/2 mutation locations were also evaluated. We analyzed the data of 93 patients (14.7%) from the CHARLOTTE study who were positive for gBRCA1/2 mutations. After excluding 16 cases with L63X founder mutation, 28 (65.1%) of gBRCA1 mutations were within the OCCR. Of 30 gBRCA2 mutations, 15 (50.0%) were within the OCCR. Of 27 patients (one patient excluded for unknown family history) with gBRCA1 mutations located in the OCCR, 11 (40.7%) had a family history of ovarian cancer; the proportion of patients with a family history of ovarian cancer and gBRCA1 mutations outside the OCCR was lower (13.3%). Sixty percent of patients with gBRCA1 mutations outside the OCCR had a family history of breast cancer; the proportion of patients with a family history of breast cancer and gBRCA1 mutations within the OCCR was relatively lower (33.3%). Understanding the mutation locations may contribute to more accurate risk assessments of susceptible individuals and early detection of ovarian cancer among gBRCA mutation carriers. 相似文献
2.
Takashi Ando Yuichi Riku Akio Akagi Hiroaki Miyahara Mitsuaki Hirano Toshimasa Ikeda Hiroyuki Yabata Ryuichi Koizumi Chisato Oba Saori Morozumi Keizo Yasui Atsuko Goto Taiji Katayama Satoko Sakakibara Ikuko Aiba Motoko Sakai Masaaki Konagaya Keiko Mori Yasuhiro Ito Hiroyuki Yuasa Masayo Nomura Kristine Joyce L. Porto Jun Mitsui Shoji Tsuji Maya Mimuro Yoshio Hashizume Masahisa Katsuno Yasushi Iwasaki Mari Yoshida 《Brain pathology (Zurich, Switzerland)》2022,32(1):e13002
The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, and alpha-synuclein-immunoreactive inclusions. MSA patients who displayed abundant neuronal cytoplasmic inclusions (NCIs) in the regions other than the striatonigral or olivopontocerebellar system have occasionally been diagnosed with variants of MSA. In this study, we report clinical and pathologic findings of MSA patients characterized by prominent pathologic involvement of the hippocampus. We assessed 146 consecutively autopsied MSA patients. Semi-quantitative analysis of anti-alpha-synuclein immunohistochemistry revealed that 12 of 146 patients (8.2%) had severe NCIs in two or more of the following areas: the hippocampal granule cells, cornu ammonis areas, parahippocampal gyrus, and amygdala. In contrast, the remaining 134 patients did not show severe NCIs in any of these regions. Patients with severe hippocampal involvement showed a higher representation of women (nine women/three men; Fisher's exact test, p = 0.0324), longer disease duration (13.1 ± 5.9 years; Mann–Whitney U-test, p = 0.000157), higher prevalence of cognitive impairment (four patients; Fisher's exact test, p = 0.0222), and lower brain weight (1070.3 ± 168.6 g; Mann–Whitney U-test, p = 0.00911) than other patients. The hippocampal granule cells and cornu ammonis area 1/subiculum almost always showed severe NCIs. The NCIs appeared to be ring-shaped or neurofibrillary tangle-like, fibrous configurations. Three of 12 patients also had dense, round-shaped NCIs that were morphologically similar to pick bodies. The patients with Pick body-like inclusions showed more severe atrophy of the medial temporal lobes and broader spreading of NCIs than those without. Immunohistochemistry for hyperphosphorylated tau and phosphorylated TDP-43 revealed minimal aggregations in the hippocampus of the hippocampal MSA patients. Our observations suggest a pathological variant of MSA that is characterized by severe involvement of hippocampal neurons. This phenotype may reinforce the importance of neuronal alpha-synucleinopathy in the pathogenesis of MSA. 相似文献
3.
4.
Teruhiko Takayama Yuji Mizukami Akihiro Takemura Katsuhiro Ichikawa Masahisa Onoguchi Takao Taniya 《Journal of Medical Ultrasonics》2008,35(4):207-210
We report a case of small-cell carcinoma of the breast. The patient was a 54-year-old Japanese woman with a left breast mass.
Mammography revealed a 1.2-cm microlobulated mass with partially ill-defined borders. Ultrasonography disclosed a hypoechoic
mass measuring 1.8 × 1.2 × 1.2 cm with heterogeneous internal echoes and partially ill-defined borders. The shape of the mass
was round and taller than it was wide in the orthogonal section to the longest axis of the mass. These imaging findings suggested
a malignant tumor. Fine-needle aspiration cytology of the tumor also suggested a ductal carcinoma. Breast-conserving surgery
was performed with axillary sentinel lymph node biopsy. A diagnosis of small-cell carcinoma of the breast was made based on
the histologic and immunohistochemical findings. This rare breast tumor has been reported to be aggressive and associated
with a poor prognosis; however, our patient is currently well and has had no clinical recurrence of the disease after 5 years
of follow-up without radiotherapy or chemotherapy. Therefore, the prognosis may be better if the tumor is detected early and
there is an absence of lymph node metastasis. 相似文献
5.
Satoshi Daitoku Toshinori Yuasa Hiroshi Tsunenari Shigeho Maenohara Kazuharu Mine Yuichi Tamatsu Kazuyuki Shimada Chihaya Koriyama Mitsuru Ohishi Masahisa Horiuchi 《Environmental health and preventive medicine》2015,20(3):216-223
Objectives
Although carotid artery structural variations have been detected by ultrasound, their clinical significance is not fully understood. The objective of this study was to determine whether the angle between the common carotid artery (CCA) and the internal carotid artery (ICA), designated angle α, an ultrasound-detectable carotid artery structural variation, is related to carotid artery intima-media thickness (IMT), a surrogate marker for carotid atherosclerosis.Methods
As a cross-sectional study, we measured angle α in routine carotid artery ultrasounds from 176 subjects (130 men) with atherosclerotic disease/risk factors that attended Kouseiren Hospital in Kagoshima City, Japan between August 2007 and April 2009. We evaluated the correlation between the angle α and CCA- or ICA-IMT.Results
Angle α was weakly correlated with age but significantly correlated with ICA-IMT. The correlation was stronger in subjects with an ICA-IMT ≥ 0.5 mm than in those with an ICA-IMT < 0.5 mm (Right side r = 0.475 vs. 0.246, Left side r = 0.498 vs. 0.301, respectively). Upon multivariate logistic regression analysis, angle α and serum low-density lipoprotein cholesterol were independent explanatory variables for ICA-IMT.Conclusion
Angle α is related to ICA-IMT in subjects with atherosclerotic disease or risk factors in this study.Electronic supplementary material
The online version of this article (doi:10.1007/s12199-015-0453-7) contains supplementary material, which is available to authorized users. 相似文献6.
7.
8.
Masahisa Jinushi 《Cancer metastasis reviews》2014,33(2-3):737-745
Emerging evidence has unveiled a critical role for immunological parameters in predicting tumor prognosis and clinical responses to anticancer therapeutics. On the other hand, responsiveness to anticancer drugs greatly modifies the repertoires, phenotypes, and immunogenicity of tumor-infiltrating immune cells, serving as a critical factor to regulate tumorigenic activities and the emergence of therapy-resistant phenotypes. Tumor-associated immune functions are influenced by distinct or overlapping sets of therapeutic modalities, such as cytotoxic chemotherapy, radiotherapy, or molecular-targeted therapy, and various anticancer modalities have unique properties to influence the mode of cross-talk between tumor cells and immune cells in tumor microenvironments. Thus, it is critical to understand precise molecular machineries whereby each anticancer strategy has a distinct or overlapping role in regulating the dynamism of reciprocal communication between tumor and immune cells in tumor microenvironments. Such an understanding will open new therapeutic opportunities by harnessing the immune system to overcome resistance to conventional anticancer drugs. 相似文献
9.
Doo‐Yi Oh Yoshihiro Matsumoto Shin‐ichiro Kitajiri Nayoung K.D. Kim Min Young Kim Ah Reum Kim Mingyu Lee Chung Lee Alan E. Tomkinson Tatsuya Katsuno So Young Kim Hyun‐Woo Shin Jin Hee Han Seungmin Lee Woong‐Yang Park Byung Yoon Choi 《Human mutation》2020,41(5):913-920
DNA polymerase δ, whose catalytic subunit is encoded by POLD1, is responsible for synthesizing the lagging strand of DNA. Single heterozygous POLD1 mutations in domains with polymerase and exonuclease activities have been reported to cause syndromic deafness as a part of multisystem metabolic disorder or predisposition to cancer. However, the phenotypes of diverse combinations of POLD1 genotypes have not been elucidated in humans. We found that five members of a multiplex family segregating autosomal recessive nonsyndromic sensorineural hearing loss (NS‐SNHL) have revealed novel compound heterozygous POLD1 variants (p.Gly1100Arg and a presumptive null function variant, p.Ser197Hisfs*54). The recombinant p.Gly1100Arg polymerase δ showed a reduced polymerase activity by 30–40%, but exhibited normal exonuclease activity. The polymerase activity in cell extracts from the affected subject carrying the two POLD1 mutant alleles was about 33% of normal controls. We suggest that significantly decreased polymerase δ activity, but not a complete absence, with normal exonuclease activity could lead to NS‐SNHL. 相似文献
10.
Toru Nakano MD Masahisa Tabata MD Prof. Fumio Nakayma MD Facs 《Digestive diseases and sciences》1988,33(9):1116-1120
To investigate the role of cholangitis in hydrolysis of bilirubin in bile with brown pigment gallstones, bilirubin composition and bacterial growth in hepatic bile with and without cholangitis were studied. The study included 38 brown pigment gallstone cases (28 without cholangitis and 10 with cholangitis). The proportion of unconjugated bilirubin in hepatic bile with cholangitis (16.9±8.5%, mean ± SD) was significantly higher than that without cholangitis (3.7±1.8%, P<0.001. A positive correlation was found between bacterial population with -glucuronidase activity and the proportion of unconjugated bilirubin in bile in cases of brown pigment stones with cholangitis P<0.05) but not in those without cholangitis despite the fact that bacterial species and population are similar regardless of the presence of cholangitis. In cholangitis, pH of bile becomes lower toward the optimal pH of bacterial -glucuronidase. Together the lower concentration of bile acid and the lower pH in bile result in lower solubility of unconjugated bilirubin, promoting its precipitation. Thus occasional bouts of cholangitis may result in periodic deposition of bilirubinate on brown pigment stones with layered structures by inducing cyclic changes of bile composition in situ. 相似文献