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Cytotoxic Effects of Betel Quid and Areca Nut Aqueous Extracts on Mouse Fibroblast,Human Mouth-Ordinary-Epithelium 1 and Human Oral Squamous Cell Carcinoma Cell Lines 下载免费PDF全文
Badr Abdullah Al-TayarAzlina AhmadMohamad Ezany YusoffSiti Fadilah AbdullahNoor Khairiena MohamadSiti Nurnasihah Md HashimShosei KishidaMichiko KishidaNorifumi NakamuraToshiro KibeMasitah Hayati Harun 《Asian Pacific journal of cancer prevention》2020,21(4):1005-1009
Background: Betel quid chewing is more common among the older generation in rural areas of Malaysia. Oral cancer in Asia has been associated with the habit of chewing betel quid and areca nut. Objective: This study aims to investigate the cytotoxic effects of betel quid and areca nut extracts on the fibroblast (L929), mouth-ordinary-epithelium 1 (MOE1) and oral squamous cell carcinoma (HSC-2) cell lines. Methods: L929, MOE1 and HSC-2 cells were treated with 0.1, 0.2 and 0.4 g/ml of betel quid and areca nut extracts for 24, 48 and 72 h. MTT assay was performed to assess the cell viability. Results: Both extracts, regardless of concentration, significantly reduced the cell viability of L929 compared with the control (P<0.05). Cell viability of MOE1 was significantly enhanced by all betel quid concentrations compared with the control (P<0.05). By contrast, 0.4 g/ml of areca nut extract significantly reduced the cell viability of MOE1 at 48 and 72 h of incubation. Cell viability of HSC-2 was significantly lowered by all areca nut extracts, but 0.4 g/ml of betel quid significantly increased the cell viability of HSC-2 (P<0.05). Conclusion: Areca nut extract is cytotoxic to L929 and HSC-2, whereas the lower concentrations of areca nut extract significantly increased the cell viability of MOE1 compared to the higher concentration and control group. Although betel quid extract is cytotoxic to L929, the same effect is not observed in MOE1 and HSC-2 cell lines. Further investigations are needed to clarify the mechanism of action. 相似文献
3.
Saini R Abd Razak NH Ab Rahman S Samsudin AR 《Journal (Canadian Dental Association)》2007,73(2):175-178
Chondrosarcomas are malignant tumours of cartilaginous origin. They range from a well-differentiated growth resembling a benign cartilage tumour to a high-grade malignancy with aggressive local behaviour and the potential to metastasize. Only 5% to 10% of chondrosarcomas are known to occur in the head and neck region. A case of chondrosarcoma of the anterior region of the mandible is presented, along with a review of the relevant literature. 相似文献
4.
Objectives
The purpose of the present study was to determine the inclination and height of the articular eminence with respect to the condylar bone changes, condyle shape, fossa shape and condylar movements in patients with and without temporomandibular joint (TMJ) dysfunction using cone-beam computed tomography (CBCT).Methods
The associations between the eminence inclination and the condylar bone changes, condylar movements, condylar shape and fossa shape were evaluated in patients with TMJ disorders and control patients without TMJ disorders. The measurements of the articular eminence inclination were established on central sagittal slices of the TMJ. The central coronal slices were used to determine the condyle and fossa shapes. The types of movements of the condyles were determined on open-mouth images, and mandibular hypermobility or hypomobility was noted for each joint.Results
There were no significant differences in the eminence inclination and height with respect to the condylar bone changes and condylar movements in the TMJ disorder group. However, there was a significant association between the eminence inclination and the fossa shape in the TMJ disorder group and significant associations between the eminence inclination and both the condyle and fossa shapes in the control group. The articular eminence inclination was steeper in the control group than in the TMJ disorder group.Conclusions
The eminence inclination was steeper in the control patients than in the patients with TMJ disorders, and was not correlated with the condylar bone changes or condylar movements. 相似文献5.
Cakir E Deniz O Ozcan O Tozkoparan E Yaman H Akgul EO Bilgi C Bilgic H Ekiz K Erbil MK 《Clinical biochemistry》2005,38(3):234-238
BACKGROUND: Diagnosis of tuberculous pleuritis is difficult because of its nonspecific clinical presentation and decreased efficiency of traditional diagnostic methods. We investigated the use of procalcitonin (PCT) concentration in tuberculous pleuritis diagnosis. METHODS: A prospective clinical study was performed with two different patient groups. A total of 28 patients were included: 18 with tuberculosis and 10 with nontuberculous pleurisy. Serum and pleural fluid PCT concentrations were evaluated before treatment. RESULTS: Serum and pleural fluid PCT concentrations were statistically different between tuberculous and nontuberculous pleurisy groups (P = 0.012 and P = 0.004, respectively), even though they were not elevated in relation to the cut-off level of 0.5 ng/mL. A positive and significant correlation was detected between serum and pleural fluid PCT levels (r = 0.49, P = 0.008). Diagnostic specificity and sensitivity values for serum and pleural fluid PCT in discriminating tuberculous from nontuberculous pleurisy were 80% and 72.2%, and 90% and 66.7% at the 0.081 and 0.113 ng/mL cut-off values, respectively. CONCLUSION: Relative to the current cut-off level of 0.5 ng/mL, PCT concentration is not a useful parameter for the diagnosis of tuberculous pleurisy. Because there were PCT levels in patients with tuberculous pleurisy that were below the current cut-off level but were significantly different from those of the nontuberculous group, the use of PCT should be further investigated. 相似文献
6.
Solomon B 《Expert opinion on biological therapy》2002,2(8):907-917
The pathology of Alzheimer's disease (AD) shows a significant correlation between beta-amyloid peptide (AbetaP) conformation and the clinical severity of dementia. For many years, efforts have been focused on the development of inhibitors of beta-amyloid (Abeta) formation and its related neurotoxic effects. The author has developed a new concept showing that site-directed antibodies may modulate formation of Abeta. The performance of anti-Abeta antibodies in transgenic mice models of AD showed that they are delivered to the central nervous system (CNS), preventing in vivo formation of Abeta. Moreover, these antibodies dissolve Abeta plaques and protect the mice from learning difficulties and age-related memory deficits. Experimental active immunisation with Abeta (1-42) in humans has been stopped in Phase II of their clinical trials. However, several new preparations, able to provide antibodies against Abeta by either active or passive routes, have been formulated and at least one of these is likely to reach clinical testing. These data support the hypothesis that AbetaP plays a central role in AD and antibodies which modulate Abeta conformation may lead to immunotherapy of the disease. 相似文献
7.
Suleyman Ercan M.D. Gokhan Gokaslan M.D. Vedat Davutoglu M.D. Ibrahim Halil Inanc M.D. Vuslat Bosnak M.D. Hayati Deniz M.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(8):E236-E238
Herein, we present a case of asymptomatic isolated cardiac cystic echinococcosis localized entirely to the inter‐atrial septum in a pregnant woman. The patient underwent successful surgery. Cardiac cystic echinococcosis is rarely seen in pregnancy. A high index of suspicion is necessary for the diagnosis of a cardiac cyst hydatid. The treatment of cardiac cyst hydatid is surgical and should not be delayed during pregnancy. Early surgery might prevent septic embolization and cardiac life‐threatening complications and save the lives of both mother and baby as in the present case. 相似文献
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9.
Macit Kalcik M.D. Cüneyt Toprak M.D. M. Ozan Gursoy M.D. Mahmut Yesin M.D. Lutfi Ocal M.D. Hayati Eren M.D. Mehmet Özkan M.D. 《Echocardiography (Mount Kisco, N.Y.)》2014,31(4):E111-E114
Eustachian valve (EV) is a vestige of the valve of the inferior vena cava which directs the umbilical vein blood through open foramen ovale in fetal life. Following birth it gradually regresses, but it may persist in variable size, shape, and thickness as a functionless and benign structure. However, there are reports suggesting that persistent EV may not be completely innocent. It has been accused of being a predisposing cause of patent foramen ovale and paradoxical embolism and also interfering with transseptal interventional procedures. It may serve as a site of infective vegetations and be mistaken as a tumor or thrombus. In the present case, an octopus‐like thrombus attached to the EV was delineated with the utility of two‐dimensional and real time three‐dimensional transesophageal echocardiography. EV was considered to play an essential role in preventing potential pulmonary embolism. 相似文献
10.
Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies 下载免费PDF全文
Arbel M Yacoby I Solomon B 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(21):7718-7723
Amyloid-beta peptide (AbetaP) that accumulates in the Alzheimer's diseased brain is derived from proteolytic processing of the amyloid precursor protein (APP) by means of beta- and gamma-secretases. The beta-secretase APP cleaving enzyme (BACE), which generates the N terminus of AbetaP, has become a target of intense research aimed at blocking the enzyme activity, thus reducing AbetaP and, subsequently, plaque formation. The search for specific inhibitors of beta-secretase activity as a possible treatment for Alzheimer's disease intensified with the discovery that BACE may be involved in processing other non-APP substrates. The presence of the APP-BACE complex in early endosomes highlights the cell surface as a potential therapeutic target, suggesting that interference in APP-BACE interaction at the cell surface may affect amyloid-beta production. We present here a unique approach to inhibit AbetaP production by means of antibodies against the beta-secretase cleavage site of APP. These antibodies were found to bind human APP overexpressed by CHO cells, and the formed immunocomplex was visualized in the early endosomes. Indeed, blocking of the beta-secretase site by these antibodies interfered with BACE activity and inhibited both intracellular and extracellular AbetaP formation in these cells. 相似文献