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Restoration From Acute Urinary Dysfunction Using Utah Electrode Arrays Implanted Into the Feline Pudendal Nerve 下载免费PDF全文
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Sapna Pathak BS James B. Caress MD Marlena Wosiski-Kuhn BS Carol Milligan PhD Delaney Williams MS Michael S. Cartwright MD MS 《Muscle & nerve》2019,59(2):181-186
Introduction: This study explores the reliability and responsiveness of neuromuscular ultrasound in amyotrophic lateral sclerosis (ALS). Methods: Investigations were conducted with 10 healthy controls, 10 patients with ALS (single point in time), and 10 different patients with ALS (followed over 6 months; 4 completed follow-up). Ultrasound was used to measure the thickness of the geniohyoid, bilateral biceps/brachialis, bilateral tibialis anterior, and bilateral hemidiaphragms (at inspiration and expiration). Interrater and intrarater reliability and change in muscle thickness over 6 months were measured. Results: Interrater correlation coefficients ranged between 0.80 and 0.99 in healthy controls and between 0.78 and 0.97 in patients with ALS. Intrarater correlation coefficients ranged between 0.83 and 0.98 in healthy controls. The mean percentage decline in muscle thickness over 6 months was 20.25%. Discussion: Muscle ultrasound appears to be a reliable technique for measuring important muscles in patients with ALS. Larger studies with age-matched controls should be conducted to assess further the responsiveness of this biomarker in ALS. Muscle Nerve 59 :181–186, 2019 相似文献
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Thomas W. Lycan DO MHS Fang-Chi Hsu PhD Christine S. Ahn MD Alexandra Thomas MD Francis O. Walker MD Omar P. Sangueza MD Yusuke Shiozawa MD PhD Sun Hee Park PhD Christopher M. Peters PhD Edgar Alfonso Romero-Sandoval MD Susan A. Melin MD Steven Sorscher MD Katherine Ansley MD Glenn J. Lesser MD Michael S. Cartwright MD Roy E. Strowd MD 《Muscle & nerve》2020,61(5):587-594
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McAllister Milly J. Kirkwood Kathryn Chuah Shaun C. Thompson Emily J. Cartwright Jennifer A. Russell Clark D. Dorward David A. Lucas Christopher D. Ho Gwo-tzer 《Inflammation》2022,45(2):567-572
Inflammation - The coronavirus SARS-CoV-2 contributes to morbidity and mortality mainly as a result of immune-pathology in the lungs. Recent data has shown multi-system involvement with widespread... 相似文献
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H. P. Roeser G. R. Lee S. Nacht G. E. Cartwright 《The Journal of clinical investigation》1970,49(12):2408-2417
The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation. When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal. When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose. The administration of inorganic copper induced increases in plasma iron only after ceruloplasmin appeared in the circulation. Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma.Studies designed to define the mechanism of action of ceruloplasmin were based on the in vitro observation that ceruloplasmin behaves as an enzyme (ferroxidase) that catalyzes oxidation of ferrous iron. Retention of injected ferrous iron in the plasma of ceruloplasmin-deficient swine was significantly less than that of ferric iron, reflecting impaired transferrin iron binding. Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron. These observations suggest that ceruloplasmin acts by virtue of its ferroxidase activity.Eight patients with Wilson's disease were evaluated in order to investigate iron metabolism in a disorder characterized by reduced ceruloplasmin levels. Evidence of iron deficiency was found in six of these, and in five of the six, plasma ceruloplasmin was less than 5% of normal. In comparison, the two patients without evidence of iron deficiency had ceruloplasmin levels of 11 and 18% of normal. It is suggested that iron deficiency tends to occur in those patients with Wilson's disease who have the severest degrees of hypoceruloplasminemia, possibly because of defective transfer of iron from intestinal mucosal cells to plasma. 相似文献
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Rutkove SB Caress JB Cartwright MS Burns TM Warder J David WS Goyal N Maragakis NJ Clawson L Benatar M Usher S Sharma KR Gautam S Narayanaswami P Raynor EM Watson ML Shefner JM 《Amyotrophic lateral sclerosis》2012,13(5):439-445
Abstract Electrical impedance myography (EIM), a non-invasive, electrophysiological technique, has preliminarily shown value as an ALS biomarker. Here we perform a multicenter study to further assess EIM's potential for tracking ALS. ALS patients were enrolled across eight sites. Each subject underwent EIM, handheld dynamometry (HHD), and the ALS Functional Rating Scale-revised (ALSFRS-R) regularly. Techniques were compared by assessing the coefficient of variation (CoV) in the rate of decline and each technique's correlation to survival. Results showed that in the 60 patients followed for one year, EIM phase measured from the most rapidly progressing muscle in each patient had a CoV in the rate of decline of 0.62, compared to HHD (0.82) and the ALSFRS-R (0.74). Restricting the measurements to the first six months gave a CoV of 0.55 for EIM, 0.93 for HHD, and 0.84 for ALSFRS-R. For both time-periods, all three measures correlated with survival. Based on these data, a six-month clinical trial designed to detect a 20% treatment effect with 80% power using EIM would require only 95 patients/arm compared to the ALSFRS-R, which would require 220 subjects/arm. In conclusion, EIM can serve as a useful ALS biomarker that offers the prospect of greatly accelerating phase 2 clinical trials. 相似文献
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James B. Caress MD Stephanie L. Ciarlone MS Elizabeth A. Sullivan MD Leah P. Griffin MS Michael S. Cartwright MD MS 《Muscle & nerve》2016,53(4):513-517
Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. Results: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month‐to‐month and trended lower after the first year of illness (P = 0.26). Those with limb‐onset and age >60 years had more cramps than bulbar‐onset (P < 0.0001) and younger patients (P < 0.0001). Conclusions: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. Muscle Nerve 53 : 513–517, 2016 相似文献