全文获取类型
收费全文 | 658篇 |
免费 | 21篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 7篇 |
基础医学 | 49篇 |
口腔科学 | 19篇 |
临床医学 | 29篇 |
内科学 | 243篇 |
皮肤病学 | 9篇 |
神经病学 | 28篇 |
特种医学 | 12篇 |
外科学 | 137篇 |
综合类 | 3篇 |
预防医学 | 3篇 |
药学 | 35篇 |
中国医学 | 1篇 |
肿瘤学 | 104篇 |
出版年
2023年 | 7篇 |
2022年 | 2篇 |
2021年 | 19篇 |
2020年 | 12篇 |
2019年 | 10篇 |
2018年 | 24篇 |
2017年 | 14篇 |
2016年 | 14篇 |
2015年 | 24篇 |
2014年 | 7篇 |
2013年 | 30篇 |
2012年 | 38篇 |
2011年 | 45篇 |
2010年 | 27篇 |
2009年 | 15篇 |
2008年 | 27篇 |
2007年 | 44篇 |
2006年 | 49篇 |
2005年 | 34篇 |
2004年 | 24篇 |
2003年 | 31篇 |
2002年 | 24篇 |
2001年 | 10篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1998年 | 5篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 13篇 |
1990年 | 15篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1982年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有688条查询结果,搜索用时 15 毫秒
1.
Yasutoshi Komatsubara Yorihisa Orita Takuma Makino Kazunori Kuroda Yuto Naoi 《Acta oto-laryngologica》2020,140(9):773-778
AbstractBackground: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p?=?.026) and laryngeal dysfunction free rate (p?=?.026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment. 相似文献
2.
Atsushi Nakayama Motohiko Kato Yusaku Takatori Masayuki Shimoda Mari Mizutani Koshiro Tsutsumi Yoshiyuki Kiguchi Teppei Akimoto Motoki Sasaki Makoto Mutaguchi Kaoru Takabayashi Tadateru Maehata Yasutoshi Ochiai Takanori Kanai Naohisa Yahagi 《Digestive endoscopy》2020,32(3):417-424
There are no reports on detailed endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors (SNADET) except for relatively small case series. Herein, we conducted a prospective observational study to investigate the relationship between endoscopic findings and histopathological diagnosis of SNADET. A total of 163 SNADET diagnosed using magnified endoscopic examination with image-enhanced endoscopy (IEE-ME) were prospectively registered in this study. We investigated location, size, macroscopic type, color, and IEE-ME findings including surface structure (closed- or open-loop) and presence of white opaque substance (WOS) in SNADET. We analyzed association between these findings and histopathological diagnosis of SNADET based on the Vienna classification (VCL) using logistic regression analysis. In univariate analysis, lesion size, superficial structure, and WOS deposition showed statistical significance, and the oral side of the lesion location showed statistical tendency for association with VCL C4/5. In multivariate analysis, lesion size (odds ratio [OR], 2.92; 95% CI, 1.94–4.39; P < 0.05) and negative WOS (OR, 5.59; 95% CI, 1.72–18.1; P < 0.05) were significantly associated with VCL C4/5 lesions. Superficial structures with a closed-loop pattern on the surface showed statistical tendency for predicting VCL C4/5 lesions (OR, 2.15; 95% CI, 0.86–5.37; P = 0.10). Based on these findings, we concluded that negative WOS by IEE-ME and lesion size were independent predictors of VCL C4/5 SNADET. These factors may help us to understand of pathophysiology of SNADET and to select appropriate therapeutic strategies. 相似文献
3.
Eikan Mishima Shinji Fukuda Hisato Shima Akiyoshi Hirayama Yasutoshi Akiyama Yoichi Takeuchi Noriko N. Fukuda Takehiro Suzuki Chitose Suzuki Akinori Yuri Koichi Kikuchi Yoshihisa Tomioka Sadayoshi Ito Tomoyoshi Soga Takaaki Abe 《Journal of the American Society of Nephrology : JASN》2015,26(8):1787-1794
The accumulation of uremic toxins is involved in the progression of CKD. Various uremic toxins are derived from gut microbiota, and an imbalance of gut microbiota or dysbiosis is related to renal failure. However, the pathophysiologic mechanisms underlying the relationship between the gut microbiota and renal failure are still obscure. Using an adenine-induced renal failure mouse model, we evaluated the effects of the ClC-2 chloride channel activator lubiprostone (commonly used for the treatment of constipation) on CKD. Oral administration of lubiprostone (500 µg/kg per day) changed the fecal and intestinal properties in mice with renal failure. Additionally, lubiprostone treatment reduced the elevated BUN and protected against tubulointerstitial damage, renal fibrosis, and inflammation. Gut microbiome analysis of 16S rRNA genes in the renal failure mice showed that lubiprostone treatment altered their microbial composition, especially the recovery of the levels of the Lactobacillaceae family and Prevotella genus, which were significantly reduced in the renal failure mice. Furthermore, capillary electrophoresis–mass spectrometry-based metabolome analysis showed that lubiprostone treatment decreased the plasma level of uremic toxins, such as indoxyl sulfate and hippurate, which are derived from gut microbiota, and a more recently discovered uremic toxin, trans-aconitate. These results suggest that lubiprostone ameliorates the progression of CKD and the accumulation of uremic toxins by improving the gut microbiota and intestinal environment. 相似文献
4.
Shigeta T Umeda M Komatsubara H Komori T 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2008,105(4):486-490
We attempted to establish an in vivo experimental model of metastasis of oral caner. The HSC-3 cell line, originating from human oral squamous cell carcinoma, was transplanted into nude mice, and metastases to the lymph node and the lung were investigated using genetic analysis. The HSC-3 cells, transplanted subcutaneously into the lateral back of nude mice, and punctured repeatedly after cyst formation, could metastasize to the lymph node and the lung. Genetic analysis using human beta-globin gene demonstrated that the frequency of metastasis to the lymph node and the lung at 12 weeks after the transplantation was 45% and 40%, respectively. Mutant allele-specific amplification of p53 gene could also detect micrometastasis with almost equal sensitivity of polymerase chain reaction with beta-globin gene. Subcutaneous transplantation is easy with excellent reproducibility compared with intravenous or orthotopic transplantation, and we think that this experimental model can be one of standard models of cancer metastasis. 相似文献
5.
Ishida R Ohkubo M Sugiyama T Honda Y Hosoya M Hattori M Kawata T 《The Bulletin of Tokyo Dental College》2011,52(3):143-147
Feeding development in infants is important not only for of the purpose of acquiring nutrition but also for developing the ability to intake liquids. Our previous study showed that the introduction of a straw was appropriate after an infant has acquired the ability to sip liquid from a spoon and/or cup. In this study, we investigated the effect of a bowlshaped spoon on liquid intake. The aim of this study was to determine the appropriate form of spoon for infant feeding development. Eleven healthy infants (3 girls and 8 boys, 10-18 months old, mean age: 13.3 months) were recruited with their guardians' consent. We made 3 types of prototype spoon: A, oval (a standard renge soup spoon); B, flared-out (with the margin of the bowl flared out); and C, hemispherical (with a hemispherical bottom, and smaller than type A or B). We observed infants taking liquid supported by their mothers and evaluated the following responses: 1) confusion with regard to lip position, 2) spillage and 3) choking. Type C showed statistically less confusion with regard to lip position than type A or B (p<0.01), and B showed less than type A (p<0.05). No statistically significant differences were observed in spillage or choking among the three types of spoon. The renge soup spoon is often used to smooth the transition from breast/bottle to cup feeding. In this study, we demonstrated the appropriate spoon form for infant feeding development. 相似文献
6.
7.
Umeda M Minamikawa T Komatsubara H Ojima Y Shibuya Y Yokoo S Komori T 《The British journal of oral & maxillofacial surgery》2005,43(1):17-22
We retrospectively studied 72 patients with maxillary carcinoma (48 of the gingiva, 22 of the antrum, and one each of the hard palate and maxillary bone). The 5-year survival was 73% for those with gingival carcinoma, and 45% for those with antral carcinoma. Nine patients died of local recurrence, three of cervical metastases, six of distant metastases, and five died of metastases in lateral retropharyngeal nodes despite successful control of local and regional disease. We have recently done en bloc resections of the maxilla and cervical lymph nodes through the parapharyngeal space for patients with posteriorly invasive maxillary cancer accompanied by lymph node metastases in the upper jugular region. 相似文献
8.
Makoto Nishio Atsushi Horiike Hiroshi Nokihara Hidehito Horinouchi Shinji Nakamichi Hiroshi Wakui Fumiyoshi Ohyanagi Keita Kudo Noriko Yanagitani Shunji Takahashi Yasutoshi Kuboki Noboru Yamamoto Yasuhide Yamada Masaichi Abe Takashi Tahata Tomohide Tamura 《Investigational new drugs》2015,33(3):632-640
9.