正常人和原发性高血压血浆肾素活性与生化影响因素关系的探讨(多因素逐步回归分析)

我们曾就原发性高血压血浆肾素活性(PRA),血管紧张素Ⅱ(ATⅡ)与临床流行病学关系进行探讨。现仍用同一数理统计法——多因素逐步回归分析,研究199例     

原发性高血压血浆肾素活性与临床流行病学的关系

肾素一血管紧张素系统在高血压的发病机理中占有重要地位。为寻找原发性高血压的发病因素,提高防治工作,我们对高血压防治普查中符合原发性高血压的患者276例作了进一步的临床观察和流行病学调查,     

电针干预脑缺血损伤作用的实验研究概况

电针对于缺血性脑损伤有治疗作用,目前对其干预作用的实验室研究较为广泛,涉及到组织形态学、分子生物学、电生理学、生化等方面,具体的作用概括为恢复血液供应、神经保护、神经再生三个方面,包括血管新生、抗细胞凋亡、神经干细胞的增殖分化等,笔者就近几年的实验研究结果做一总结。     

原发性高血压肾素、血管紧张素Ⅱ分型及其相互关系的探讨

为了进一步探讨血浆肾素活性(PRA)和血管紧张素Ⅱ(ATⅡ)浓度之间及其与血、尿中钠、钾的关系,并探讨原发性高血压肾素分型变化规律,我们对已进行调查研     

针刺干预脑缺血的电生理研究进展

卒中已成为国内居民首位死亡原因,也是成年人致残的首要原因,而缺血性脑卒中占所有脑卒中类型的80％.针灸在治疗缺血性脑血管病已通过大量的临床与实验研究,并被证实是行之有效的治疗方法,但针剌治疗脑卒中的作用机制尚不完全清楚.而对于针刺治疗脑缺血的电生理机制越来越受到重视.笔者就近20年来针刺干预脑缺血的电生理研究作以综述.     

Effects of different frequencies of electro-acupuncture at Shuigou(GV 26) on recovery of motor function in rats with focal cerebra ischemic injury

OBJECTIVE:To investigate the effects of different frequencies of electro-acupuncture at Shuigou(GV 26) on the latent period and wave amplitude of motor evoked potentials(MEPs) in rats with focal cerebral infarction.METHODS:Fifty healthy male Wistar rats were randomly divided into five groups:controls,model,2 Hz Shuigou,50 Hz Shuigou and 100 Hz Shuigou.There were 10 rats in each group.Using a modification of a technique for middle cerebral artery occlusion,focal cerebral ischemic injury was induced in all rats except those in the control group.The rats in the control group received no treatment.After behavioral deficit had been evaluated using the Zausinger 6-point neurological function score,therats in the Shuigou groups underwent acupuncture and continuous wave stimulation at a frequency of 2 Hz,50 Hz or 100 Hz(intensity 1 mA) for 10 min twice daily for 3 days.The control and model groups underwent no intervention.Zausinger 6-point neurological function score and MEPs were measured 72 h after the start of treatment.RESULTS:The neurological function scores of the three Shuigou groups were significantly higher than those of the model group(P<0.05).There was no significant difference between sides in the latency and amplitude of MEPs in the model group(P> 0.05).The latency on the affected side in the model group was significantly longer than that in the control group(P<0.05) and the amplitude on affected side was significantly reduced(P<0.01).After 3 days of electro-acupuncture,the latency on the affected side in the 2 Hz Shuigou group was significantly shortened(P<0.05) and the amplitude was significantly increased(P<0.05) compared with the model group.CONCLUSION:Low frequency electro-acupuncture at Shuigou(GV 26) can promote recovery of motor function after focal cerebral ischemic injury in rats.     

吲满酰胺的降压作用及对血浆肾素、血管紧张素Ⅱ等含量的影响

吲满酰胺(Indapamide)化学名称4-氯-N-3-磺酰氨基一苯甲酰胺,是一种降压作用较强,利尿作用弱的新降压药。我院自1983年6月对该药进行了临床疗效及对血浆肾素活性(PRA)和血管紧张素Ⅱ(AT_Ⅱ)等含量的影响的观察,报告如下。     

钾通道与缺血性脑损伤的研究进展

钾通道是目前种类最多、作用最复杂的一类离子通道。在调控细胞动作电位的形成、膜复极化、静息电位水平以及细胞分泌等一系列生理活动方面起着重要的作用。钾通道的功能状态与脑缺血关系密切。有研究表明,大脑皮质低氧后几分钟,细胞外K＋浓度就增加了几倍,提示钾通道通透性的异常和稳态的失衡发生在缺血的早期阶段[1]。已有大量研     

电针人中穴改善大脑中动脉闭塞模型大鼠神经功能评分的最优参数筛选研究

以神经功能评分为指标,利用正交实验设计筛选电针人中穴干预大脑中动脉闭塞模型(MCAO)大鼠的最佳参数组合。参照Zea Longa线栓法加以改进制作大脑中动脉闭塞模型,按正交设计分九组不同的电针参数组合干预,以Zausinger六分法评分作为神经功能评价效应指标。电针人中穴的电流因素是改善MCAO大鼠神经功能缺损评分显著因素(P<0.05),刺激频率和刺激电流最优搭配是2 Hz、3 mA。电针人中(2 Hz,3 mA)组与模型组治疗后神经功能评分比较有显著意义(P<0.01)。电针人中穴的电流因素是改善MCAO大鼠神经功能缺损评分的重要因素,且刺激频率和刺激电流存在最优搭配方案。此方案可以明显改善神经功能评分。