峨眉千里光A碱与改进的Ehrlich试剂颜色反应机的探讨

对峨眉千里光Ａ碱在显色反应时过程中与过氧化氢、醋酐、Ｅｈｒｌｉｃｈ试剂等的化学反应机理进行了探讨。这有利于双稠吡咯啶类生物碱及吡咯衍生物等的显色和定量测定．     

N－乙基－N－亚硝基脲诱发大鼠胶质瘤的实验研究

采用人工合成的Ｎ－乙基－Ｎ－亚硝基脲（ＥＮＵ，６０ｍｇ／ｋｇ体重），经胎盘和皮下给药分别在妊娠晚期孕鼠子代和３天龄Ｗｉｓｔａｒ大鼠经１２个月诱发出神经系统胶质瘤．成瘤率分别为７３．２％和６８．３％（胶质瘤为６５．９％和６３．４％）；胶质瘤以少突－星形细胞瘤和少突胶质细胞瘤为主，呈小灶性、多灶性、混合性，并伴有灶性和／或弥漫性胶质增生存在．结果表明，这两种胶质瘤模型为深入研究胶质瘤的发生、生长及分化提供了良好的途径．本文讨论了灶性胶质母细胞增生在胶质瘤发生学上的意义．     

N—乙基—N—亚硝基脲的合成和动物实验

Ethylnitrosourea (ENU) was synthesized with raw materials such as ethylamine and sodium nitrite. The product was a yellowish powder. Its melting point, solubility and infrared absorption spectrum coincided with those reported in the literature. The result form elementary analysis for the product was almost the same as the theoretical value. The product was applied to rats by various methods. It was found that ENU was a cancerogenic compound, especially to the nervous system. More details about the animal experiments will be published in some other papers.     

金属卟啉稳定性与其电子光谱关系的初探

相同卟啉配体与不同金属离子形成的配合物的稳定性取决于金属离子的性质。根据金属离子的结构及金属与卟啉的配位模式等关系对其电子光谱图的不同，作者提出了判断金属卟啉稳定性的依据，即测定该配合物的电子光谱显示的Ｓｏｒｅｔ谱带。实验测得各个金属卟啉的Ｓｏｒｅｔ带红移顺序与稳定系数大小基本一致。     

N-乙基-N-亚硝基脲的合成和动物实验

作者在国内首次合成了N-乙基-N-亚硝基脲,对其熔点、溶解度、红外光谱和元素进行了测定和分析,动物实验表明其对大鼠神经系统有高度的致癌性。     

锌叶绿酸a的合成及初步临床应用

作者以蚕沙提取制得脱镁叶绿酸a,加锌盐合成锌叶绿酸a配合物,这在国内外尚属首创。小鼠急性毒性试验结果表明,本品毒性小,LD_(50)为324±40mg/kg。初步临床试用结果表明,本品有较好的生物活性,能消炎防痛、促进肉芽组织生成和上皮组织修复,对切口感染、口腔粘膜溃疡和浅度烧伤有明显疗效,值得深入研究。     

锌原卟啉的制备

目的 制备锌原卟啉。方法 用猪血或牛血中的血红蛋白制得氯化血红素、原卟啉，再由原卟啉制得锌原卟啉。结果 所制得的锌原卟啉为紫黑色固体，不溶于水，微溶于乙醚，溶于乙醇呈深红色溶液。结论 锌原卟啉在常温下性质稳定，毒性小，与锌叶绿酸a在医疗上有相似的疗效，可进一步做临床实验。     

An experimental study on N-ethyl-N-nitrosourea-induced rat brain gliomas

ＡｎｅｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｙｏｎＮ－ｅｔｈｙｌ－Ｎ－ｎｉｔｒｏｓｏｕｒｅａ－ｉｎｄｕｃｅｄｒａｔｂｒａｉｎｇｌｉｏｍａｓＢｉａｎＸｉｕｗｕ（卞修武）；ＳｈｉＪｉｎｇｑｕａｎ（史景泉）；ＴａｏＨａｉｐｅｎｇ（陶海鹏）；ＹａｎｇＧｕａｎｇｈｕａ...     

锌叶绿酸a的合成及初步临床应用

A method for synthesis of zinc chlorophyllin a (I), a promising drug for clinical application, is presented. Taking silkworm faeces as a raw material. Chlorophyll was extracted with ethyl alcohol. After concentration the solid formed was dissolved in petroleum ether and the solution was subjected to column chromatography to separate pheophytin a and chlorophyll a. The products were dissolved in ethyl ether and the Mg in the products was stripped off with concentrated hydrochloric acid. The excess hydrochloric acid in the solution was neutralized with ammonia solution and the mixture was hydrolyzed with diluted hydrochloric acid to obtain pheophorbide a, then (I) was synthesized with pheophorbide a and zinc salt. The characteristics of (I) and pheophorbide a were checked by IR, UV and elemental analyses. All results of pheophorbide a coincided with those values reported in literature. The acute toxicity of (I) was tested in mice and the LD50 of (I) was 324 +/- 40 mg/kg. (I) has been applied in several hospitals for several months. It has been found that (I) has outstanding effects on burns and oral sepsis and that it increases the growth of granulation tissue and epithelium remarkably.     

铬叶绿酸钠的合成及临床试用初探

采用脱镁叶绿酸与铬络合后制成铬叶绿酸钠口服降糖药,并对１１例糖尿病患者在使用降糖药同时加用铬叶绿酸钠口服进行初步临床验证,观察患者血糖、血胆固醇（ＴＣ）、血甘油三酯（ＴＧ）水平的变化。结果证明铬叶绿酸钠降低血糖、血脂有一定作用。