miR-206与心血管疾病研究进展

微小RNA(microRNA,miRNA)是一大类短链非编码RNA,可以直接结合靶基因的3′非翻译区,进而影响基因表达,在心血管疾病中发挥关键作用。其中,microRNA-206(miR-206)是心脏发育和生理活动的关键调控因子,不仅可以作为诊断的标志分子,也可作为疾病治疗的定向作用点。本文综述了miR-206调节心肌细胞、内皮细胞、平滑肌细胞、自主神经细胞等细胞的基本功能,以及miR-206在冠状动脉疾病、心肌梗死、心力衰竭、心律失常、肺动脉高压等疾病发生发展中的具体作用和机制。     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

主动脉弓综合征的眼部表现

主动脉弓综合征所致眼部异常比较少见 ,我院遇见 1例 ,报告如下。患者男　男　 6 7岁　右眼视物不清 3～ 4个月 ,加重半个月。 3个月前 ,在外地诊为右眼 :陈旧性颞上枝静脉阻塞。右眼视力 0 .12 ,J7;左眼 0 .7,J3,均不能矫正。左眼外眼正常 ,右眼球结膜混合充血 ,角膜透明 ,前房有细胞浮游 ,虹膜 3～ 9点钟处有多量新生血管。瞳孔略开大 ,对光反应稍迟钝。双眼晶体前皮质周边部呈楔形混浊 ,眼压 ;右 40 mm Hg,左 15 mm Hg。左眼除视网膜动脉硬化外 ,余均正常。右眼视乳头边界清晰 ,各象限散在分布点片状出血 ,黄斑区上方有几片棉絮班 (加…     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

山东滕州市农村小学生弱视斜视及立体视锐度调查

Objective To investigate the visual acuity, stereoacuity and the prevalence of amblyopia and strabismus ofprimazy school children in rural areas in Tengzhou, Shandong as well as to evaluate the effi-ciency of three methods in screening amblyopia. Methods In this population-based study, children aged 5 to 14 years old in primary school were randomly selected by a cluster sampling in which school shift was the sam- piing unit. Titmus stereo-test, visual acuity (VA), cover-test and ocular motility evaluation were examined for each child. Retinoscopy was performed for children with VA < 1.0 in either eye. Results ( 1 ) Of 2668 effec-tive examinatious,369 eases (13.83%) were poor eyesight. (2) The prevalence ofamblyopia and strabismus were 1.50% and 1.72% respectively. Out of 40 amblyopia children, 39 were screened at the first time. (3) The stereoacuity in normal children was 40″, 31 (77.5%) children with amblyopia showed abnormal stereoacuity,while 28.3% for strabismus. (4) Specificity and crude agreement of combined Titmus with VA were 99.47%and 99.06% ,which were highest in the three methods. The second was Titmus stereo-test with 97.98% and 97.59%, VA was the lowest. Conelusion The most important cause of poor eyesight in primary school chil-dren is myopia. Amblyopia and strabismus might have significantly effects on stereoacuity. The most efficient method of screening amblyopia was stereo-test combined with visual acuity.     

亚硝酸钠引起集体食物中毒的急救护理

1临床资料 　　1.1一般资料 2005年5月18日下午5时半,我县某餐馆126人同时进餐,81人发生中毒,其中男11例,女70例.年龄3～54岁.中毒潜伏期：最短10min,最长1小时.