抗孕唑啉对啮齿类动物终止妊娠药效学研究

目的:研究抗孕唑啉(L14105)的终止妊娠作用及其作用靶部位。方法:用多种啮齿类动物观察终止早孕及中孕作用;用组织学和细胞培养法观察对细胞的损伤;放射配基分析对子宫胞浆孕酮受体的结合力。结果:L14105对小鼠、大鼠、金黄地鼠与豚鼠均有较强的抗早孕作用,并可致豚鼠中孕堕胎;对体外培养人蜕膜细胞具杀伤力,早孕大鼠用药后24～48h蜕膜细胞开始损伤、胚胎吸收;对大鼠子宫胞浆孕酮受体结合力微弱。结论:L14105对多种啮齿类动物具有很强的终止早孕与中孕活性,其作用靶部位可能为蜕膜细胞。     

Effect of Contragestazolin （ L 1 4 1 0 5 ） on Pregnancy Termination in Rodents

Contragestazolin (L14105) belongs to the class of 2-phenyl-triazote [5, I-a] isoquinolines. When given subcutaneously, intramuscularly or orally showed potential pregnancy-terminating activity in mice, rats, hamsters and guinea pigs, but the dialy doses of oral administration needed were Z 1, 6. 3 and 47, 6 times (for mouse, rat and hamster) greater than those needed parenterally. L14105 had low affinity to rat uterine progesterone receptor. When cultured human deciduat cells were exposed to L14105 0. 077～0. 155 mmol/L for 24～48 h, the cells‘‘ viability markedly dropped and structural changes occurred in comparison with controls, Histological examination of conceptuses of rats showed edema, degeneration, necrosis and atrophy or disappearance of decidual cells nuclei and absorption of embryos after the sc administration of L14105 5mg/kg for 24～48 h. L14105 stimulated the contractile force of uterine smooth muscle in vivo or in vitro. Conclusion： L14105 shows a very high pregnancy terminating activity. Multiple orat administration is also effective. The mode of action of contragestation is related to damage of decidual cells and stimulation of uterine contractility.     

2009—2011年广东省中医院珠海医院抗菌药物应用分析

目的:了解2009—2011年广东省中医院珠海医院(以下简称"我院")抗菌药物的使用情况,为提高抗菌药物合理应用水平提供参考。方法:对2009—2011年我院抗菌药物销售金额、用药频率(DDDs)、限定日费用(DDC)、排序比(B/A)等进行统计分析。结果:2009—2011年我院抗菌药物的销售金额呈下降趋势,且其占药品销售总金额的比例也逐年下降;头孢菌素类抗菌药物的销售金额及其DDDs一直居排序前列。结论:我院抗菌药物使用的品种分布及大多数抗菌药物的使用较合理,但部分药物的DDC偏高、B/A偏低,需进一步加强抗菌药物的合理应用,优化抗菌药物的品种结构,有效减少患者的经济负担。     

重建钢板治疗跟骨骨折46例报告

跟骨骨折临床常见，约占足部骨折的60％。过去多采用非手术治疗，常遗留疼痛、扁平足、创伤性关节炎等后遗症，对承重、行走影响极大。自2001年5月至2004年11月，作者采用重建钢板治疗跟骨骨折46例，取得了满意疗效，现总结报告如下。