全文获取类型
收费全文 | 1755187篇 |
免费 | 132201篇 |
国内免费 | 6547篇 |
专业分类
耳鼻咽喉 | 22748篇 |
儿科学 | 56447篇 |
妇产科学 | 47723篇 |
基础医学 | 249876篇 |
口腔科学 | 50302篇 |
临床医学 | 157412篇 |
内科学 | 343795篇 |
皮肤病学 | 40029篇 |
神经病学 | 135030篇 |
特种医学 | 66102篇 |
外国民族医学 | 265篇 |
外科学 | 265130篇 |
综合类 | 45729篇 |
现状与发展 | 9篇 |
一般理论 | 542篇 |
预防医学 | 127781篇 |
眼科学 | 41815篇 |
药学 | 130090篇 |
29篇 | |
中国医学 | 6603篇 |
肿瘤学 | 106478篇 |
出版年
2021年 | 14084篇 |
2019年 | 15035篇 |
2018年 | 21915篇 |
2017年 | 16831篇 |
2016年 | 18186篇 |
2015年 | 21057篇 |
2014年 | 28870篇 |
2013年 | 40829篇 |
2012年 | 56719篇 |
2011年 | 59541篇 |
2010年 | 35343篇 |
2009年 | 32862篇 |
2008年 | 54556篇 |
2007年 | 57903篇 |
2006年 | 58251篇 |
2005年 | 55342篇 |
2004年 | 52913篇 |
2003年 | 50301篇 |
2002年 | 48267篇 |
2001年 | 95499篇 |
2000年 | 97281篇 |
1999年 | 80205篇 |
1998年 | 21182篇 |
1997年 | 18317篇 |
1996年 | 17123篇 |
1995年 | 17273篇 |
1994年 | 15809篇 |
1993年 | 14493篇 |
1992年 | 58959篇 |
1991年 | 56672篇 |
1990年 | 54255篇 |
1989年 | 51944篇 |
1988年 | 47201篇 |
1987年 | 45888篇 |
1986年 | 43052篇 |
1985年 | 40740篇 |
1984年 | 29818篇 |
1983年 | 25224篇 |
1982年 | 14039篇 |
1979年 | 25710篇 |
1978年 | 17608篇 |
1977年 | 14917篇 |
1976年 | 13899篇 |
1975年 | 14584篇 |
1974年 | 17674篇 |
1973年 | 17010篇 |
1972年 | 15735篇 |
1971年 | 14496篇 |
1970年 | 13484篇 |
1969年 | 12562篇 |
排序方式: 共有10000条查询结果,搜索用时 734 毫秒
1.
Molnár B. Aroca S. Dobos A. Orbán K. Szabó J. Windisch P. Stähli A. Sculean A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with... 相似文献
2.
目的收集特重度烧伤(总TBSA50%以上或三度TBSA20%以上或伴有严重并发症者)患者围术期凝血指标(APTT、PT、FIB、DD和PLT),分析静吸复合麻醉对患者凝血功能的影响及其临床意义。
方法选取近3年内蒙古医科大学第三附属医院烧伤外科收治的特重度烧伤患者148例,根据入院14 d内的预后分为死亡组和生存组,生存组男性129例,女性9例;年龄24~59岁,平均(43.30±12.90)岁。死亡组男性8例,女性2例;年龄26~63岁,平均(46.19±15.41)岁。收集入院时(T0),术前(早晨入手术室前,T1),术毕(送至PACU未拔除气管导管前,T2)及术后2 d(T3)4个时间点的凝血指标,比较两组凝血指标动态差异。
结果死亡组休克期输液量、累计血浆、红细胞输入量显著高于生存组(P<0.01)。T0时,生存组的FIB(1.78±0.32)显著高于死亡组(1.26±0.07)(P<0.05);T2时,两组APTT、PT均显著缩短(P<0.05),生存组的FIB(3.86±0.40)显著高于死亡组(2.45±1.02)(P<0.05);T3时,死亡组PLT显著低于生存组(P<0.01)。
结论特重度烧伤患者在围手术期易出现高凝状态,并且这可能导致患者死亡。静吸复合麻醉和围术期大量液体复苏会促进患者的高凝状态。 相似文献
3.
Kienbaum Peter Schaefer Maximilian S. Weibel Stephanie Schlesinger Tobias Meybohm Patrick Eberhart Leopold H. Kranke Peter 《Der Anaesthesist》2022,71(2):123-128
Die Anaesthesiologie - Auch wenn für Anästhesiologen über Jahrzehnte die Prophylaxe und Therapie postoperativer Schmerzen im Rahmen des postoperativen Patientenkomforts an vorderster... 相似文献
4.
5.
6.
7.
8.
Karl Johnson Katherine W. Saylor Isabella Guynn Karen Hicklin Jonathan S. Berg Kristen Hassmiller Lich 《Genetics in medicine》2022,24(2):262-288
PurposeUnderstanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.MethodsWe searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.ResultsAcross the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared between 2 and >20 alternative interventions. Many studies failed to report sufficient detail to enable replication or did not justify modeling assumptions, especially for costing methods and utility values. Meta-analyses, systematic reviews, or calibration were rarely used to derive parameter estimates. Nearly all studies conducted some sensitivity analysis, and more sophisticated studies implemented probabilistic sensitivity/uncertainty analysis, threshold analysis, and value of information analysis.ConclusionWe describe a heterogeneous body of work and present recommendations and exemplar studies across the methodological domains of (1) perspective, scope, and parameter selection; (2) use of uncertainty/sensitivity analyses; and (3) reporting transparency for improvement in the economic evaluation of genetic screening/testing. 相似文献
9.
Ludefu Su Yu Liu Yanhong Tang Mingmin Zhou Liang Xiong Congxin Huang 《International journal of clinical and experimental pathology》2021,14(4):408
Background and objective: Myocardial infarction (MI) is a common critical disease of the cardiovascular system. The process of MI is often accompanied by the excessive activation of cardiac sympathetic nerves, which leads to arrhythmia. Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. However, whether RTX can reduce the occurrence of arrhythmia and exert a cardioprotective effect by inhibiting the sympathetic reflex during MI is still unknown. Methods: The left anterior descending artery of cardiac was clamped to construct a model of MI. RTX (50 μg/ml) was used by epicardial application in MI rats. Ventricular electrophysiologic properties were continuously monitored by a body surface ECG. Yrosine hydroxylase (TH) and growth associated protein 43 (GAP43) were detected by Immunofluorescence staining. Connexin43 and transforming growth factor beta receptor 1 (TGF-β1) were detected by western blot. Norepinephrine (NE) and BNP levels in blood and tissue were determined by ELISA. Cardiac function was assessed by echocardiography. Results: The ERP, APD90, QRS, QT and the Tend-Tpeak intervals in MI rats were all prolonged, but decreased after RTX treatment (n = 3, P<0.05). In contrast, the RR interval was shortened in the MI group, but prolonged in the MI+RTX group (n = 3, P<0.05). RTX treatment significantly reduced ventricular arrhythmias after MI. TH- and GAP43-positive nerve densities and TGF-β1, and cx-43 protein expression were up-regulated in the MI group compared to the sham group, and they were decreased in the MI+RTX group compared to the MI group (n = 3, P<0.05). RTX can decrease serum and tissue NE and BNP levels (n = 3, P<0.05). RTX pretreatment significantly decreased heart rate, HW/BW ratio and LVIDS, and increased LVEF andLVFS values (n = 3, P<0.05). Conclusion: RTX improved cardiac dysfunction, ventricular electrophysiologic properties, and sympathetic nerve remodeling in rats with MI by inhibiting the excessive cardiac sympathetic drive. 相似文献
10.